Navigation Links
Experts advocate realigning type 2 diabetes treatments with disease's natural history
Date:10/6/2010

Chevy Chase, MD A new consensus statement published in the September, 2010, issue of The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) finds that the increasing recognition that beta-cell failure occurs much earlier and severely than commonly believed suggests that regular glycemia screening, early identification of patients at metabolic risk and prompt and aggressive intervention deserves greater emphasis.

The consensus statement is based on the findings of a working group of basic researchers, clinical endocrinologists and primary care physicians convened by The Endocrine Society, to consider whether current knowledge regarding pancreatic beta-cell defects justifies retargeting and retiming treatment for diabetes in clinical practice.

"There is widespread evidence that conventional approaches to the management of type 2 diabetes have been inadequate," said Jack L. Leahy, MD, of the Vermont Regional Diabetes Center in South Burlington, and one of the authors of the consensus statement. "Studies have increasingly shown that beta-cells have an important role in the progression of diabetes and if we could gain a better understanding of that role, we may be able to develop new and effective means of treatment. To that end, working group members advocate for continued basic research to elucidate the nature and mechanisms of beta-cell failure in type 2 diabetes."

Evidence from both human and animal studies suggests that type 2 diabetes is characterized by dysfunctional beta-cells that cannot adapt insulin secretion to compensate for increasing insulin resistance. Beta-cell failure is believed to occur at an early stage in the progression of diabetes, and accumulating evidence suggests that the decline in beta-cell function may be slowed or even reversed, particularly if addressed early.

"Another recommendation of the working group is to explore new educational approaches to promote pathophysiology-based clinical practices, and that is why the Society has launched the new Web site, BetaCellsinDiabetes.org," said Leahy. "It is our hope that the new site will aid primary care physicians in the interpretation of concepts of disease pathogenesis, such as beta-cell dysfunction, and improve medical decision-making regarding treatment of type 2 diabetes. We have made the site practical by synthesizing research, creating case studies, providing a curated list of the published literature, and inviting viewers to comment throughout the site."

In the consensus statement, experts also recommend additional studies to establish the clinical value of pharmacological therapies targeting beta-cell function. In addition, further research should aim to determine whether specific genetic subtypes of type 2 diabetes lend themselves to individualized therapy to slow or reverse beta-cell decline.

"More research is needed to determine whether preserving beta-cell function improves morbidity and mortality rates," said Leahy. "Nonetheless, the increasing recognition that beta-cell failure occurs much earlier and severely than commonly believed suggests that regular glycemia screening, early identification of patients at metabolic risk and prompt and aggressive intervention deserves greater emphasis."

The 2009 working group meeting was funded by an unrestricted educational grant from Novo Nordisk. The consensus statement, "Targeting β-Cell Function Early in the Course of Therapy for Type 2 Diabetes Mellitus," appears in the September 2010 issue of JCEM.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Experts urge making cigarettes non-addictive a research priority
2. Decline in Adult Smoking Stalls, Alarming Experts
3. Experts recommend universal screening of newborns for congenital adrenal hyperplasia
4. Nations leading ID experts call for mandatory flu vaccine for all health-care personnel
5. Eggs Being Produced by Recall Farms Safe, if Pasteurized, Experts Say
6. Experts Predict Normal H1N1 Flu Season This Year
7. Experts Support FDA Panels Backing of New Blood Thinner
8. Sunscreen Concerns Unfounded, Experts Say
9. Experts Issue New Guidelines on Breast Cancer Drugs
10. Experts Believe Many Birth Defects Are Preventable
11. Experts Optimistic About Solving Puzzle of Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... August 22, 2017 , ... “Covert Awakening”: Walid’s spiritual ... published author, Julianne Hale, a consultant for the Intelligence Community. For more ... on the Near East region. Julianne has written hundreds of reports for ...
(Date:8/22/2017)... ... August 22, 2017 , ... TopConsumerReviews.com recently gave a best-in-class ... Fatigue . , As the stress of modern life continually makes more demands on ... use of artificial stimulants can trap people in vicious high/low cycles and can also ...
(Date:8/21/2017)... ... August 22, 2017 , ... PracticeMatch, a company that provides online ... with physicians and advanced practitioners like nurse practitioners and physician assistants ... through November of this year. The online career fairs will allow job seekers to ...
(Date:8/21/2017)... ... August 21, 2017 , ... Los Angeles area medical ... for academic year 2017-2018, Christina M. Busuito, M.D. and Lukasz Swistun, M.D. This ... Plastic and Reconstructive Surgery. The candidate will have the opportunity to work ...
(Date:8/21/2017)... ... August 21, 2017 , ... Five chefs from local ... for Alzheimer’s Family Center. , Guests will be able to vote for their ... Braised Lamb Shank with Fennel Dill Salad, Feta Cheese Sauce & Garlic Pita Crisp, ...
Breaking Medicine News(10 mins):
(Date:8/8/2017)... AVIV, Israel, Aug. 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: ... immunology, today reports its financial results for the second ... achievements during the second quarter 2017 and to date: ... multiple clinical development programs for the Company,s lead project, ... 3 pivotal study with BL-8040 as novel stem cell ...
(Date:8/7/2017)... FLINT, Mich., Aug. 7, 2017  Diplomat Pharmacy, Inc. (NYSE: ... for the quarter ended June 30, 2017.  All comparisons, unless ... Second Quarter 2017 ... compared to $1,089 million, an increase of 3.5% ... Gross margin of 7.5% versus 7.6% ...
(Date:8/2/2017)... 2017 Fenita J. Caldwell ... Pinnacle Lifetime Professional in the Field of Healthcare. ... Turing Pharmaceuticals, AG. Her skills and areas of ... ... of experience as a highly successful sales specialist ...
Breaking Medicine Technology: