Navigation Links
Experts Release New Cystic Fibrosis Guidelines

Includes updated info on which drugs work, which don't

THURSDAY, Nov. 15 (HealthDay News) -- Experts on Thursday issued new clinical standards for the treatment of cystic fibrosis (CF).

The guidelines were based on a two-year review of published research on patients aged six and older.

"Physicians treating patients with CF are faced with a growing number of treatment options. We are hopeful that clinicians will find these recommendations to be useful in their care of patients with CF," the guidelines' lead author, Dr. Patrick A. Flume, said in a prepared statement.

CF is a genetic disease that affects the lungs and other organs. It's characterized by thick, sticky mucus that makes it almost impossible for CF patients to fight off germs and infections. The disease is always fatal, and lung disease accounts for 85 percent of deaths among CF patients. However, advances in treatment in the last 60 years have increased life expectancy from just a few years to about 36 years.

Flume and his colleagues looked at a number of treatments and rated their effectiveness. Those with the strongest, most consistent results were given an "A" grade recommendation. They are:

  • Inhaled tobramycin -- an antibiotic -- to suppress chronic Pseudomonas aeruginosa infections in CF patients with moderate to severe disease, to improve lung function and reduce exacerbations.
  • Dornase alfa, which degrades the free DNA that accumulates in CF mucus, thereby loosening the mucus, promoting airway clearance, improving lung function and reducing exacerbations.

"B" grade recommendations were given for:

  • Inhaled tobramycin, to suppress Pseudomonas aeruginosa infections in CF patients with mild disease or who are asymptomatic, to reduce exacerbations.
  • Dornase alfa, for CF patients with mild disease who are asymptomatic, to improve lung function and reduce exacerbations.
  • Hypertonic saline, which hydrates surface liquid in patients with CF, thereby improving lung function and decreasing exacerbations.
  • Beta 2-adrenergic receptor agonists, which relax smooth muscles and dilate bronchial passages, which improve lung function in CF patients, and are well-tolerated.

The guidelines recommend against:

  • Systemic corticosteroids in children because of "an excess number of adverse events," including abnormalities in glucose metabolism, cataracts, and percentage of patients "colonized" with Pseudomonas. This recommendation excludes patients with concomitant asthma.
  • Inhaled corticosteroids, because there's no clinical benefit. This recommendation excludes patients who also have asthma, however.
  • Prophylactic anti-Staphylococcal antibiotics because of the lack of clinical efficacy and an apparent increase in P. aeruginosa infections with their use.

There wasn't sufficient evidence to recommend for or against other types of treatment, said Flume and his colleagues.

The guidelines are published in the second issue for November of the American Journal of Respiratory and Critical Care Medicine.

More information

The March of Dimes has more about cystic fibrosis.

-- Robert Preidt

SOURCE: American Thoracic Society, news release, Nov. 15, 2007

Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
3. Health IT Event Draws Experts to the Pacific Northwest
4. Experts Sort Out Good Fats From Bad
5. Experts Offer Tips on Lung Cancer Prevention
6. March of Dimes, Experts for Moms and Babies, Launches Podcast
7. World fertility experts to meet in Montreal - IVF and IVM patients to provide first-person accounts at 14th World Congress
8. Bay IVF Experts Launch One of First East-West Fertility Programs of Its Kind
9. Experts propose cholesterol tests at 15 months of age
10. Experts Publish New Lung Disease Guidelines
11. Experts, Advocates Available to Comment on Hillary Clintons Health Care Plan
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... In an ongoing Clinical Study ... (RMC) in Chicago, IL, UV Angel is evaluating the efficacy of its product and ... care units (totaling 30 beds) from May 2014 through October 2015 at a 360-bed, ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care ... disease. The Periwinkle Pioneers, nominated by the public, will receive special recognition throughout ...
(Date:11/25/2015)... ... November 25, 2015 , ... Many people know of the common ... cold hands, and dry skin. But many people who find their cholesterol levels and ... instead of their thyroid, especially if they don’t have any of the other symptoms. ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... is offering lower prices in an early celebration of the early holiday shopping ... price of $29.95 each (normally $33.95 ea). Black Friday promotional pricing is in ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... New patients ... without a referral for dental implants at her Mississauga, ON practice. Dr. ... experienced in the placement of dental implants. , Missing teeth can lead to ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , November 25, 2015 Developmental, commercial, ... in boosting the profitability of pharmaceutical products, says ... and regulatory/legal strategies all play a key ... says GBI Research . --> ... a key role in boosting the profitability of pharmaceutical products, ...
(Date:11/24/2015)... 2015 The hope of bearing ... of IVF cycles. After failure of over 15 IVF ... lost all hopes that she would be able to conceive ever. But finally optimism prevailed ... after failure of over 15 IVF cycles. ... to take one last attempt with Gaudium IVF Center in ...
(Date:11/24/2015)... HILL, N.C. , Nov. 24, 2015  In ... research projects in an effort to quickly uncover new ... position. --> --> ... launch a market research project and ensure that all ... company and industry standards. Another major barrier to efficiently ...
Breaking Medicine Technology: