Navigation Links
Experts Release New Cystic Fibrosis Guidelines
Date:11/15/2007

Includes updated info on which drugs work, which don't

THURSDAY, Nov. 15 (HealthDay News) -- Experts on Thursday issued new clinical standards for the treatment of cystic fibrosis (CF).

The guidelines were based on a two-year review of published research on patients aged six and older.

"Physicians treating patients with CF are faced with a growing number of treatment options. We are hopeful that clinicians will find these recommendations to be useful in their care of patients with CF," the guidelines' lead author, Dr. Patrick A. Flume, said in a prepared statement.

CF is a genetic disease that affects the lungs and other organs. It's characterized by thick, sticky mucus that makes it almost impossible for CF patients to fight off germs and infections. The disease is always fatal, and lung disease accounts for 85 percent of deaths among CF patients. However, advances in treatment in the last 60 years have increased life expectancy from just a few years to about 36 years.

Flume and his colleagues looked at a number of treatments and rated their effectiveness. Those with the strongest, most consistent results were given an "A" grade recommendation. They are:

  • Inhaled tobramycin -- an antibiotic -- to suppress chronic Pseudomonas aeruginosa infections in CF patients with moderate to severe disease, to improve lung function and reduce exacerbations.
  • Dornase alfa, which degrades the free DNA that accumulates in CF mucus, thereby loosening the mucus, promoting airway clearance, improving lung function and reducing exacerbations.

"B" grade recommendations were given for:

  • Inhaled tobramycin, to suppress Pseudomonas aeruginosa infections in CF patients with mild disease or who are asymptomatic, to reduce exacerbations.
  • Dornase alfa, for CF patients with mild disease who are asymptomatic, to improve lung function and reduce exacerbations.
  • Hypertonic saline, which hydrates surface liquid in patients with CF, thereby improving lung function and decreasing exacerbations.
  • Beta 2-adrenergic receptor agonists, which relax smooth muscles and dilate bronchial passages, which improve lung function in CF patients, and are well-tolerated.

The guidelines recommend against:

  • Systemic corticosteroids in children because of "an excess number of adverse events," including abnormalities in glucose metabolism, cataracts, and percentage of patients "colonized" with Pseudomonas. This recommendation excludes patients with concomitant asthma.
  • Inhaled corticosteroids, because there's no clinical benefit. This recommendation excludes patients who also have asthma, however.
  • Prophylactic anti-Staphylococcal antibiotics because of the lack of clinical efficacy and an apparent increase in P. aeruginosa infections with their use.

There wasn't sufficient evidence to recommend for or against other types of treatment, said Flume and his colleagues.

The guidelines are published in the second issue for November of the American Journal of Respiratory and Critical Care Medicine.

More information

The March of Dimes has more about cystic fibrosis.



-- Robert Preidt



SOURCE: American Thoracic Society, news release, Nov. 15, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
2. MultiVu Video Feed: PUBLIC HEALTH EXPERTS CONVENE TO DISCUSS THE TREATMENT AND PREVENTION OF RABIES
3. Health IT Event Draws Experts to the Pacific Northwest
4. Experts Sort Out Good Fats From Bad
5. Experts Offer Tips on Lung Cancer Prevention
6. March of Dimes, Experts for Moms and Babies, Launches Podcast
7. World fertility experts to meet in Montreal - IVF and IVM patients to provide first-person accounts at 14th World Congress
8. Bay IVF Experts Launch One of First East-West Fertility Programs of Its Kind
9. Experts propose cholesterol tests at 15 months of age
10. Experts Publish New Lung Disease Guidelines
11. Experts, Advocates Available to Comment on Hillary Clintons Health Care Plan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)... ... ... Earlier this month, the Workgroup for Electronic Data Interchange (WEDI) , ... in healthcare information exchange and a trusted advisor to the U.S. Department of Health ... addresses by Donald W. Rucker, MD, head of the Office of the National Coordinator ...
(Date:8/23/2017)... Houston, TX (PRWEB) , ... August 23, 2017 ... ... specializing in the healthcare industry, made the 2017 Inc. 5000 with a ... ranking of the nation’s fastest-growing private companies and comprises the most comprehensive look ...
(Date:8/23/2017)... ... August 23, 2017 , ... Silicon Valley Hair Institute, a leading San Francisco ... month-by-month. The new rotation of archived blog posts can provide a wide selection of ... hair transplantation can review details online and then reach out for a no obligation ...
(Date:8/22/2017)... ... August 22, 2017 , ... Nuvesse Skin ... and serums that perfectly fuse the beauty of naturally derived ingredients with the ... Beauty Expo on August 23rd & 24th in New York City. , Indie ...
(Date:8/22/2017)... ... 2017 , ... Each of the past six years, Lightning Labels has sent out a call ... stickers, demonstrating the variety and creativity of their designs. Submissions this year were open from ... it's time to announce the winners of the sixth annual Photo Contest, along with the ...
Breaking Medicine News(10 mins):
(Date:8/10/2017)... -- Physical Rehabilitation Network (PRN), acquired the long-standing outpatient rehabilitation clinic, ... . The reputable clinic will continue to be co-owned and ... staff of four clinicians. Lipkin received his doctorate in physical ... years of experience with a strong background in manual therapy. ... 10th PRN clinic in and around the Denver ...
(Date:8/7/2017)... WARSAW, Ind. , Aug. 7, 2017 Zimmer ... in musculoskeletal healthcare, today announced that its Board of Directors ... stockholders for the third quarter of 2017. ... will be paid on or about October 27, 2017 to ... September 22, 2017.  Future declarations of dividends are subject to ...
(Date:8/4/2017)... Md. , Aug. 4, 2017 The ... or shortly after a physician/patient consult has long been ... and was a notable focus of the largest meeting ... is according to healthcare market research firm Kalorama Information. ... care testing (POCT) offerings or related supplies and software ...
Breaking Medicine Technology: