Navigation Links
Experts Debate Tylenol's Safety for Asthmatic Kids
Date:11/7/2011

By Serena Gordon
HealthDay Reporter

MONDAY, Nov. 7 (HealthDay News) -- Taken in the proper dose, acetaminophen has long been considered one of the safest over-the-counter medications. It's approved for use in children, and many obstetricians are even OK with its use during pregnancy.

But an Ohio pediatrician thinks it's time to rein in use of acetaminophen -- more popularly known as Tylenol -- particularly in people with asthma.

"The fundamental issue is that there's an epidemiological problem associated with acetaminophen and asthma," explained Dr. John McBride, vice chair of the department of pediatrics and director of the Robert T. Stone Respiratory Center at Akron Children's Hospital.

"Is that because acetaminophen contributes to asthma, or is it just because people with asthma tend to take acetaminophen?" he said.

Until a large-scale study definitively answers that question, McBride said, "I think we owe it to our patients and their parents to make it clear that maybe acetaminophen is bad. And, if there are alternatives, people might want to use those alternatives until they know acetaminophen is safe."

McBride reviewed the available evidence linking the pain reliever/fever reducer and asthma for an article published in the December issue of Pediatrics.

One source was the International Study of Allergy and Asthma in Childhood, which included more than half a million children at 122 centers in 54 countries. About 200,000 kids were 6 to 7 years old, and 320,000 were between 13 and 14 years old.

Almost one in three of the older children reported taking acetaminophen at least once a month.

In children who took acetaminophen more than once a year, but less than once a month, the researcher found the risk of current asthma was 61 percent higher in the 6 to 7 year olds. For these young children who took acetaminophen more than once a month, the risk of having asthma was more than tripled.

The older children fared slightly better with an increased risk of 43 percent in those who took the drug more than once a year, but less than once a month. For those who took acetaminophen more than once a month, the risk of having asthma increased by 2.5 times, according to the report.

McBride calculated that if acetaminophen exposure was eliminated in that teen group, the rate of severe asthma symptoms would decline by 43 percent.

He also reviewed a meta-analysis of six studies involving almost 90,000 adults in total. Weekly use of acetaminophen was linked to a 1.74 times higher risk of asthma in adults, McBride found.

In addition, the researcher looked at two prospective studies done on acetaminophen and asthma in the early 1990s. These studies, which followed a group of individuals for a period of time, also found a strong link between asthma and acetaminophen.

McBride said the evidence is stronger that acetaminophen exacerbates current asthma, but that there's also evidence that it may be a cause of asthma, too.

How this occurs remains subject to debate, but some researchers believe acetaminophen increases airway inflammation in people with asthma or a predisposition to the breathing disorder, he said.

Dr. Len Horovitz, an internist and pulmonary specialist at Lenox Hill Hospital in New York City, said, "This information suggests that we have to be cautious about acetaminophen in children with asthma or a family history of asthma. The alternative is ibuprofen, which a lot of parents seem to prefer anyway."

"I do think further research is needed," Horovitz added.

He cautioned that a small group of people with asthma are sensitive to aspirin, and said there are some others who have nasal polyps who shouldn't take ibuprofen (Advil, Motrin).

Not everyone is convinced that the association seen in the new study leads to cause and effect.

"Asthma is such a complex disease, and people all over the world are trying to figure out what causes it," said Dr. Jennifer Appleyard, chief of allergy and immunology at St. John Hospital and Medical Center in Detroit. She said that the asthma likely has a number of causes, not just one.

"I don't feel strongly swayed enough to tell my patients they shouldn't take acetaminophen. In anyone with a fever, it's good to minimize the amount of medications and give them just when they're needed." But, she said, an untreated fever can also be dangerous, and parents want to make their children comfortable when they're sick.

But until there's good evidence that acetaminophen is safe, McBride is telling his patients to avoid it.

If his own wife were pregnant, he said he'd suggest that she avoid taking acetaminophen, too. "It's not because I think it's very likely that it's a problem in pregnancy, but in the absence of evidence, why take it?" said McBride.

More information

Learn more about asthma triggers and treatment from the American Academy of Allergy, Asthma and Immunology.

SOURCES: John McBride, M.D., vice chair, department of pediatrics, director, Robert T. Stone Respiratory Center, Akron Children's Hospital, Ohio; Jennifer Appleyard, M.D., chief, allergy and immunology, St. John Hospital and Medical Center, Detroit; Len Horovitz, M.D., internist and pulmonary specialist, Lenox Hill Hospital, New York City; December 2011, Pediatrics


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Local Carrollton Center Hosting More than 50 Autism Experts from Coast-to-Coast
2. Experts call for acceleration of research and interventions for prematurity and stillbirth
3. Verizon Health Care IT Experts to Present at Atlanta Conference on March 2, 3
4. FDA Appoints Highly Qualified Scientific Experts to Tobacco Products Scientific Advisory Committee
5. Experts call for further research into the relationship between insulin therapy and cancer
6. Experts support new federal center for Medicare and Medicaid innovation
7. David Wolfe Hosts 3-Day Longevity Conference: Top Wellness Experts Reveal Tomorrow's Best Natural Health and Nutrition Information Today
8. Alert: Bloomberg to Gather Healthcare Experts in Chicago, April 27th
9. Bipartisan Capitol Hill Media Event: Health Experts, Lawmakers to Urge Federal Government to Fix the Funding Failure for Chronic Viral Hepatitis
10. Two Top Sleep Experts Team Up On New Pillow Collection
11. Experts Say Its Not So Bad to Go a Little Mad
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experts Debate Tylenol's Safety for Asthmatic Kids
(Date:6/27/2016)... Dublin, CA (PRWEB) , ... June 27, 2016 ... ... Community College District , the only authorized OSHA Training Institute Education Center headquartered ... illness by protecting their workers from extreme heat at their worksites. Employers ...
(Date:6/27/2016)... ... , ... "FCPX editors can now reveal their media with growing colorful split ... Austin - CEO of Pixel Film Studios. , ProSlice Color brings the split ... now reveal the media of their split screens with growing colorful panels. , ProSlice ...
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... today its affiliation with Tennessee Counseling Association. This new relationship allows ... the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... industry today announced its strategic partnership with Connance, a healthcare industry leader ... two companies’ proven, proprietary technology combine to provide health systems, hospitals and ...
(Date:6/27/2016)... ... 2016 , ... A revolution is underway. Brooklyn-based company, ... for the millions of people who require these medical transport services annually. ... the use of technology. Now, SmartEMS has put forth an industry-changing app that ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- One of Australia,s successful biotechnology scientists, ... new biotechnology company, Noxopharm Limited [ABN 50 608 966 123] ("Noxopharm"). ... list on the ASX. Noxopharm is a clinic-ready company ... Phase 1 clinical study later this year. ... biggest problems facing cancer patients - the ability of cancers to ...
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... p.m. (Eastern Daylight Time). As previously announced ... into a definitive merger agreement under which Jazz Pharmaceuticals ...
(Date:6/26/2016)... -- VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) reported today ... to build a strong and stable market for trading ... the OTC Markets-pink current trading platform. Explains ... seeing an anomaly in market trading activities that may ... Company, but shareholders and market players as well. I ...
Breaking Medicine Technology: