Navigation Links
Experts Compare Colon Cancer Treatment Outcomes
Date:9/21/2007

Review of studies shows big survival gains

THURSDAY, Sept. 20 (HealthDay News) -- The current chemotherapy regimens of irinotecan, oxaliplatin, and molecular-targeted treatments are helping patients with advanced colorectal cancer live several months longer than they did a few years ago, when these therapies weren't available, Greek researchers say.

Researchers at the University of Ioannina School of Medicine performed a meta-analysis of 242 studies on these chemotherapies, conducted over the past 40 years.

The study was published online Thursday in The Lancet Oncology journal.

Previous studies have noted survival benefits for patients receiving the newer regimens, but the degree of these benefits across assorted regimens has been less clear, the team said.

They conducted the meta-analysis to examine whether certain treatment regimens for advanced colorectal cancer offer better survival and delayed disease progression and to determine the extent of such benefits.

According to the study, among patients who would be expected to live for one year when treated with the drugs fluorouracil and leucovorin, there was an estimated absolute survival benefit of an extra eight months if patients received additional treatment with irinotecan plus bevacizumab.

The researchers also concluded that the addition of oxaliplatin plus bevacizumab or irinotecan plus oxaliplatin offered four to seven additional months of survival for patients.

However, the researchers also noted that multidrug combinations that improve survival can cause serious toxic side effects. They called for long-term follow-up data on toxicity associated with these treatments.

"The fluorouracil, leucovorin, irinotecan, plus bevacizumab regimen especially, which has the highest probability to be the best in improving survival according to our analysis, might be complicated by up to 84.9 percent of grade 3 or 4 adverse events, including a 1.5 percent chance of gastrointestinal perforation," the researchers noted. "(These) existing uncertainties suggest that more data are needed, especially for the newest regimens", they said.

More information

The American Cancer Society has more about colorectal cancer treatment decisions.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, Sept. 20, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Smoking a greater risk than HIV? Yes say health experts!!!!
2. Good carb, bad carb? Experts debate.
3. Serevent, to be examined by experts due to deaths associated with its use
4. Spread Of Rocky Mountain Spotted Fever Is A Probability, Say Experts
5. Experts Recommend Preventive Measures For Avian Flu To Begin From Farms
6. Experts Insist That Neonatal Herpes Be Reported Regularly
7. Experts State Strategies To Increase Good Cholesterol
8. Speed up bird flu vaccine, Bush tells experts
9. Tennis elbow not new among cricketers, say experts
10. Cancer Can Recur Any Time, Experts Caution
11. Experts Building Bird Flu Warning System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Mass. and SAN CLEMENTE, Calif. , ... California -based mobile pulmonary function testing company, is now able ... PFT devices developed by ndd Medical Technologies , Inc. ... testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® ... , can get any needed testing done in the comfort ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
Breaking Medicine Technology: