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Experimental obesity drug avoids brain effects that troubled predecessors
Date:7/12/2010

hese results indicate its development as a potential new treatment should be advanced."

In the rodent studies, the researchers conducted an extensive panel of studies with mice and rats to assess the weight-loss and anti-diabetic potential of the as-yet unnamed drug, TM38837, and to demonstrate the lack of exposure in the brain.

The researchers treated obese rats and mice with rimonabant, the new drug, or a placebo drug once a day for five weeks and measured their body weight and food intake daily. Animals lost an equal amount of body weight when treated with similar doses of rimonabant and TM38837. At the end of the treatment period, drug treated mice had 22-26% lower body weights than placebo treated mice while drug treated rats had 14% lower body weights than placebo treated rats.

Other animal studies provided substantial evidence that the drug has a markedly lower propensity than rimonabant to cross the blood-brain barrier. These studies included brain tissue examination, behavioural tests and other studies to demonstrate where in the body the drug was distributed.

For their human study of the drug, the researchers reported that in a phase 1 clinical trial of 48 healthy normal-weight adults, the drug was well tolerated even at the highest dose, with seven of the volunteers experiencing brief, mild drug-related side effects such as abdominal discomfort, nausea and diarrhoea.

On the basis of these results, development of the drug is continuing. The researchers expect to report the results of further animal and human studies this autumn.


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Contact: Emma Ross
rosswrite@mac.com
International Association for the Study of Obesity
Source:Eurekalert

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