Navigation Links
Experimental nonsteroidal treatment of asthma shows promise

A new nonsteroidal, anti-inflammatory therapy made from a human protein significantly decreases disease signs of asthma in mice, opening the possibility of a new asthma therapy for patients who do not respond to current steroid treatments. Results of this therapy in an animal model were presented at The Endocrine Society's 92nd Annual Meeting in San Diego.

The protein, insulin-like growth factor binding protein-3 (IGFBP-3), uniquely inhibits specific physiological consequences of asthma examined in asthmatic mice, said Youngman Oh, PhD, a study co-author and a professor of pathology at Virginia Commonwealth University, Richmond, Virginia.

IGFBP-3 reportedly targets a key cellular pathway called nuclear factor kappa B, or NF-κB that plays a role in inflammation. The IGFBP-3 protein interferes with its cellular signaling and suppresses NF-κB activity.

"This novel mechanism has never been identified before. Our findings could have major implications not only for asthma but also other inflammatory diseases that NF-κB plays a role in, such as atherosclerosis and rheumatoid arthritis," Oh said.

In asthma, when the airways become inflamed, they become hyperreactive, or overly sensitive, to "triggers," such as dust, smoke and pet dander. This leads to a chain of reactions that elicit an asthma "attack". According to the American Lung Association nearly 23 million people have asthma, of which 9 million are children.

"Anti-inflammatory corticosteroid medicines are an important part of asthma management for many people, but an estimated 20 percent of patients with asthma are resistant to existing steroid medications and there is a critical need for alternate therapies," Oh said.

Using a mouse model, Oh and his colleagues showed that IGFBP-3 production is suppressed in asthma. They measured NF-κB inflammatory activity, using molecular and cellular techniques, and found that treatment with IGFBP-3 blocked NF-κB activity.

The researchers administered IGFBP-3 to the mice by spraying a synthetic form of the protein into their opened trachea. The treatment "reduced all physiological manifestations of asthma," including airway inflammation and hyperreactivity, Oh said. His research team plans to study IGFBP-3 treatment in asthmatic canine models next.


Contact: Aaron Lohr
The Endocrine Society

Related medicine news :

1. Experimental stem cell treatment arrests acute lung injury in mice, study shows
2. Experimental Drug Offers Hope for Cystic Fibrosis Patients
3. Experimental Vaccine Shields Monkeys Against Ebola
4. Experimental targeted therapy shows early promise against medulloblastomas
5. Steroids May Be Overrated in Treatment of COPD
6. Entest BioMedical Enters into LOI with Advanced Light Devices to Develop Laser Platform for Stem Cell / Laser COPD Treatment
7. New study shows effectiveness of MEND program in prevention and treatment of pediatric obesity
8. New York City Surgeon Develops All-Natural Treatment for Wrinkles and Scars
9. Novelty lures rats from cocaine-paired settings, hinting at new treatments for recovering addicts
10. Northeast Chiropractic, PC Revolutionizes Pain Management Without Medication, Now Offering New and Unique Blend of Treatments
11. and Generation Rescue Work Together to Raise Money for Biomedical Autism Treatments
Post Your Comments:
(Date:10/13/2015)... ... 13, 2015 , ... Element Blue ™, a leading ... company, RightSensor™ LLC, an Internet of Things (IoT) hardware supplier that delivers custom ... approach for customers requiring sensor hardware for critical data environments. , RightSensor™, working ...
(Date:10/13/2015)... , ... October 13, 2015 , ... Dr. Poneh Ghasri, ... New Today on September 18, 2015. The research, which was conducted at the Dental ... Sabbah and colleagues, show connections between stress during pregnancy and future dental health in ...
(Date:10/13/2015)... ... October 13, 2015 , ... A child without a healthy mouth is much ... leading remote invisible aligner system, has joined with Global Dental Relief (GDR) ... each aligner treatment plan purchased, SmileCareClub will donate one clinic visit to a child ...
(Date:10/13/2015)... ... October 13, 2015 , ... Altec Products, Inc., the ... of Synergy 2015. The annual WennSoft KEY2ACT user conference will take place from ... unite customers, partners, WennSoft team members and sponsors to facilitate the sharing of ...
(Date:10/13/2015)... Dallas, Texas (PRWEB) , ... October 13, 2015 ... ... network headquartered in McHenry County, Illinois with more than 59,000 emergency department visits ... department information system (EDIS) from T-System, to help improve clinical, operational and financial ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 2015  Data Science Automation (DSA), a system integration and ... branch office in the United Kingdom ... Europe . The decision to open the new ... support of customers in the medical device industry throughout the ... Manager. "We have had tremendous success over the last several ...
(Date:10/13/2015)... 13, 2015  Nanomedical Diagnostics, a biotech company ... and diagnostics, announces the completion of a Series ... Serra Ventures. --> ... easy-to-use monitoring and diagnostic platforms that empower individuals ... round will enable the company to commercially release ...
(Date:10/13/2015)... , Oct. 13, 2015 Attracting mid- to large-sized ... key to growing Baltimore into a ... today by the Maryland Technology Enterprise Institute (Mtech) . ... the pieces in place to support innovation hubs and a ... of Mtech Baltimore. "This study is important because we believe ...
Breaking Medicine Technology: