Navigation Links
Experimental insulin-like growth factor receptor inhibitor reduced pancreatic cancer growth
Date:4/14/2009

PHILADELPHIA Researchers at Amgen are testing a fully human monoclonal antibody that inhibits the activity of insulin-like growth factors (IGF-1 and IGF-2) and appears to reduce pancreatic cancer cells in early testing, according to a report in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research.

Pancreatic cancer is one of the deadliest cancers, and less than 4 percent of the 200,000 patients diagnosed annually live more than five years. The only available clinical treatment is gemcitabine, but this has yet to show a survival benefit.

Scientists are testing a variety of experimental therapies to bring pancreatic cancer under control. At Amgen, Pedro J. Beltran, Ph.D., a principal scientist in oncology research, is experimenting with AMG 479, a fully human anti-IGF-1 monoclonal antibody.

"We know that insulin-like growth factors play a role in cancer development, particularly in mediating cell survival. This is the first drug that specifically targets the receptor for these growth factors without cross-reacting with the closely related insulin receptor," said Beltran.

In the in vitro study, AMG 479 bound to IGF-1R and blocked both IGF-1 and IGF-2 binding factors 1 and 2. It also completely inhibited ligand-induced activation in some growth factors, which led to a decreased cellular viability. When Beltram and colleagues measured the effect of AMG 479 on pancreatic cancer cells in vivo, the inhibition rate was approximately 80 percent inhibition of tumor growth and receptor expression was observed.

"These data clearly show that AMG 479 is a clinical candidate for pancreatic cancer therapy, either alone or in combination with gemcitabine," he said.

Beltran said researchers are currently testing AMG 479 in nine separate phase II studies of various cancer types; he expects the effect will be seen beyond pancreatic cancer.


'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
2. Experimental Antidepressants Offer Faster Relief
3. Experimental drug shows promise in advanced kidney cancer
4. Experimental drug boosts survival in recurrent ovarian cancer
5. Experimental cancer pharmaceuticals under trial
6. Experimental Drug Fails Against Heart Failure
7. Experimental Drug Fights Prostate Cancer
8. Experimental technique at GUMC offers real-time analysis of breast cancer biopsies
9. Experimental Vaccine Halts Prostate Cancer in Mice
10. Experimental Biology 2008 Todays Research: Tomorrows Health, April 5-9
11. 52 minority scientists receive travel fellowships to Experimental Biology 2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... Metro Development Group has broken ... speed technology into the fabric of an entire community. A highlight of this ... wellness in a yet-to-be-named, health focused campus. Leading this initiative in partnership with ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... – will lecture to primary eye care practitioners on the latest breakthroughs in ... upcoming 13th Semi-Annual Continuing Education Symposium, according to eye surgeon, Jeffrey Martin, MD, ...
(Date:1/17/2017)... ... January 17, 2017 , ... SC&H Group, a leading ... a Principal in its IT Advisory Services practice . Rossi is the third ... market demand for strategic IT guidance grows, and the practice continues to expand.     , ...
(Date:1/17/2017)... ... 17, 2017 , ... Lynx Technology Partners (Lynx), ... security companies for consecutive years, today announced the appointment of four members to ... nomination process to a close and positions Lynx for even faster growth in ...
(Date:1/16/2017)... ... 17, 2017 , ... Recently, patients and staff from A Forever Recovery, a ... organizations in support of the annual Binder Park Zoo Halloween celebration known as the ... costumes of all designs coming out to enjoy games, face painting, and lots and ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Advertising -- Bronstein, Gewirtz & Grossman, LLC is investigating potential ... or the "Company") (NASDAQ: ANTH ). Such investors ... by visiting the firm,s site: www.bgandg.com/anth .   ... and/or directors have violated Sections 10(b) and 20(a) of the ... ...
(Date:1/17/2017)... WASHINGTON , Jan. 17, 2017  In a ... CEO Jo Ann Jenkins outlines AARP,s priorities ... and Social Security, ensuring access to affordable health care ... In the letter Jenkins writes to President-elect Trump ... older Americans are counting on you to protect their ...
(Date:1/17/2017)... 2017 Immune Pharmaceuticals (NASDAQ: IMNP ... that it will hold a Satellite Symposium on February 20th, ... XVI in Munich, Germany . ... of Immunotherapy for the maintenance of remission in AML ... th , 2017 from 12:45 – 13:45 CET in ...
Breaking Medicine Technology: