Navigation Links
Experimental drug shows promise against head and neck cancer
Date:4/28/2009

April 28, 2009 (BRONX, NY) A laboratory study by researchers at Albert Einstein College of Medicine of Yeshiva University suggests that an anti-cancer compound studied for treating blood cancers may also help in treating cancers of the head and neck. The work is reported in the April 28th online edition of the Journal of Pathology.

Head and neck cancer refers to tumors in the mouth, throat, or larynx (voice box). Each year about 40,000 men and women develop head and neck cancer in the U.S., making it the country's sixth-most common type. Surgery, chemotherapy and/or radiation are the main treatment options but can cause serious side effects. Better treatments are needed, since only about half of patients with head and neck cancer survive for five or more years after diagnosis.

The Einstein study involved a new class of chemotherapy agents known as histone deacetylase (HDAC) inhibitors, which affect the availability of genes that are transcribed and translated into proteins. In many types of cancer, out-of-control cell growth results from certain genes that are either too active or not active enough in producing proteins. HDAC inhibitors appear to combat cancer by restoring the normal expression of key regulatory genes that control cell growth and survival.

The Einstein researchers focused on a particular HDAC inhibitor known as LBH589 that has already shown some success in clinical trials involving people with cancers of the blood. The researchers found that LBH589 succeeded in killing tumor cells that had been removed from head and neck cancer patients and grown in the laboratory.

"This report shows that an HDAC inhibitor is effective on head and neck cancer cell lines, and that is the first step toward use in humans," said Richard Smith, M.D., the lead clinician involved in the study. Dr. Smith is associate professor of clinical otorhinolaryngology-head & neck surgery and associate professor of surgery at Einstein and is also vice-chair of otorhinolaryngology-head & neck surgery at Einstein and Montefiore.

The researchers also identified a set of genes whose expression levels change in response to the HDAC inhibitorsa finding that may help doctors identify patients most likely to respond to the drug. Plans call for testing LBH589 on head and neck tumor cells from more patients so that the set of genes that respond to the drug can be more firmly established.

"We are performing studies in mice to confirm these laboratory results, which hopefully will progress to human clinical trials of LBH589 for the treatment of head and neck cancer," said Michael Prystowsky, M.D., Ph.D., chair and professor of pathology at Einstein and corresponding author of the article.


'/>"/>

Contact: Deirdre Branley
sciencenews@aecom.yu.edu
718-430-2923
Albert Einstein College of Medicine
Source:Eurekalert  

Related medicine news :

1. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
2. Experimental Antidepressants Offer Faster Relief
3. Experimental drug shows promise in advanced kidney cancer
4. Experimental drug boosts survival in recurrent ovarian cancer
5. Experimental cancer pharmaceuticals under trial
6. Experimental Drug Fails Against Heart Failure
7. Experimental Drug Fights Prostate Cancer
8. Experimental technique at GUMC offers real-time analysis of breast cancer biopsies
9. Experimental Vaccine Halts Prostate Cancer in Mice
10. Experimental Biology 2008 Todays Research: Tomorrows Health, April 5-9
11. 52 minority scientists receive travel fellowships to Experimental Biology 2008
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental drug shows promise against head and neck cancer
(Date:9/26/2017)... ... ... “Sound of My Song”: an intriguing and thought-provoking on love, life, and ... retired teacher with a passion for music and ancestral history. , Published by ... loss, living with depression, and finding love through the journey. There is powerful imagery ...
(Date:9/26/2017)... ... ... the life story of the author and the exciting times this adventurer has lived through. ... tour guide and the subject of the book. , “Quickly slapping a large smile ... played it off as a part of the adventure tour, an “added bonus” story they ...
(Date:9/26/2017)... ... September 26, 2017 , ... Time out for Daddy is a moving ... understanding that even grownups make mistakes. “Time Out for Daddy” is the creation of ... entire life and whose passion for children inspired her to write this book. , ...
(Date:9/25/2017)... Texas (PRWEB) , ... September 25, 2017 , ... ... VitalBand, the first and only fully programmable fall detection smart watch. VitalBand ... as many critical contacts as you want so help arrives quickly. Plus, ...
(Date:9/25/2017)... Reston, VA (PRWEB) , ... September 25, 2017 ... ... mobile application security, today announced its latest release of SentinelSecure™, version 3.0, will ... website Secure.Systems . This newest version of SentinelSecure™ comes with several new ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)...  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... it will be participating in the Morgan Stanley 15 ... Hyatt hotel in New York.  Zimmer Biomet will present ... Time. A live webcast of the presentation ... at http://investor.zimmerbiomet.com .   ...
(Date:9/6/2017)... SAN ANTONIO , Sept. 6, 2017  Robert ... as a Pinnacle Professional Member in recognition of his ... Dr. Szewc serves as a Nephrologist at the practice ... services, emergency medicine, kidney care and hypertension solutions. He ... over 20 years of career experience, as well as ...
(Date:9/6/2017)... PDI , a leader in infection prevention products and ... focused on the role of chlorhexidine gluconate (CHG) in ... Annual Scientific Meeting of the Association for Vascular Access. ... Phoenix Convention Center in ... feature PDI,s Prevantics® Device Swab as the ...
Breaking Medicine Technology: