Navigation Links
Experimental drug prolongs life span in mice
Date:5/1/2014

CHICAGO --- Northwestern Medicine scientists have newly identified a protein's key role in cell and physiological aging and have developed in collaboration with Tohoku University in Japan -- an experimental drug that inhibits the protein's effect and prolonged the lifespan in a mouse model of accelerated aging.

The rapidly aging mice fed the experimental drug lived more than four times longer than a control group, and their lungs and vascular system were protected from accelerated aging, the new study reports.

The experimental drug could potentially be used to treat human diseases that cause accelerated aging such as chronic kidney disease, diabetes and HIV infection as well as the effects of cigarette smoking.

"A drug like this could help reduce complications in clinical conditions that reflect accelerated aging," said Douglas Vaughan, M.D., senior author of the study. "This had a very robust effect in terms of prolonging life span."

Vaughan is the chair of medicine and the Irving S. Cutter Professor at Northwestern University Feinberg School of Medicine and physician-in-chief at Northwestern Memorial Hospital.

This is a completely different target and different drug than anything else being investigated for potential effects in prolonging life, Vaughan noted.

While the experimental drug is in the early stages of testing, Vaughan said, "It makes sense that this might be one component of a cocktail of drugs or supplements that a person might take in the future to extend their healthy life."

The study was published April 28 in Proceedings of the National Academy of Sciences.

The experimental drug, TM5441, is one of only several chosen each year by the National Institute on Aging to be tested in its Interventions Testing Program, which investigates treatments with the potential to extend lifespan and delay disease in mice.

The discovery is the result of 25 years of research by Vaughan's lab.

When cells or tissue age -- called senescence -- they lose the ability to regenerate and secrete certain proteins, like a distinctive fingerprint. One of those proteins, PAI-1 (plasminogen activator inhibitor) has been the focus of Vaughan's research, originally as it relates to cardiovascular disease.

"We made the intellectual leap between a marker of senescence and physiological aging," Vaughan said. "We asked is this marker for cell aging one of the drivers or mechanisms of rapid physiological aging?"

For the study, he and colleagues used mice bred to be deficient in a gene (Klotho) that suppresses aging. These mice exhibit accelerated aging in the form of arteriosclerosis, neurodegeneration, osteoporosis and emphysema and have much shorter life spans than regular mice. Vaughan determined that these rapidly aging mice produce increased levels of PAI-1 in their blood and tissue.

Then scientists fed the rapidly aging mice TM5441 -- the experimental drug -- in their food every day. The result was a decrease in PAI-1 activity (the aging protein Vaughan's team had identified), which quadrupled the mice's life span and kept their organs healthy and functioning.

Northwestern scientists also genetically produced the same life prolonging results when they crossed the mice deficient in the age-suppressing gene with mice deficient in PAI-1. Importantly, partial genetic deficiency of PAI-1 and the experimental PAI-1 antagonist produced provided similar benefits in the mice, Vaughan noted.


'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. Experimental drug shows promise for treatment-resistant leukemias
2. Diabetes drug shows promise in reducing Alzheimers disease in an experimental model
3. Experimental drug could enhance multiple myeloma and myeloid leukemia therapies
4. Experimental drug shows encouraging results in treating most common form of lung cancer
5. Studies of experimental hepatitis C drug show promise for preventing recurrence in liver transplant
6. ASSURE study of experimental agent to raise HDL yields disappointing and surprising results
7. York physicists offer novel insight into experimental cancer treatment
8. Experimental Drug Shows Benefits Against Melanoma in Early Study
9. Experimental Drugs Show Promise Against Prostate Cancer
10. Experimental Drug Seems to Aid Memory in Mice With Alzheimers
11. Mayo Clinic finds experimental drug inhibits growth in all stages of common kidney cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... Washington, DC (PRWEB) , ... March 30, 2017 ... ... scientists and organizations submitted a letter to President Trump expressing their support for ... two medical doctors, two Ph.D. scientists and one medical journalist, will hold a ...
(Date:3/29/2017)... York City, NY (PRWEB) , ... March 29, ... ... body for men’s and women’s professional squash, announced it has enlisted New York ... partner. The agency will develop and procure sponsorship opportunities for the Professional ...
(Date:3/29/2017)... Amherst, Massachusetts (PRWEB) , ... March 30, 2017 , ... ... has had great success and feedback from high school and college students who have ... is being held July 7-23 and YFI is now accepting applications for enrollment. ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... a Walgreens store in Mississippi. AngioGenesis Labs, makers of HeartBoost, BrainBest and BeautyBest, ... southeastern states. Ingredients in HeartBoost, an over the counter heart healthy drink, can ...
(Date:3/29/2017)... ... March 29, 2017 , ... Dr. Angela Cotey, a noted general ... accepting new pediatric patients, with or without a referral. Dr. Cotey knows that ... orthodontic outcome and experience. When patients receive early treatment, they may achieve straight teeth ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... Mar. 29, 2017 Research and Markets ... Market 2014 - 2025" report to their offering. ... The ... 303.7 million by 2025. Increasing geriatric population prone to orthopedic ... orthopedic navigation systems over the forecast period. Osteoarthritis and osteoporosis ...
(Date:3/29/2017)... , March 29, 2017  Experts in ... remote monitoring devices like  Soberlink Systems  as a ... consensus paper, published in early 2017, concluded that ... valuable in managing patient recovery." The ... Journal of Addiction Medicine, detail a range of ...
(Date:3/29/2017)...  Glenmark Pharmaceuticals, a global pharmaceutical company, today ... fixed-dose combination of mometasone furoate (25 mcg) and ... nasal spray being studied for the treatment of ... recently completed Phase 3 trial assessing the efficacy ... mometasone, olopatadine or placebo. "We continue ...
Breaking Medicine Technology: