Navigation Links
Experimental drug more potent, longer lasting than morphine
Date:1/4/2011

MAYWOOD, Ill. -- A little-known morphinelike drug is potentially more potent, longer lasting and less likely to cause constipation than standard morphine, a study led by a Loyola University Health System anesthesiologist has found.

The drug, morphine-6-0-sulfate, has a similar chemical structure to standard morphine. Dr. Joseph Holtman Jr. and colleagues reported that a study they performed in rats "demonstrated potential clinical advantages of morphine-6-0-sulfate compared to morphine."

Holtman is first author of the study, published in the December 2010 issue of the European Journal of Pharmacology.

Holtman is medical director of Loyola's Pain Specialty Service and a professor in the departments of Anesthesiology and Molecular Pharmacology and Therapeutics of Loyola University Chicago Stritch School of Medicine. He directed the study while he was at the University of Kentucky's College of Medicine. He joined Loyola on March 1, 2010.

Opioids, such as morphine, oxycodone and hydrocodone, are standard drugs for treating moderate to severe pain, including cancer pain. But these drugs can have significant side effects, including constipation, nausea, vomiting, drowsiness, cognitive dysfunction and slowed breathing and heart rates. And while opioids work well for conditions such as back pain and post-operative pain, the drugs are less effective against neuropathic pain, such as tingling, burning or shooting pain.

Constipation is a common side effect of morphine and can be so uncomfortable that some patients limit their use of the drug. Doctors typically do not discharge surgery patients until they have had a bowel movement and this can extend hospital stays.

Holtman and colleagues tested standard morphine and morphine-6-0-sulfate on rats. The animals received the drugs three ways -- by mouth, by IV and by injection into the space surrounding the spinal cord.

The rats underwent several well-estab
'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Experimental vaccine sets sights on lung cancer
2. Experimental Drug Raises Good Cholesterol Levels in Early Trial
3. UT Southwestern researchers create experimental vaccine against Alzheimers
4. Experimental Drug Aids Kids With Nervous System Tumor
5. Experimental Test May Spot Prostate Cancer Earlier, More Accurately
6. Experimental Leukemia Drug Proves a Slam Dunk
7. Experimental Drug Shows Promise for Bone Marrow Disorder
8. Experimental TB Test Called Fast and Accurate
9. Experimental treatments for cocaine addiction may prevent relapse
10. Experimental obesity drug avoids brain effects that troubled predecessors
11. Experimental nonsteroidal treatment of asthma shows promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Minn. (PRWEB) January 22, 2015 Blue Cross ... those Minnesotans who exemplify what it means to “Live Fearless.” ... chance for people to share their stories about how they ... or simply inspired others by living in the moment. By ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David Leadbetter ... to bestow a Juvent Sports Achievement award upon an ... The award commemorated and congratulated McKitrick for her record ... her first amateur tournament in 1979 and most recently ...
(Date:1/22/2015)... January 22, 2015 Autocarinsurancebest.com has released a ... a commercial auto insurance policy . , Auto insurance ... vehicles. It is no longer necessary to call an agent ... now available online on a single website: http://autocarinsurancebest.com/ . ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved ... upcoming 32nd Annual Miami Breast Cancer Conference ... LLC (PER®) , shares that “a fast-growing, virulent” cancer ... she had not followed up her clean mammogram with ...
(Date:1/22/2015)... 23, 2015 Recently, Weddingshe.com has added many ... has announced its highest annual revenues in the past three ... popular glamorous wedding dresses. , According to the sales manager ... dress promotions for them in 2015. This point can be ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... ... retail sites. , ... (PRWEB) May 26, 2010 -- Buckts Firefox Add-on delivers discounts and coupons for over ... a shopper visits an online retailer, clicking on the highlighted ShoppingBuckt icon from the ...
... ... to assess up to $100,000 per-violation penalties , ... Alexandria, VA (Vocus) May 26, 2010 -- More than ... Certificate Exchange Network (CEN) offered by the National Association of Chain Drug Stores (NACDS) ...
... ahead of expected changes to oversight of supplement industry ... investigation of dietary herbal supplements has found trace amounts ... all products tested, plus myriad illegal health claims made ... reported Wednesday. , The levels of heavy metal contaminants ...
... sex hormones, such as testosterone, have well defined roles in ... that they also play an important role in female fertility. ... male sex hormones in the ovaries helps regulate female fertility, ... of follicles that contain growing eggs. This study ...
... disease are not only at risk for serious heart-related ... regardless of the type of surgical intervention they receive ... study by Nationwide Children,s Hospital, and appearing in ... ahead of print. Necrotizing enterocolitis (NEC) is ...
... ... mistake in Ohio. , ... NY (PRWEB) May 10, 2010 -- Embryo mix-ups at fertility clinics are extremely uncommon. However, when ... involved., , , , ,A doctor had given Carolyn Savage the wrong embryo and she became ...
Cached Medicine News:Health News:Retailers and Manufacturers Quickly Adopt Online Network to Address CPSIA Compliance 2Health News:Retailers and Manufacturers Quickly Adopt Online Network to Address CPSIA Compliance 3Health News:Many Supplements Said to Contain Toxins, Make False Health Claims 2Health News:Male sex hormones in ovaries essential for female fertility 2Health News:Male sex hormones in ovaries essential for female fertility 3Health News:Study sheds light on deadly GI disease in infants born with complex congenital heart disease 2Health News:Study sheds light on deadly GI disease in infants born with complex congenital heart disease 3Health News:An Embryo Mix up Would Involve New York Medical Malpractice Lawyers 2
(Date:1/22/2015)... Jan. 22, 2015 Increasing sophistication among enterprise buyers ... localization purchasing in 2015, says Moravia CMO, ... recent study by market research firm Common Sense Advisory, ... for their translation and localization needs. "From a language ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... of the "Microbiology Testing/Clinical Microbiology Market by ... Forecast to 2019" report to their offering. ... array of techniques for the detection of infectious ...
(Date:1/22/2015)... BETHESDA, Md. , Jan. 22, 2015 The Parenteral ... Manufacturing Science Program SM : Enabling Pharmaceutical Manufacturing,s Future. ... will fulfill the following goals: , Highlight the ... , Strengthen and build practical solutions by filling known gaps ...
Breaking Medicine Technology:Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 3PDA Launches Manufacturing Science Program(SM) 2PDA Launches Manufacturing Science Program(SM) 3
... 2007 /PRNewswire/ --,An activity-based cost analysis demonstrated that ... weeks replaced thrice weekly,administration of epoetin alfa, hemodialysis ... more than $44,000 per year per 100,patients. These ... in hemodialysis patients, were presented today,during an oral ...
... Md., April 23, 2007--A part of the brain ... thinner in youth with a risk gene for ... the National Institute of Mental,Health (NIMH), one of ... thinner entorhinal cortex, a structure in the lower ...
Cached Medicine Technology:Prospective Model Outlined Potential Time and Cost Savings of,Once-Monthly Anemia Treatment 2Prospective Model Outlined Potential Time and Cost Savings of,Once-Monthly Anemia Treatment 3Cortex Area Thinner in Youth with Alzheimers-Related Gene 2Cortex Area Thinner in Youth with Alzheimers-Related Gene 3Cortex Area Thinner in Youth with Alzheimers-Related Gene 4
Triturus® is an open and completely automated ELISA immunoassay analyzer which can perform a variety of different tests on a series of samples and process several batches simultaneously....
... The current available techniques for prenatal diagnosis ... with their use a small but significant ... current standard care offers invasive prenatal baby ... risk of chromosomal or genetic abnormalities are ...
Custom Pediatric Nebulizer Assembly W/Tubing...
... only HER-2 assessment test approved by the ... three claims: prognosis, adriamycin-based chemotherapy selection and ... is the only FISH-based DNA probe HER-2 ... as an appropriate test to aid in ...
Medicine Products: