Navigation Links
Experimental drug may extend therapeutic window for stroke
Date:7/17/2012

company's 3K3A-APC is a genetically engineered variant of the naturally occurring activated protein C (APC), which plays a role in the regulation of blood clotting and inflammation. APC has cell-protecting, anti-inflammatory and anti-coagulant properties; 3K3A-APC has reduced anti-coagulant ability, which minimizes the risk of bleeding induced by normal APC. The protective effect of 3K3A-APC on the lining of blood vessels in the brain further helps prevent bleeding caused by tPA.

In collaboration with the University of Rochester Medical Center, Henry Ford Health Sciences Center, University of Arizona College of Medicine and The Scripps Research Institute, Zlokovic and his team gave tPA alone and in combination with 3K3A-APC to mice and rats four hours after stroke. They also gave 3K3A-APC for three consecutive days after stroke. They measured the amount of brain damage, bleeding and motor ability of the rodents up to seven days afterward.

The researchers found that, under those conditions, tPA therapy alone caused bleeding in the brain and did not reduce brain damage or improve motor ability when compared to the control. The combination of tPA and 3K3A-APC, however, reduced brain damage by more than half, eliminated tPA-induced bleeding and significantly improved motor ability.

"Dr. Zlokovic's study really demonstrates the promise of the drug and we are eager to show the same results in human clinical trials," said Kent Pryor, Ph.D., M.B.A., ZZ Biotech's chief operating officer.

Previous research suggests that the experimental drug may also protect against other neurological maladies such as amyotrophic lateral sclerosis and traumatic brain injury as a standalone therapy.

"We are encouraged by these results," said Joe Romano, CEO and president of ZZ Biotech. "In terms of improving treatment for stroke and other neurological diseases, this could be really exciting."


'/>"/>

Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California - Health Sciences
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Experimental Chemo Combo for Colon Cancer Disappoints
2. Experimental Pill for Multiple Sclerosis Shows Promise
3. Experimental Gel May Help Those With Advanced Parkinsons
4. Experimental Drug Eases Autistic Behaviors in Mice
5. Experimental Drug Helps Fight Some Childhood Cancers, Study Finds
6. Experimental drug improves muscle strength among male cancer patients
7. Experimental Vaccine Seems to Stop Nicotine Addiction in Mice
8. Content Writing King Announces Cancellation Of Experimental Video Creation Process For Their Article Marketing Website
9. Fertility preservation with cryopreservation of ovarian tissue: from experimental to mainstream
10. Healthy Behaviors Extend Life After Cancer, Experts Say
11. Exercise and a healthy diet of fruits and vegetables extends life expectancy in women in their 70s
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... IMED Mobility, a premier provider of wheelchair ... recording artist Michelle Murray on Thursday, June 20th 2 p.m to ... Line” music and movie tour, which shares the story of Sam ... the track in 2000. Much of the film takes place on ... sport of INDYCAR racing despite suffering a crash that left him ...
(Date:5/23/2013)... Magnatag’s new magnetic 365-Day attendance and vacation ... conflicts. A Manufacturing Manager from Augusta GA told us, ... and managers can check the board for themselves and ... to us and the board makes the record public ... but it has made a difference.” , “Our ...
(Date:5/23/2013)... 2013 Magic often happens unexpectedly. "Howie ... of precocious twin five-year olds, Howie and his sister Heather, ... a case in point. May 23, 2013 marks the debut ... to coincide with the start of the Resort's "WeTime/MeTime” ... tons of amenities and, most precious of all, opportunities for ...
(Date:5/23/2013)... Whether working in an urban setting ... enforcement need an added layer of protection at night. ... VISER , is an effective portable, rugged, rapidly deployable ... increase border and perimeter security. , Today, ARA announces ... tripled over the past three years, with most systems ...
(Date:5/23/2013)... May 24, 2013 On March 14, 2012, ... women will hear in her lifetime: she had breast cancer. ... Journey After a Breast Cancer Diagnosis ” (published by AuthorHouse), ... , Rideout drew from her daily journals to give readers ... surgery, chemotherapy and radiation treatments to deal with stage two ...
Breaking Medicine News(10 mins):Health News:Local Mobility Dealer Hosts Nashville Recording Artist 2Health News:New Attendance, Vacation and Training Tracker Board Reduces Employee Conflicts and Improves Attendance 2Health News:New Children's Comic Book, "Howie Goes to Maui," Launches May 23, 2013 On Four Seasons Resort Maui's Web Site 2Health News:New Children's Comic Book, "Howie Goes to Maui," Launches May 23, 2013 On Four Seasons Resort Maui's Web Site 3Health News:Lighting Up the Night: ARA Announces Record Sales of Its Night VISER System 2Health News:Lighting Up the Night: ARA Announces Record Sales of Its Night VISER System 3Health News:Kimberley Rideout Shares Her Triumphant Cancer Survival Story 2
... systematic reviews of the evidence base for health care ... and organizations authoritative guidance on the comparable pros and ... are of uncertain or poor quality. There are ... clinical practice guidelines, leading to variability in the handling ...
... This press release is available in French . ... the ages of 20 and 90 years old. While some cells ... and redundancy. Based on the results of her most recent clinical ... Journal of Neurology, Dr. Sylvie Belleville, PhD in neuropsychology, the ...
... the discovery of a "golden ratio" in the nanoscale ... new suggestion that matter on the quantum level may ... chaos. Stories on the health sciences and medicine ... The most popular topics varied from neurological diseases including ...
... , TUESDAY, March 22 (HealthDay News) -- Trauma injury ... a weeknight are no more likely to die than those ... The findings contrast with previous research that said patients ... worse outcomes if they arrive at the hospital at night ...
... MD A recent study accepted for publication in The Endocrine ... found that higher levels of perfluorocarbons (PFCs) in the body ... women between 42 and 64 years old. Women in this ... lower concentrations of estrogen when compared to women who had ...
... FOR MARCH 23, 2011] Norovirus is the leading cause of ... cause nearly 21 million cases annually. It is highly ... surfaces. The results of an investigation of a 2009 ... infections can spread and the steps both passengers and crew ...
Cached Medicine News:Health News:IOM recommends standards to achieve reliable clinical practice guidelines 2Health News:IOM recommends standards to achieve reliable clinical practice guidelines 3Health News:Subjects at risk of Alzheimer's may now be able to delay the onset of their first symptoms 2Health News:Physics story tops EurekAlert!'s 2010 list of most-visited releases 2Health News:Physics story tops EurekAlert!'s 2010 list of most-visited releases 3Health News:Physics story tops EurekAlert!'s 2010 list of most-visited releases 4Health News:Physics story tops EurekAlert!'s 2010 list of most-visited releases 5Health News:Trauma Patients Seem More Likely to Survive on Weekends 2Health News:Exposure to chemicals in environment associated with onset of early menopause 2Health News:Cruise ship norovirus outbreak highlights how infections spread 2
(Date:5/24/2013)...  Sinovac Biotech Ltd. (NASDAQ: SVA ... China , announced that Sinovac ... obtained the Certificate of Good Manufacturing Practices for ... and Food Administration (CFDA) for its proprietary vaccines, ... Changping filing and packaging facility. The GMP certificate ...
(Date:5/23/2013)... DIEGO y PARÍS, 24 de mayo ... VOLC ), un destacado desarrollador y fabricante de ... mejorar la diagnosis y tratamiento de la enfermedad ... preliminares del ensayo ADVISE ( Ad enosine ... E valuation) II durante la sesión de ...
(Date:5/23/2013)... Hearing health affects a man,s lifestyle, and if ... and professionally engaged, he should address any hearing loss he ... Better Hearing Institute (BHI) is delivering to men ... Week , which leads up to and includes Father,s Day. ... through June 16. To help men address ...
Breaking Medicine Technology:Sinovac Beijing Obtains China GMP Certificate Under the New GMP Guidelines 2Sinovac Beijing Obtains China GMP Certificate Under the New GMP Guidelines 3Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 2Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 3Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 4Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 5Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 6Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 2Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 3Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 4
... , PRINCETON, N.J., Nov. 9 Pharmasset, Inc. (Nasdaq: ... Lazard Capital Markets Healthcare Conference. The conference will be held ... 17-19, 2009). , Schaefer Price, Pharmasset,s President and Chief Executive ... November 18, 2009 at 3:45 PM (ET). , To access ...
... 9 Par Pharmaceutical Companies, Inc. (NYSE: PRX ... date and increased the purchase price of its previously ... is offering to purchase, for cash, up to $65,000,000 ... its outstanding 2.875% Senior Subordinated Convertible Notes due 2010. ...
Cached Medicine Technology:Pharmasset to Present at Lazard Capital Markets Healthcare Conference 2Pharmasset to Present at Lazard Capital Markets Healthcare Conference 3Par Pharmaceutical Announces Extension and Increase in Maximum Purchase Price for 'Modified Dutch Auction' Tender Offer to Purchase up to $65,000,000 Aggregate Principal Amount of its Currently Outstanding 2.875% Senior Subordinated Convertible Note 2Par Pharmaceutical Announces Extension and Increase in Maximum Purchase Price for 'Modified Dutch Auction' Tender Offer to Purchase up to $65,000,000 Aggregate Principal Amount of its Currently Outstanding 2.875% Senior Subordinated Convertible Note 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: