Navigation Links
Experimental drug could enhance multiple myeloma and myeloid leukemia therapies
Date:2/18/2014

A pre-clinical study led by Virginia Commonwealth University Massey Cancer Center and Department of Internal Medicine researchers suggests that an experimental drug known as dinaciclib could improve the effectiveness of certain multiple myeloma and myeloid leukemia therapies. The study, recently published in the journal Molecular Cancer Therapeutics, showed that dinaciclib disrupted a cell survival mechanism known as the unfolded protein response (UPR). Without the UPR, multiple myeloma and myeloid leukemia cells were unable to combat damage caused by some anti-cancer agents.

"Although dinaciclib has shown promising pre-clinical activity against a variety of tumor cells, and is currently undergoing phase I/II clinical trials in several malignancies, the mechanisms responsible for its anti-tumor activity are not fully understood," says the study's lead investigator Steven Grant, M.D., associate director for translational research, co-leader of the Developmental Therapeutics research program and Shirley Carter Olsson and Sture Gordon Olsson Chair in Oncology Research at Massey. "Our research highlights a potentially new mechanism of dinaciclib action, and raises the possibility that this agent could be a useful addition to current multiple myeloma and myeloid leukemia therapies."

Dinaciclib is a member of a class of drugs known as cyclin-dependent kinase (CDK) inhibitors. CDKs regulate a series of events known as the cell cycle, or cell-division cycle, that lead to the division and duplication of cells. In many cancers, CDKs are overactive or CDK-inhibiting proteins are not functional, which results in the unregulated proliferation of cancer cells. Laboratory observations from this study suggest that two specific CDKs, CDK1 and CDK5, play key roles in regulating the UPR by helping to control the production and accumulation of a protein known as X-box binding pretein-1 (XBP-1).

The spliced form of XBP-1 (XBP-1s) helps regulate t
'/>"/>

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Experimental Chemo Combo for Colon Cancer Disappoints
2. Experimental Pill for Multiple Sclerosis Shows Promise
3. Experimental Gel May Help Those With Advanced Parkinsons
4. Experimental Drug Eases Autistic Behaviors in Mice
5. Experimental Drug Helps Fight Some Childhood Cancers, Study Finds
6. Experimental drug improves muscle strength among male cancer patients
7. Experimental Vaccine Seems to Stop Nicotine Addiction in Mice
8. Content Writing King Announces Cancellation Of Experimental Video Creation Process For Their Article Marketing Website
9. Fertility preservation with cryopreservation of ovarian tissue: from experimental to mainstream
10. Experimental drug may extend therapeutic window for stroke
11. Experimental Chemical Helps Blind Mice See
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental drug could enhance multiple myeloma and myeloid leukemia therapies
(Date:7/30/2014)... Daily Gossip indicates in its 60 Second Panic ... attack is a feeling of intense stress and fear, which ... of symptoms that sufferers commonly deal with when panic attacks ... or anxiety. Naturally, panic attacks deeply affect lifestyle; this is ... them. , The 60 Second Panic Solution review promises to ...
(Date:7/30/2014)... and Malaysia (PRWEB) July 30, 2014 ... through education by LTT Global an award winning mobile ... learning on the go since 2004. , MyMobileUni.com’s platform ... quality learning content. MMU has links to the ... organizations, NGOs’ and subject matter experts from all over ...
(Date:7/30/2014)... 2014 Nationally recognized leader in nursing ... since September 2013 has served as president of the ... dean of the College of Nursing at University of ... leadership of the NLN, as the nation's premier voice ... nursing and research institutions in the country. , ...
(Date:7/30/2014)... weeks freshman will begin to pour onto college campuses, each student ... time of growth and the start to something big. Statistically speaking, ... as easy as it looks. Some sources cite as ... once and many will switch two or three times. Each switch ... switching in the later years of college. According to the ...
(Date:7/30/2014)... 30, 2014 Throughout the month of ... free oral cancer screenings. Using a new technological tool ... detect the disease in its early stages. , Oral ... mouth, sinuses, throat and other areas in and around ... Epidemiology, and Ends Results (SEER) program, 30 percent of ...
Breaking Medicine News(10 mins):Health News:60 Second Panic Solution Review Reveals Unique Way to Stop Panic Attacks 2Health News:MyMobileUniversity Inviting Individuals, Who Are Passionate about the Universal Right to Education, to Come on Board as Goodwill Ambassadors 2Health News:MyMobileUniversity Inviting Individuals, Who Are Passionate about the Universal Right to Education, to Come on Board as Goodwill Ambassadors 3Health News:National League for Nursing Congratulates League President Marsha Adams on Appointment as Dean of College of Nursing at University of Alabama-Huntsville 2Health News:National League for Nursing Congratulates League President Marsha Adams on Appointment as Dean of College of Nursing at University of Alabama-Huntsville 3Health News:Advice to College Freshman from Author Garrett Miller 2Health News:Advice to College Freshman from Author Garrett Miller 3Health News:Restore Dental Offers Complimentary Oral Cancer Screenings in August 2
... actress and wife of Brad Pitt has commissioned US ... to celebrate the different stages of her pregnancy. ... her request. About the portrait. ,The painting are ... in Angelinas private collection." ,Bachardy is a ...
... pain's ability to seek attention. ,The ... is distinct from the one involved in cognitive processing ... ,The study was conducted by a team of researchers ... Center Hamburg-Eppendorf. ,As part of the study, ...
... at the Stanford University School of Medicine have identified one ... and treatments for depression converge. Scientists hunt for the ... so many treatments with different mechanisms that the condition remains ... rats the differing mechanisms of depression and its treatment in ...
... of five major breast cancer trials has confirmed that ... improves survival in women with operable HER-2 positive breast ... Dahabreh from the University of Athens reported the results ... 13,000 women whose breast cancer was amenable to surgery. ...
... designed by scientists to be safe to normal tissue but ... preliminary study, researchers said today at the ESMO Conference Lugano ... type of herpes simplex virus modified so that it selectively ... ,It doesnt replicate in normal, healthy cells, so our ...
... An Australian suffered injuries to a thigh and three other ... tourists celebrated the start of the nine-day San Fermin bullrun. ... alcohol and the "encierro", when bulls are released onto the ... (yard) course leading to the arenas where bullfights are later ...
Cached Medicine News:Health News:Researchers Say Brain Region Responsible for Pain's Ability to Seek Attention 2Health News:Brain Pathway for Depression Revealed 2Health News:Brain Pathway for Depression Revealed 3Health News:Combination of Tratuzumab and Chemotherapy Yields Better Results for Breast Cancer 2Health News:New Cancer Fighting Virus 2
(Date:7/30/2014)...   Unique Pizza and Subs Corporation ... a Delaware Corporation, is pleased to announce it ... Corporation ("Larasan"), a nature-based pharmaceutical company that produces and ... Larasan will work with Unique to help distribute ... vast distribution network throughout China ...
(Date:7/30/2014)... July 30, 2014 Silicon Valley Bank, the ... study today that examines the merger, acquisition and ... companies.  According to the annual report based on 2013 ... returns since SVB started tracking the data in 2005. ... Built on solid healthcare M&A activity over the last ...
(Date:7/30/2014)... LONDON , July 30, 2014  Lightlake ... developing addiction treatments based on its expertise in ... a funding commitment from a prominent international research ... a focus on promoting innovative research-based initiatives, including ... a nasal spray for the delivery of naloxone ...
Breaking Medicine Technology:Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 3Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 3Lightlake Therapeutics Inc. Receives Funding Commitment From A Prominent International Research And Development Foundation 2Lightlake Therapeutics Inc. Receives Funding Commitment From A Prominent International Research And Development Foundation 3
... prioritization -, LOUISVILLE, Colo., Dec. 10 ... announced an operational restructuring to align,critical resources ... partner for Replidyne,s late-stage antibiotic, faropenem,medoxomil (faropenem), ... exploring additional corporate development opportunities., The ...
... outcomes for premature babies, FORT WORTH, Texas, ... Now, they are helping improve the care of,premature ... care unit recently implemented the use of the ... results in decreasing the,incidence of chronic lung disease ...
Cached Medicine Technology:Replidyne Provides Strategic Update 2Replidyne Provides Strategic Update 3Replidyne Provides Strategic Update 4Replidyne Provides Strategic Update 5Replidyne Provides Strategic Update 6Harris Methodist Fort Worth Hospital Using Bubbles to Help Babies Breathe 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: