Navigation Links
Experimental drug achieves unprecedented weight loss
Date:4/10/2011

959, and topiramate, marketed under the trade name Topamax, in doses up to 400mg to treat epilepsy and prevent migraines. Patients in the study also received diet and exercise advice.

The study was funded by Vivus, which is seeking FDA approval to market the combination therapy under the trade name Qnexa. In October 2010, the FDA ruled that the New Drug Application could not be approved in its current form, and asked the company for more safety data.

In March, the FDA issued a warning regarding the use of topiramate during pregnancy stating that pregnant women who take the drug are at considerably increased risk of having babies born with cleft lip and/or cleft palate. Topiramate has also been associated with memory problems and mood changes, including depression and anxiety.

Gadde says 34 women became pregnant while in Qnexa clinical trials, and "no birth defects were reported for the babies born." Even so, Gadde says pregnant women would not be candidates for use of this drug because "there is no reason for women to use weight loss drugs while they are pregnant or trying to become pregnant."

The study used once-daily oral doses of the combined drugs. Phentermine 7.5mg plus topiramate CR 46mg achieved 7.8 percent weight loss (p<0.0001 vs placebo). Phentermine 15mg plus topiramate CR 92mg achieved 9.8 percent weight loss (p<0.0001 vs placebo). The placebo group experienced 1.2 percent weight loss.

The greatest improvement in cardiovascular disease and diabetes were seen in high risk patients among the groups given placebo, phentermine 7.5mg plus topiramate 40mg, or phentermine 15mg plus topiramate 92mg respectively:

  • Systolic blood pressure: -4.9mmHg, -6.9mmHg, -9.1mmHg
  • Diastolic blood pressure: -3.9mmHg, -5.2mmHg, -5.8mmHg
  • Total cholesterol: -4.9%, -5.7%, -7.8%
  • LDL: -3.6%, 0.7%, -4.3%
  • HDL: 2.8%, 9.5%, 10.7%
  • Triglycerides: -8.8%, -24.1%, -25.6%
  • Hemoglobin A1C in diabetics:
    '/>"/>

Contact: Debbe Geiger
debbe.geiger@duke.edu
919-660-9461
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Science at a glance: Symposia, research and special events at Experimental Biology 2011
2. A new experimental diagnostic test able to quickly distinguish infection from tuberculosis disease
3. Extra Tests Not a Deterrent to Experimental Cancer Therapy
4. 2 Experimental Drugs Show Promise for Rare Pancreatic Cancer
5. Experimental approach may improve healing of diabetic wounds and bed sores
6. Study raises safety concerns about experimental cancer approach
7. First liver transplant patients receive experimental drug to prevent hepatitis C infection
8. Experimental Drug Helps Fight Aggressive Breast Cancer: Report
9. Experimental drug more potent, longer lasting than morphine
10. Experimental vaccine sets sights on lung cancer
11. Experimental Drug Raises Good Cholesterol Levels in Early Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... The American Gastroenterological Association (AGA) Research Foundation ... Scholars. The AGA Research Scholar Awards program, launched ... and productive research careers in digestive diseases. This ... additional year allowing for three consecutive years of ... faculty who are paving the way for promising ...
(Date:4/23/2014)... led by a researcher from the Cancer Science Institute ... Singapore has identified the cancer specific stem cell which ... of developing new drugs for the treatment of this ... group, led by Dr Chan Shing Leng, Research Assistant ... that a cancer-specific variant of a cell surface protein, ...
(Date:4/23/2014)... Previous studies have shown that proliferation of endogenous ... damage to neurons and axons. From the perspective ... from Sun Yat-sen University in China observed the ... neural precursor cell proliferation and expression of basic ... the rat brain on the infarct side. The ...
(Date:4/22/2014)... Over the last few decades researchers have characterized a ... physiology and behavior in all types of species, from ... been identified, but researchers surmise there are more. A ... University of Pennsylvania wondered if big-data approaches could find ... led by John Hogenesch, PhD, professor of Pharmacology and ...
(Date:4/22/2014)... April 22, 2014: The Association for Molecular Pathology ... Journal of Molecular Diagnostics on recommendations for ... and master,s levels of education. The report was ... Task Force of the AMP Training and Education ... need of educating future medical laboratory scientists appropriately ...
Breaking Medicine News(10 mins):Health News:AGA announces 2014 Class of AGA Research Scholars 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 3Health News:Bioinformatics profiling identifies a new mammalian clock gene 2Health News:AMP publishes curriculum recommendations for medical laboratory scientists 2
... , ... ago to help her lose weight after the birth of her last child. At just ... valves were so severely damaged because of the diet drug. , ... Pocatello, ID (PRWEB) April 8, 2010 -- Pocatello resident Cindy Cartwright knows ...
... , ... HyGreen™ has been recognized in the 2010 Medical Design Excellence Awards competition, one of ... ... Xhale Innovations’ HyGreen™ has been recognized in the 2010 Medical Design Excellence ...
... ... the clamorous demand for greater social and environmental accountability and meet the UN-set goal ... their concerns and showcase their successes. , ... (PRWEB) April 8, 2010 -- A major national conference on ...
... Acclaimed workforce ... , ... -- As budget-conscious companies look for creative ways to reduce employee turnover, cut back on ... growing trend. Billed as a progressive workplace benefit, PRtW is designed to smooth the transition ...
... with an increased risk of stroke in middle-aged and ... a landmark study supported by the National Heart, Lung, ... Health. Overall, sleep apnea more than doubles the risk ... common disorder in which the upper airway is intermittently ...
... ... ... During the month of April, AthletiCo Physical Therapy and Occupational Therapy celebrates ... occupational/hand therapists are the premier specialists in treating upper extremity diagnoses. , , ...
Cached Medicine News:Health News:Triple Heart Valve Replacement Saves Local Women's Life at Portneuf Medical Center: Woman Gets a Second Chance at Life After Taking Fen-Phen 2Health News:ROBRADY Design's Work with Xhale Innovations Inc. Wins 2010 Medical Design Excellence Awards 2Health News:ROBRADY Design's Work with Xhale Innovations Inc. Wins 2010 Medical Design Excellence Awards 3Health News:Reducing Energy Consumption Dramatically: Green IT Conference Addresses Administration's Goals 2Health News:Intellicate Announces New &#8220;Phased Return to Work&#8221; (PRtW) Service 2Health News:Intellicate Announces New &#8220;Phased Return to Work&#8221; (PRtW) Service 3Health News:Sleep apnea tied to increased risk of stroke 2Health News:Sleep apnea tied to increased risk of stroke 3Health News:Sleep apnea tied to increased risk of stroke 4Health News:AthletiCo Offers Occupational Therapy Tips for Managing Arthritis 2Health News:AthletiCo Offers Occupational Therapy Tips for Managing Arthritis 3
(Date:1/14/2014)... , Jan. 14, 2014 InformEx, North America,s ... of high-value chemistry, will hold the 30 th edition ... Convention Center from January 21-24. (Logo: ... from top pharmaceutical, fine chemical and specialty chemical companies will ...
(Date:1/14/2014)... 14, 2014 Animal Emergency Critical Care, a LifeCentre partner practice, ... is the first in Loudoun County ... Dr. Susan M. Barnes , Medical Director, is a ... Dr. Cole Taylor , are avid scuba divers. "As altitude ...
(Date:1/14/2014)... , January 14, 2014 ... Transfer Devices (CSTD) for hazardous drugs, today announced that it ... fourth straight year.   Equashield,s closed ... technicians, pharmacists, nurses and other medical professionals who ...
Breaking Medicine Technology:Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Equashield's Sales Grow by 60% in 2013 2
... Calif., Dec. 7, 2011 Rigel Pharmaceuticals, Inc. (Nasdaq: ... the company,s president and chief operating officer, is scheduled ... Annual Healthcare Conference in New York City on Wednesday, ... (Logo: http://photos.prnewswire.com/prnh/20030226/RIGLLOGO ) To ...
... 7, 2011   Talyst has released an updated ... The bar code technology ensures virtually 100% of medications ... The improved AutoLabel is a complete ... and white transfer labels to improve patient safety at ...
Cached Medicine Technology:Talyst Updates Its AutoLabel® Solution 2
... INSTAT Collagen Absorbable Hemostat is a purified ... prepared as a sponge-like pad, is lightly ... which is an inherent property of collagen, ... structure of this protein. The helical structure ...
... Microspin centrifuge offers reliable microhematocrit determinations. Although ... it is more affordable than most competitive ... assures rapid spin-downs, and the included reader ... variety of circumstances. Offering quieter operation than ...
... international engineering and design specifications, Smith ... System* provides seamless integration with existing ... open reduction internal fixational procedures (AO ... well beyond the standard, providing a ...
... of the most technically demanding specialties within ... offers the highly specialized surgeon a complete ... the pelvis and acetabulum. , ,Joel ... pelvic surgeon, is the designer of this ...
Medicine Products: