Navigation Links
Experimental cancer pharmaceuticals under trial
Date:10/23/2007

A potent and selective inhibitor of the mitotic kinesin CENP-E (GSK923295A) demonstrates a novel mechanism of inhibiting tumor cell proliferation and shows activity against a broad panel of human tumor cell lines in vitro: Abstract A 111.

A first-in-class, targeted investigational therapy specifically designed to inhibit a single protein that functions only during cell division shows potent activity in a broad range of cancer cell lines, say researchers from GlaxoSmithKline. Because the compound is so specifically targeted, it may help reduce some of the more common toxic side effects of chemotherapy, they say.

The experimental drug, GSK923295A, inhibits the mitotic kinesin centromere-associated protein E (CENP-E), which is required during mitosis, the process by which a cell duplicates its genetic information in order to generate two, identical, daughter cells. The resulting mitotic arrest can lead to apoptosis, or cell death. A characteristic of CENP-E inhibition is the presence of misaligned or lagging chromosomes within cells attempting to replicate.

Investigators were able to observe lagging chromosomes in most tumor cells treated with GSK923295A. These effects are rarely observed in untreated cells, said the studys lead investigator, David Sutton, B.Sc., associate director of biology, within the Oncology division of GlaxoSmithKline in Collegeville, Pa. GlaxoSmithKline funded the study.

Although CENP-E is expressed in all dividing cells, GSK923925A is more likely to affect rapidly dividing cancer cells, Sutton says. Furthermore, because of the very low expression of CENP-E in non-dividing cells such as neurons, GSK923295A may not cause the peripheral nerve damage often seen with chemotherapy treatments such as taxanes and vinca alkaloids, which also inhibit mitosis, he says.

Studies conducted in animal models have shown complete tumor regression in some cancer types, says Sutton. In preclinical tests conduc
'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Experimental treatment for Ebola Virus Shows promising results in mice
2. FDA approves Phase 0 trial which tests experimental drugs on humans
3. Experimental drug to fight flu
4. Experimental SARS Vaccine
5. Experimental vaccine for shingles is effective
6. Experimental Blood Test May Spot Heart Attack Risk, Study Says
7. Five AIDS Patients To Receive Experimental Anti-retroviral Drugs
8. TMC 114 and 125 experimental drugs to be tested on four HIV patients
9. Protection against HIV and Herpes is possible with the Experimental Microbicide
10. Experimental Therapy Effective Against Malignant Melanoma in Horses
11. Experimental Alzheimer’s Drug curbs the disease in mic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... The New York Mobility Club (sponsored by ... about “ Sexuality & Intimacy ” for people with ... entertaining discussions are for mature audiences only. September 9 ... Mamaroneck, NY) and October 7 from 6-8 pm at ... The New York Mobility Club is a local community ...
(Date:8/27/2014)... Angeles, CA (PRWEB) August 27, 2014 ... to require a consumer to present personal information before ... changing the way that life insurance quotes are distributed ... , The term plans that an adult has ... provided by known U.S. companies. The system for quotation ...
(Date:8/27/2014)... Top 10 Best SEO Hosting, a well-known SEO Hosts Review ... iPage, Bluehost and GoDaddy are the most recommended suppliers for ... buy useful hosting (including VPS and cloud hosting). , ... has been serving hosting small business websites since 1998. With ... leader in the hosting industry for its affordable and easy ...
(Date:8/27/2014)... Recently, iFitDress.com, a professional company of ... designs of romantic bridal gowns . To top ... price (up to 66 percent off) when buying the ... line has been updated with these new items. All ... hopes that all clients can gain an enjoyable shopping ...
(Date:8/27/2014)... Skirt Sports , the innovative women’s running apparel brand ... Switzer, most noted for her brave running of the 1967 ... women’s running clothes that unites the history of women’s competitive ... , “It is such an honor to work ... is the original Skirt – she stood strong, pushing herself ...
Breaking Medicine News(10 mins):Health News:Bussani Mobility Sponsors New York Mobility Club Meetings September 9 & October 7 for People with Disabilities, Sexuality & Intimacy Discussed by Advocate Liz Treston 2Health News:Life Insurance Quotes for Term Policies Now Found at Insurer Website Online 2Health News:Well-known SEO Hosts Review Site Top10BestSEOHosting.com Recommends iPage, Bluehost and GoDaddy To Webmasters 2Health News:Promotion For Romantic Bridal Gowns Launched By Professional Company iFitDress.com 2Health News:Skirt Sports Launches Clothing Line with Legendary Runner Kathrine Switzer 2
... , , WARRENDALE, Pa., July ... to be showcased at the Premier healthcare alliance ... suppliers that are committed to improving patient outcomes through product innovation. ... one of only 24 products showcased at the event. , ...
... vitamin B deficiency , FRIDAY, July 17 (HealthDay ... surgery helps patients lose weight faster and avoid vitamin ... the "good" bacteria found in yogurt and in dietary ... of Medicine study included 44 patients who had Roux-en-Y ...
... Companies ... of dollars, says Reed Group President, Guidelines, Jon Seymour, MD. , ... Westminster, CO (Vocus) July 16, 2009 -- Companies whose ... dollars, says Reed Group President, Guidelines, Jon Seymour , MD. , , ...
... July 17 Dr. Gabriel DeCandido, a physician practicing internal medicine ... million to settle allegations that he defrauded the Medicare program, the ... In a complaint filed in the United States District Court ... Michael Flanery v. Dr. Gabriel DeCandido, et al ., the United ...
... , ELM GROVE, Wis., July 17 ... Percentile Rankings Within 4 Months is the second in ... a hospital process improvement firm. With federal funding at risk, ... helping avoid common mistakes made by hospitals when working on programs ...
... , SANTA MONICA, Calif., July 17 ... critical thinking, created the new website www.prescriptiondrugs.procon.org ... advertised directly to consumers?" , , ... published on whether direct to consumer (DTC) prescription drug ads ...
Cached Medicine News:Health News:MEDRAD Recognized by the Premier Healthcare Alliance for Commitment to Healthcare Quality Improvement and Innovation 2Health News:MEDRAD Recognized by the Premier Healthcare Alliance for Commitment to Healthcare Quality Improvement and Innovation 3Health News:MEDRAD Recognized by the Premier Healthcare Alliance for Commitment to Healthcare Quality Improvement and Innovation 4Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 2Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 3Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 4Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 5Health News:Tampa Bay Doctor Agrees to Pay United States $1.7 Million to Resolve Medicare Fraud Allegations 2Health News:Compirion Healthcare Sponsors Webinar on 7 Mistakes That Lower Patient Satisfaction Scores 2Health News:Compirion Healthcare Sponsors Webinar on 7 Mistakes That Lower Patient Satisfaction Scores 3Health News:Debate Over Advertising Prescription Drugs to Consumers Goes Online at New ProCon.org Website 2
(Date:8/27/2014)... YORK , Aug. 27, 2014 ... new market research report is available ... Chinese Guidebook for Application and Approval ... Regulations to Practices (2014 Edition) ... Now, Chinese regulations ...
(Date:8/27/2014)... 27, 2014  CVS Caremark (NYSE: CVS ... clinical affiliation with MedStar Health, a leading health care ... and the Washington, DC , ... care services for patients. Through this clinical affiliation, MedStar ... support, medication counseling, chronic disease monitoring and wellness programs ...
(Date:8/27/2014)... Amgen (NASDAQ: AMGN ) today ... granted priority review designation for ivabradine for the treatment ... drug that inhibits the I f ... cardiac pacemaker. 1 Ivabradine works to slow the ... ventricular repolarization. 1 Heart failure is a common ...
Breaking Medicine Technology:Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 2Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 3Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 4Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 5Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 6Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 7Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 8Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 9Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 10CVS Caremark Announces New Clinical Affiliation with MedStar Health 2CVS Caremark Announces New Clinical Affiliation with MedStar Health 3FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 2FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 3FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 4FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 5FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 6FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 7
... Federal, state and local dignitaries ushered in a ... with the dedication of a laboratory complex designed to ... The complex, housing 78 labs and other facilities, ... combining scientists from different fields and allowing them to ...
... Md., Oct 21, 2011 /PRNewswire-iReach/ -- ... accreditation for their Maryland Campus from the Accrediting Bureau ... meeting. ABHES is recognized by the United ... postsecondary institutions in the United States offering predominantly allied ...
Cached Medicine Technology:MUSC Dedicates New Bioengineering and Drug Discovery Hubs 2Institute of Health Sciences Receives ABHES Institutional Accreditation for Long Distance Education 2
... Esteem™ External Vacuum Therapy System restores sexual ... men. Non-invasive and low cost vacuum therapy, ... desirable outcome", makes it the ideal therapy ... Therapy System causes penile rigidity that can ...
Easy to Use manual vacuum system features a pumping mechanism that can be operated with one hand....
... D.O.R.C. Associate is an advanced ophthalmic ... and Venturi pump, allowing surgeons to ... Phaco or Vitrectomy procedures.,The key feature ... microprocessor-controlled vacuum system that measures in-line ...
... D.O.R.C. Harmony Total TTC® is a complete ... vitreoretinal surgery. Color coded function modes with ... compact design assures an easy to operate ... linear function footswitch provides the surgeon complete ...
Medicine Products: