Navigation Links
Experimental antibody shows early promise for treatment of childhood tumor
Date:5/8/2014

Tumors shrank or disappeared and disease progression was temporarily halted in 15 children with advanced neuroblastoma enrolled in a safety study of an experimental antibody produced at St. Jude Children's Research Hospital. Four patients are still alive after more than two-and-a-half years and without additional treatment.

Findings from the Phase I study were published recently online and will appear in the May 10 edition of the Journal of Clinical Oncology. The results prompted St. Jude to expand clinical trials of the monoclonal antibody hu14.18K322A to include patients newly diagnosed with neuroblastoma. Monoclonal antibodies are engineered in the laboratory to recognize and attach to specific markers carried on the cell surface.

Neuroblastoma is a cancer of the sympathetic nervous system. It is the most common cancer diagnosed in the first year of life and accounts for 7 to 10 percent of childhood cancers. While certain patients, particularly infants, enjoy cure rates of 90 percent or better, the outlook is worse for high-risk patients, including those whose disease has spread widely. New treatments are urgently needed for these patients, less than half of whom currently enjoy long-term, disease-free survival.

"This was the first time this experimental antibody was tried in patients. We were encouraged with the response," said first and corresponding author Fariba Navid, M.D., an associate member of the St. Jude Department of Oncology. "The percentage of patients who benefited from treatment with hu14.18K322A was unusual for a Phase I study."

Phase I studies focus on questions related to the safety and best dose of experimental therapies. The research involves patient volunteers whose cancer has returned or did not respond to standard treatment, which for neuroblastoma includes surgery, chemotherapy, radiation and bone marrow transplants.

In this study, 38 St. Jude patients received one of nine different
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Experimental drug prolongs life span in mice
2. Experimental drug shows promise for treatment-resistant leukemias
3. Diabetes drug shows promise in reducing Alzheimers disease in an experimental model
4. Experimental drug could enhance multiple myeloma and myeloid leukemia therapies
5. Experimental drug shows encouraging results in treating most common form of lung cancer
6. Studies of experimental hepatitis C drug show promise for preventing recurrence in liver transplant
7. ASSURE study of experimental agent to raise HDL yields disappointing and surprising results
8. York physicists offer novel insight into experimental cancer treatment
9. Experimental Drug Shows Benefits Against Melanoma in Early Study
10. Experimental Drugs Show Promise Against Prostate Cancer
11. Experimental Drug Seems to Aid Memory in Mice With Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... A new study of self-awareness by Kessler ... (MS) may be able to improve their self-awareness ... ahead of print on July 2 in ... Nancy D. Chiaravalloti & John DeLuca: Metacognitive knowledge ... doi: 10.3233/NRE-141113). Self-awareness is one,s ability to recognize ...
(Date:8/22/2014)... Newport Hospital has again attained the distinguished ... Center,s (ANCC) Magnet Recognition Program. Considered the gold ... program recognizes nursing excellence and professionalism. It is ... The unanimous decision to redesignate Newport Hospital was ... national standards of nursing practice. , "It is ...
(Date:8/22/2014)... -- Counseling may do little to help young people ... analyzed 66 studies that included nearly 18,000 people 25 ... for drinking problems. Participants in 49 studies attended a ... of the studies attended group sessions or a mix ... called motivational interviewing was used in the studies. This ...
(Date:8/22/2014)... breakthrough treatments have become available for key subtypes ... these treatments can be pre-identified by looking for ... patients whose lung cancer is driven by rearrangement ... the drug crizotinib, which targets this abnormality. Many ... this success by matching different drugs with specific ...
(Date:8/22/2014)... ItsHot.com, a client-centric manufacturer, wholesaler and ... on its range of beautiful diamond heart pendants. Customers ... Hearts 14K White Rose Gold Diamond Heart Pendant, which ... 77%. Previously priced at $3,715.00, customers can now buy ... of this mesmerizing pendant embedded with 0.66 carats round ...
Breaking Medicine News(10 mins):Health News:Kessler Foundation study of self-awareness in MS has implications for rehabilitation 2Health News:Newport Hospital receives nursing's highest credential for third time with Magnet recognition 2Health News:Counseling Does Little to Deter Youth Drinking, Review Finds 2Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 2Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 3Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 4Health News:ItsHot.com Now Offers 60-80% Discount on its Striking Collection of Diamond Heart Pendants 2
... BRIGHTON, Mich., June 30 LifeSecure Insurance Company,(LifeSecure), ... of,Michigan, today announced the executive appointment of Ron ... an accomplished sales executive with extensive knowledge of,the ... LifeSecure, he was,regional sales vice president, long term ...
... Mesothelioma Center as a way for victims, or the ... get help,very honest advice & tailor made assistance at ... According to Americas Watchdog, "watching what happened to a ... help all Mesothelioma victims, with the best possible free ...
... to reduce pain in newborns undergoing painful procedures ... (venipuncture) for the newborn screening test but not ... co-authors. , In this double-blind, randomized controlled ... Hospital, researchers found that "sucrose reduced overall pain ...
... and US guidelines on how much physical activity children need to ... conclude researchers in a study published ahead of print in the ... than half of boys and only one in eight girls manage ... the long term monitoring of 113 boys and 99 girls from ...
... strategies humans use to regulate emotions can determine both ... of New York University and Rutgers University neuroscientists has ... of the journal Nature Neuroscience , shed light ... making. , Previous research has demonstrated these strategies ...
... a revolutionary day in history for anybody who cares about Lung Cancer, ... July 4th, Independence Day, for Lung Cancer. For the first time, in ... Senators Chuck Hagel, Dianne Feinstein and the tireless work over the last ... , ...
Cached Medicine News:Health News:The Mesothelioma Victims Center Offers Victims Of Asbestos Related Cancer & Their Loved Ones The Most Comprehensive Free Service Especially For US Navy Veterans 2Health News:The Mesothelioma Victims Center Offers Victims Of Asbestos Related Cancer & Their Loved Ones The Most Comprehensive Free Service Especially For US Navy Veterans 3Health News:UK and US guidelines on kids' physical activity levels need rethinking 2Health News:NYU, Rutgers study shows how using mental strategies can alter the brain's reward circuitry 2Health News:Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter 2Health News:Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter 3Health News:Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter 4
(Date:8/22/2014)... MC Medical, a subsidiary of Mitsubishi Corporation (MCM), and Minimally ... medical device company, have formally agreed to an exclusive ... in Japan . It is anticipated that ... in the latter half of 2015. ... in endoscopic surgery market in Japan . ...
(Date:8/22/2014)... , Aug. 22, 2014  Mark Riccio, ... (CT) imaging facility, is using the online crowd-funding ... even 5D imaging to researchers and would-be superheros ... asks "What would YOU do if you had ... to researchers and explorers everywhere, from elementary through ...
(Date:8/22/2014)... 22, 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) today ... units of common stock and warrants at a price ... million, prior to deducting underwriting discounts and commissions and ... warrants are immediately separable and will be issued separately.  ... trading on The NASDAQ Stock Market under the ticker ...
Breaking Medicine Technology:MC Medical agrees to be the exclusive distributor of FloShield products in Japan 2Cornell's X-ray Imaging Lab Director Uses Kickstarter Campaign to "Democratize" Advanced 3D Imaging 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4
Straight shafts with heavy Elschnig teeth. Flat serrated handle with slide style lock and polished finished....
Straight shafts with fine Pierse type tips. Flat smooth handle with dull finish....
Straight shafts with delicate 0.7 mm, 1 x 2 teeth. Serrated handle with polished finish....
Straight shafts with 1 x 2 Elsching style teeth. Wide serrated handle with polished finish....
Medicine Products: