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Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
Date:8/30/2007

ple myeloma, a cancer of the white blood cells in bone marrow.

What excites me is that we have taken things we learned about Hedgehog signaling in these relatively rare childhood brain tumors and translated them into an even more aggressive adult tumor, Eberhart said.

More than 10,000 Americans die annually from glioblastomas. Radiation is the standard therapy for the disease, and several years ago, the U.S. Food and Drug Administration approved adding the drug temozolomide to radiotherapy because the combination provided a small survival increase.

This is an incredibly difficult tumor to treat, says first author Eli E. Bar, Ph.D., a postdoctoral fellow. Survival for glioblastoma has not changed much in 30 years. With the addition of temozolomide, survival got bumped from 12 months to 14 or 15 months.


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Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

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