Navigation Links
Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
Date:8/30/2007

A drug that shuts down a critical cell-signaling pathway in the most common and aggressive type of adult brain cancer successfully kills cancer stem cells thought to fuel tumor growth and help cancers evade drug and radiation therapy, a Johns Hopkins study shows.

In a series of laboratory and animal experiments, Johns Hopkins scientists blocked the signaling system, known as Hedgehog, with an experimental compound called cyclopamine to explore the blockades effect on cancer stem cells that populate glioblastoma multiforme. Cyclopamine has long been known to inhibit Hedgehog signaling.

They reported their findings in the journal Stem Cells published online on July 19.

Our study lends evidence to the idea that the lack of effective therapies for glioblastoma may be due to the survival of a rare population of cancer stem cells that appear immune to conventional radiation and chemotherapy, says Charles G. Eberhart, M.D., Ph.D., associate professor of pathology, ophthalmology and oncology, who led the work. Hedgehog inhibition kills these cancer stem cells and prevents cancer from growing and may thus develop into the first stem cell-directed therapy for glioblastoma.

Eberhart cautioned that while his study appears to prove the principle of Hedgehog blocking, much work remains before cyclopamine or any similar drug can be tested in patients. Scientists must determine whether the drug can be effectively and safely delivered to the whole body or whether it must go into the brain, and what if any adverse impact on normal stem cells the treatment might cause.

Once youve answered those questions in animals, the next step would be starting phase I clinical trials in humans, Eberhart said.

The new study adds to the growing evidence that only a small percentage of cancer cells - in this case stem cells - are capable of unlimited self-renewal and that these cells alone power a tumors growth.

Eberhart focused
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related medicine news :

1. Experimental treatment for Ebola Virus Shows promising results in mice
2. Experimental drug to fight flu
3. Experimental SARS Vaccine
4. Experimental vaccine for shingles is effective
5. Experimental Blood Test May Spot Heart Attack Risk, Study Says
6. Five AIDS Patients To Receive Experimental Anti-retroviral Drugs
7. TMC 114 and 125 experimental drugs to be tested on four HIV patients
8. FDA approves Phase 0 trial which tests experimental drugs on humans
9. Protection against HIV and Herpes is possible with the Experimental Microbicide
10. Experimental Therapy Effective Against Malignant Melanoma in Horses
11. Experimental Alzheimer’s Drug curbs the disease in mic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... 2013 BroadConnect Telecom, the nation’s ... and IT security solutions, present small to midsized ... by more than fifty percent (when compared to ... PBX Bundle Pricing. BroadConnect’s hosted Voice solutions are ... VoIP. , Starting today, until the end of ...
(Date:5/24/2013)... 24, 2013 With today’s levels of weight ... for advice on the causes of weight gain and how ... that suggest causes of weight gain and treatments that will ... was released by the Child Study Center at NYU ... childhood diagnosis of ADHD and the soring rates of obesity ...
(Date:5/24/2013)... Wednesday, 15th May 2013 | 10am BST | ... webinar playback: http://bit.ly/10Rt0ZH , Ongoing regulatory changes are ... the globe and particularly in Europe, a number of these ... . For dealmakers, understanding how the likes of Basel iii, ... your corner of the market will give you a competitive ...
(Date:5/24/2013)... IMED Mobility, a premier provider of wheelchair vans ... Michelle Murray on Thursday, June 20th 2 p.m to 5 p.m. ... and movie tour, which shares the story of Sam Schmidt, an ... in 2000. Much of the film takes place on the racetrack, ... INDYCAR racing despite suffering a crash that left him paralyzed. In ...
(Date:5/23/2013)... Sublime Beauty® is introducing its ... line, with a 35% discount through May 31st. ... proprietary products, the Cellulite Whisperer® Gel ... receive a report "Getting Control of Your Cellulite" ... wonderful grapefruit scent," says Kathy Heshelow, founder of ...
Breaking Medicine News(10 mins):Health News:BroadConnect Is Offering New Hosted PBX Bundle Pricing for New Customers, Eliminating VoIP Adoption Barriers 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Now Help Patients with Weight Gain Linked to Childhood ADHD Lose Weight Fast 2Health News:Register to Access Webinar Playback - The Impact of Financial Regulation on M&A in 2013 2Health News:Register to Access Webinar Playback - The Impact of Financial Regulation on M&A in 2013 3Health News:Local Mobility Dealer Hosts Nashville Recording Artist 2Health News:Fresh Organics in the New Cellulite Whisperer® Products from Sublime Beauty®; "Get Ready for Summer Sale" Continues 2
... WINNIPEG, June 30 /PRNewswire/ - Winnipeg-based medical device ... the 21st Century Achievement Award during the Computerworld ... in Washington D.C. IH Systems received the award ... Automation), the world,s first solution combining software, robotics ...
... 30 The Renal Physicians Association (RPA) supports Kidney ... in Kidney Care (PEAK) initiative. RPA is a member ... dialysis providers, physicians, manufacturers, and nurses who work together ... The goal of the PEAK campaign is to reduce ...
... that chronic disease in either a mother or father ... associated with the development of polycystic ovarian syndrome (PCOS) ... of women with PCOS and insulin resistance are themselves ... suggesting that factors associated with the condition can be ...
... have a diminished number of eggs in their ovaries, either ... as ovarian surgery, may be more at risk of a ... normal, fertile range. Trisomic pregnancies occur when the embryo ... two. The most common trisomy is Down,s syndrome or trisomy ...
... 2009 Elsevier, the leading publisher of scientific, technical ... publishing partnership with The European Association for the Study ... leading European association in the field of liver research. ... flagship journal, the Journal of Hepatology ( ...
... Calif., June 30 Endologix, Inc. (Nasdaq: ELGX ... announced that it has been added to the Russell 3000(R), ... after the close of the U.S. markets. , , ... Endologix is now included in the Russell Indexes, which has ...
Cached Medicine News:Health News:Intelligent Hospital Systems Receives International Award for Innovative Technology Benefiting Society 2Health News:Polycystic ovarian syndrome: New light on its causes and its effect on brothers 2Health News:Polycystic ovarian syndrome: New light on its causes and its effect on brothers 3Health News:Polycystic ovarian syndrome: New light on its causes and its effect on brothers 4Health News:Reduced ovarian reserve associated with increased risk of trisomic pregnancy 2Health News:Reduced ovarian reserve associated with increased risk of trisomic pregnancy 3Health News:Endologix Added to Russell Indexes 2
(Date:5/23/2013)... , May 23, 2013 Hearing health affects a ... younger, and remain socially and professionally engaged, he should address ... overriding message that the Better Hearing Institute (BHI) ... National Men,s Health Week , which leads up to ... runs from June 10 through June 16. ...
(Date:5/23/2013)...  A recently published clinical study conducted at TOPS ... , demonstrates that 3D mammography (breast tomosynthesis) significantly reduces ... The study, "Implementation of Breast Tomosynthesis in a ... Stephen L. Rose , MD, and ... Journal of Roentgenology (AJR). The AJR is the ...
(Date:5/23/2013)... 2013  Hadasit Bio-Holdings Ltd. (TASE: HDST, OTC: ... based on intellectual property developed and owned by ... foremost medical research center, today announced that its ... funding from the Israeli Ministry of Industry and ... support product development and advance clinical trials. Cell ...
Breaking Medicine Technology:Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 2Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 3Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 4First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 2First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 3Hadasit Bio-Holdings Ltd. Portfolio Company - Cell Cure Neurosciences Ltd. Received Additional Government Support 2
... -- Phase II,results exceed expectations - Alchemia prepares ... company Alchemia Limited will,commence discussions with the US ... of the Phase II clinical trial,of its metastatic ... from the randomized Phase II clinical trial in ...
... data on Eloxatin(R), Taxotere(R) and on three investigational,agents ... at the 43rd,annual ASCO meeting, BRIDGEWATER, N.J., May ... total of 375 abstracts,indicative of its oncology commitment ... the American Society of Clinical Oncology,(ASCO) in Chicago, ...
Cached Medicine Technology:Positive Final Data from HyCAMP Phase II Trial in Metastatic,Colorectal 2Positive Final Data from HyCAMP Phase II Trial in Metastatic,Colorectal 3Positive Final Data from HyCAMP Phase II Trial in Metastatic,Colorectal 4Data to be Presented at ASCO 2007 Highlights sanofi-aventis,Commitment to Cancer Care and Research 2Data to be Presented at ASCO 2007 Highlights sanofi-aventis,Commitment to Cancer Care and Research 3Data to be Presented at ASCO 2007 Highlights sanofi-aventis,Commitment to Cancer Care and Research 4Data to be Presented at ASCO 2007 Highlights sanofi-aventis,Commitment to Cancer Care and Research 5Data to be Presented at ASCO 2007 Highlights sanofi-aventis,Commitment to Cancer Care and Research 6Data to be Presented at ASCO 2007 Highlights sanofi-aventis,Commitment to Cancer Care and Research 7Data to be Presented at ASCO 2007 Highlights sanofi-aventis,Commitment to Cancer Care and Research 8Data to be Presented at ASCO 2007 Highlights sanofi-aventis,Commitment to Cancer Care and Research 9Data to be Presented at ASCO 2007 Highlights sanofi-aventis,Commitment to Cancer Care and Research 10Data to be Presented at ASCO 2007 Highlights sanofi-aventis,Commitment to Cancer Care and Research 11Data to be Presented at ASCO 2007 Highlights sanofi-aventis,Commitment to Cancer Care and Research 12
... Multifunctional instrumentation, capable of comminution, ... by means of ultra-sonic energy. ... organs, and, in particular, parenchymatous ... of tissue-selection and non-traumatic preparation ...
... system is the recognized world leader, ... superior tactile feedback and exceptional visualization ... surgical modality combines tissue fragmentation, irrigation, ... performance in procedures requiring precise, selective ...
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Deflected large type, opening width 7.0 mm and length 7.5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Deflected large type, opening width 8.0 mm and length 7.5 mm....
Medicine Products: