Navigation Links
Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
Date:8/30/2007

A drug that shuts down a critical cell-signaling pathway in the most common and aggressive type of adult brain cancer successfully kills cancer stem cells thought to fuel tumor growth and help cancers evade drug and radiation therapy, a Johns Hopkins study shows.

In a series of laboratory and animal experiments, Johns Hopkins scientists blocked the signaling system, known as Hedgehog, with an experimental compound called cyclopamine to explore the blockades effect on cancer stem cells that populate glioblastoma multiforme. Cyclopamine has long been known to inhibit Hedgehog signaling.

They reported their findings in the journal Stem Cells published online on July 19.

Our study lends evidence to the idea that the lack of effective therapies for glioblastoma may be due to the survival of a rare population of cancer stem cells that appear immune to conventional radiation and chemotherapy, says Charles G. Eberhart, M.D., Ph.D., associate professor of pathology, ophthalmology and oncology, who led the work. Hedgehog inhibition kills these cancer stem cells and prevents cancer from growing and may thus develop into the first stem cell-directed therapy for glioblastoma.

Eberhart cautioned that while his study appears to prove the principle of Hedgehog blocking, much work remains before cyclopamine or any similar drug can be tested in patients. Scientists must determine whether the drug can be effectively and safely delivered to the whole body or whether it must go into the brain, and what if any adverse impact on normal stem cells the treatment might cause.

Once youve answered those questions in animals, the next step would be starting phase I clinical trials in humans, Eberhart said.

The new study adds to the growing evidence that only a small percentage of cancer cells - in this case stem cells - are capable of unlimited self-renewal and that these cells alone power a tumors growth.

Eberhart focused
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Experimental treatment for Ebola Virus Shows promising results in mice
2. Experimental drug to fight flu
3. Experimental SARS Vaccine
4. Experimental vaccine for shingles is effective
5. Experimental Blood Test May Spot Heart Attack Risk, Study Says
6. Five AIDS Patients To Receive Experimental Anti-retroviral Drugs
7. TMC 114 and 125 experimental drugs to be tested on four HIV patients
8. FDA approves Phase 0 trial which tests experimental drugs on humans
9. Protection against HIV and Herpes is possible with the Experimental Microbicide
10. Experimental Therapy Effective Against Malignant Melanoma in Horses
11. Experimental Alzheimer’s Drug curbs the disease in mic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... For the fifth year in a row, ... observing September 26th as Mesothelioma Awareness Day, by attending ... , Members of the community who wish to ... will be providing t-shirts and signs to participating community ... have received attention from Al Roker and ...
(Date:8/29/2014)... Empty Nest Syndrome on Dr. Carol ... , Mothers and fathers, who dedicated the last ... laughing and sweating through parenting, launch their college ... Relief and parenting pride intermix with loss, depression ... Carol Francis as a Clinical Psychologist has helped ...
(Date:8/29/2014)... PreDiabetes Centers , the country’s leading prediabetes ... Web shoppers a 20% discount off orders of $100 or ... healthy living shop, beginning September 1. , Keeping your ... into the chilly fall season. , Autumn’s cooler, cozier weather ... usually ditch the healthy salads and opt for creamy soups, ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 TayganPoint Consulting ... that for the second time, Inc. Magazine has named ... in America. , Based on solid revenue growth of ... No. 2341 overall on the list. TayganPoint’s repeat ... environment of the past few years, is a demonstration ...
(Date:8/29/2014)... 2014 Innovations Television, produced by DMG Productions, ... of Innovations, focusing on health and elderly care, slated to ... number of Americans over 65 will nearly double by 2030, ... in 2030, for a total of 72 million people. Though ... have at least one chronic condition and use healthcare services ...
Breaking Medicine News(10 mins):Health News:Organization to Raise Awareness of Mesothelioma on the Today Show 2Health News:Psychologist Dr. Carol Francis Addressing Empty-Nest Syndrome on Talk Radio Today 2Health News:Psychologist Dr. Carol Francis Addressing Empty-Nest Syndrome on Talk Radio Today 3Health News:PreDiabetes Centers Online Store Launches Fall Savings Event 2Health News:Innovations with Ed Begley, Jr., Seeking Content for Upcoming Series on Health and Elder Care 2
... new asthma inhaler revealed that it has problems. This investigation was ... the funding for Ventolin inhalers in favour of Salamol. ... Only 15 of them were able to stick to the study. ... or due to the taste. Asthma stability had deteriorated in 93% ...
... According to researchers, a gene determines people’s sensitivity to ... chronic pain could be prevented by blocking the expression ... inflammation. This could be a breakthrough in development of ... about a quarter of them had the genetic variant ...
... be dangerous as the tablet’s special coating controls the release ... serious side effects. ,David Wright, who led a ... take drugs in patch, liquid or inhaler form.”,Difficulty in swallowing ... Studies have revealed that tablets are being crushed and given ...
... interesting study conducted at National University of Singapore recently ... November 1, 2006 edition, to study the tangible benefits ... discovered that a regular consumption of meals which are ... degenerative processes of the brain which is often indelibly ...
... Butler, a pioneering plastic and reconstructive surgeon has been ... ethics committee of the Royal Free Hospital, London to ... ,However the Royal College of Surgeons has called for ... transplantation. ,The surgery promises to transform the lives ...
... a new drug for treatment of obesity, has been found to ... with diabetes type 2. The research was done on 1,047 overweight ... and North America. ,Some of them were given 5 or ... a placebo, for a 1 year period. Those on the drug ...
Cached Medicine News:Health News:Gene determines pain threshold... 2Health News:Spices in curries spruce up aging minds 2Health News:Green Signal given to Full-Face Transplants 2Health News:Green Signal given to Full-Face Transplants 3
(Date:8/28/2014)... Mass. , Aug. 28, 2014  Decision ... system market will grow strongly through 2022 at ... percent. This will be largely supported by strong ... will increase demand for imaging procedures. The Indian ... allow more facilities to purchase or upgrade diagnostic ...
(Date:8/28/2014)... /PRNewswire-iReach/ -- CountryFocus: Healthcare, Regulatory and Reimbursement Landscape ... (Photo - http://photos.prnewswire.com/prnh/20140828/140879 ) ... Landscape Poland " an essential source of information ... market and provides insights into the demographic, regulatory, ... report provides valuable insights into the trends and ...
(Date:8/28/2014)... Japan , Aug. 28, 2014 ... of the post-marketing commitment and submissions of data ... including the United States ... Medicines Agency (EMA) and the Japanese Ministry of ... Pharmaceuticals and Medical Devices Agency (PMDA) for pioglitazone ...
Breaking Medicine Technology:Indian Diagnostic Imaging System Market Will Grow at 6 Percent Annually Through 2022 2Indian Diagnostic Imaging System Market Will Grow at 6 Percent Annually Through 2022 3Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 2Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 3Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 4Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 5Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 2Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 3Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 4Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 5Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 6
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: