Navigation Links
Experimental agent briefly eases depression rapidly in test
Date:12/12/2012

A drug that works through the same brain mechanism as the fast-acting antidepressant ketamine briefly improved treatment-resistant patients' depression symptoms in minutes, with minimal untoward side effects, in a clinical trial conducted by the National Institutes of Health. The experimental agent, called AZD6765, acts through the brain's glutamate chemical messenger system.

Existing antidepressants available through prescription, which work through the brain's serotonin system, take a few weeks to work, imperiling severely depressed patients, who can be at high risk for suicide. Ketamine also works in hours, but its usefulness is limited by its potential for dissociative side-effects, including hallucinations. It is being studied mostly for clues to how it works.

"Our findings serve as a proof of concept that we can tap into an important component of the glutamate pathway to develop a new generation of safe, rapid-acting practical treatments for depression," said Carlos Zarate, M.D., of the NIH's National Institute of Mental Health, which conducted the research.

Zarate, and colleagues, reported on their results online Dec. 1, 2012 in the journal Biological Psychiatry.

AZD6765, like ketamine, works by blocking glutamate binding to a protein on the surface of neurons, called the NMDA receptor. It is a less powerful blocker of the NMDA receptor, which may be a reason why it is better tolerated than ketamine.

About 32 percent of 22 treatment-resistant depressed patients infused with ASD6765 showed a clinically meaningful antidepressant response at 80 minutes after infusion that lasted for about half an hour with residual antidepressant effects lasting two days for some. By contrast, 52 percent of patients receiving ketamine show a comparable response, with effects still detectable at seven days. So a single infusion of ketamine produces more robust and sustained improvement, but most patients continue to
'/>"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH-funded trial launched to assess experimental TB drug
2. Experimental graft-vs.-host disease treatment equivalent to standard care in Phase 3 trial
3. Experimental Antidepressant Appears Quick-Acting, Safe
4. More than a third of high-risk leukemia patients respond to an experimental new drug
5. Updated Clinical Results Show Experimental Agent Ibrutinib as Highly Active in CLL Patients
6. Experimental Insomnia Drug Shows Promise
7. Experimental Dengue Vaccine Shows Some Success
8. Standard chemotherapy provides higher survival rate than experimental in lung cancer patients
9. Cancer turns off important immune cells, complicating experimental vaccine therapies
10. Experimental Drug May Cut Severe Asthma Attacks: Study
11. Experimental Drug Suppresses Appetite in Mice: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 21, 2014 Local agencies in the ... discounts for specific protection plans, according to released insurer ... to quote life insurance from local agencies using its ... agents that appear inside of the national system are ... of price reviews this year. Adults who enter the ...
(Date:8/21/2014)... August 22, 2014 Recently, Skmen.com, a distinguished ... selection of girls’ casual dresses . From today ... (up to 30 percent off) when they are shopping at ... new casual outfits are according to the newest quality standards; ... to the charming casual dresses, worldwide ladies can also access ...
(Date:8/21/2014)... 2014 August 11: – Robin William’s ... life by hanging, likely due to long-term depression. ... foremost BioAcoustic Vocal Profiling investigator, appeared on the Joyce ... Williams’ death; hoping to help people understand why he ... Williams’ suicide were proposed in terms of BioAcoustic Biology: ...
(Date:8/21/2014)... Recently, iFitDress.com, a famous online supplier of wedding dresses and ... new range of plus size evening dresses for 2014 ... all these fashionable gowns are available at discounted rates, up ... “We are very proud to unveil the new plus size ... variety of fashionable outfits at affordable rates. They are all ...
(Date:8/21/2014)... The “Proteomics Market by Technology (Protein Microarray, Mass ... X-ray Crystallography) - Instruments, Reagents & Services - ... major market drivers, restraints, and opportunities in North ... World (RoW) , Browse 138 market data tables, ... TOC on “Proteomics Market by Technology (Protein Microarray, ...
Breaking Medicine News(10 mins):Health News:Life Insurance from Local Agents Now Priced Nationally Through Complimentary Tool Online 2Health News:Charming Girls’ Casual Dresses Now Released by Distinguished Garment Company Skmen.com 2Health News:Robin Williams: What he could not bear to face 2Health News:Robin Williams: What he could not bear to face 3Health News:iFitDress.com: Cheap Plus Size Evening Dresses for 2014 Now Available 2Health News:Proteomics Market worth $20,696.4 Million by 2018 - New Research Report by MarketsandMarkets 2Health News:Proteomics Market worth $20,696.4 Million by 2018 - New Research Report by MarketsandMarkets 3Health News:Proteomics Market worth $20,696.4 Million by 2018 - New Research Report by MarketsandMarkets 4Health News:Proteomics Market worth $20,696.4 Million by 2018 - New Research Report by MarketsandMarkets 5
... of acres of farmland affected by last October,s red mud ... threat to a bountiful harvest, not toxic metals. In a ... also describe an inexpensive decontamination strategy using the mineral gypsum, ... note that a dam burst at a factory processing aluminum ...
... espionage agents probing an enemy,s fortifications, scientists are snooping ... that plants use to protect themselves from diseases. The ... natural defenses and enhance the safety and security of ... an article in the current edition of Chemical & ...
... Teenage girls and young women infected with HIV get pregnant ... HIV-negative peers, according to new research led by Johns Hopkins ... on an analysis of records from 181 patients with HIV, ... years, will be published in the Feb. 2 issue of ...
... keep hospital patients safe and continually improve the overall ... figure out a way to get physicians more involved ... patient care make their contributions to improvement efforts essential," ... patient safety expert and co-author of a commentary published ...
... Figures from a recently compiled report for 2009-2010 show ... students made a $6.8 million economic impact in the ... Education Centers. Specifically, AHEC faculty from UofL provided ... a total of $124,363 in living and travel expenses ...
... A targeted delivery combination selectively crosses the tight barrier that ... and bind to brain tumors, a research team led by ... reported in the January issue of the Journal of ... demonstrated that the targeted particles guide payloads to image tumors, ...
Cached Medicine News:Health News:Teens with HIV at high risk for pregnancy, complications 2Health News:More doctors must join nurses, administrators in leading efforts to improve patient safety, outcomes 2Health News:UofL Area Health Education Centers' faculty, students make $6.8 million economic impact 2Health News:UofL Area Health Education Centers' faculty, students make $6.8 million economic impact 3Health News:Targeted particle fools brain's guardian to reach tumors 2Health News:Targeted particle fools brain's guardian to reach tumors 3Health News:Targeted particle fools brain's guardian to reach tumors 4
(Date:8/21/2014)... , Aug. 21, 2014  Aptuit LLC ... West Lafayette, Indiana , has enhanced its ... characterization of small and large molecules, including biologic ... the Bruker maXisPlus Q-TOF mass spectrometer. ... , CEO, Aptuit, said, "The expanded large molecule ...
(Date:8/21/2014)... Aug. 21, 2014   Memorial Hermann Health System ... today announced a new partnership to provide a new ... breast care centers in the greater Houston ... will become the exclusive provider of professional breast radiology services ... in Memorial City, The Woodlands , Northeast, ...
(Date:8/21/2014)... , Aug. 21, 2014  Vermillion, Inc. (NASDAQ: ... gynecologic cancers and women,s health, has appointed Holly ... Managed Markets. Ms. Bauzon has a proven ... payer coverage for laboratory services companies. She has more ... PerkinElmer, Inc., where she held the position of Director, ...
Breaking Medicine Technology:Aptuit SSCI Adds Ultra High Resolution Q-TOF Mass Spectrometer for Large & Small Molecule Analyses 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2
... I Results Offer Hope of First Highly Effective Drug in ... June 1 Roche announced today results from a Phase ... promising treatment for patients with advanced melanoma whose cancer harbours ... PLX4032 lived for a median of at least six months ...
... Eli Lilly and Company announced today that Phase ... (gemcitabine HCl for injection) to the current standard of ... at three years for women with locally advanced cervical ... commonly diagnosed women,s cancer, and the second most common ...
Cached Medicine Technology:Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer 2Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer 3Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer 4Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer 5Study Showed Lilly's GEMZAR(R) (gemcitabine HCl for injection) Improved Progression-Free Survival in Cervical Cancer Patients 2Study Showed Lilly's GEMZAR(R) (gemcitabine HCl for injection) Improved Progression-Free Survival in Cervical Cancer Patients 3Study Showed Lilly's GEMZAR(R) (gemcitabine HCl for injection) Improved Progression-Free Survival in Cervical Cancer Patients 4Study Showed Lilly's GEMZAR(R) (gemcitabine HCl for injection) Improved Progression-Free Survival in Cervical Cancer Patients 5Study Showed Lilly's GEMZAR(R) (gemcitabine HCl for injection) Improved Progression-Free Survival in Cervical Cancer Patients 6
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: