Navigation Links
Experimental Vaccine Seems to Stop Nicotine Addiction in Mice

WEDNESDAY, June 27 (HealthDay News) -- A vaccine could someday help smokers kick the habit once and for all, according to a study that found the shot successfully treated nicotine addiction in mice in just one dose.

Although the findings hold promise, experts note that research involving animals frequently fails to lead to benefits for humans. In addition, the vaccine must be tested in rats and then primates before it can be tested in humans.

The researchers who developed the vaccine, however, say it could be the strategy that finally helps millions of smokers quit.

"While we have only tested mice to date, we are very hopeful that this kind of vaccine strategy can finally help the millions of smokers who have tried to stop, exhausting all the methods on the market today but finding their nicotine addiction to be strong enough to overcome these current approaches," the study's lead investigator, Dr. Ronald Crystal, chairman and professor of genetic medicine at Weill Cornell Medical College in New York City, said in a news release.

"Smoking affects a huge number of people worldwide, and there are many people who would like to quit but need effective help," he added. "This novel vaccine may offer a much-needed solution."

The vaccine works by preventing nicotine from reaching the brain and heart. It uses the liver to continuously produce antibodies, which eat up the nicotine before it enters the bloodstream, depriving smokers of their "fix."

"As far as we can see, the best way to treat chronic nicotine addiction from smoking is to have these Pac-Man-like antibodies on patrol, clearing the blood as needed before nicotine can have any biological effect," Crystal said. "[People] will know if they start smoking again, they will receive no pleasure from it due to the nicotine vaccine, and that can help them kick the habit."

Previously tested vaccines that delivered nicotine antibodies directly failed in clinical trials because they lasted only a few weeks and had inconsistent results.

In conducting the new study, researchers engineered a nicotine antibody and inserted it into a harmless virus. The vaccine was made to target liver cells, which, in turn, produce a steady stream of the nicotine antibodies.

When used on mice, the researchers found their vaccine produced high levels of the nicotine antibody, preventing the chemical from ever reaching the brain.

The researchers said the vaccine is completely safe and may someday even be used to prevent addiction to nicotine in people who never smoked.

"Just as parents decide to give their children a [human papillomavirus] vaccine, they might decide to use a nicotine vaccine," Crystal said. "We would, of course, have to weigh benefit versus risk, and it would take years of studies to establish such a threshold."

The study is scheduled for publication June 27 in the journal Science Translational Medicine.

More information

The American Cancer Society has more about how to quit smoking.

-- Mary Elizabeth Dallas

SOURCE: Weill Cornell Medical College, news release, June 27, 2012

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental drug improves muscle strength among male cancer patients
2. Experimental Drug Helps Fight Some Childhood Cancers, Study Finds
3. Experimental Drug Eases Autistic Behaviors in Mice
4. Experimental Gel May Help Those With Advanced Parkinsons
5. Experimental Pill for Multiple Sclerosis Shows Promise
6. Experimental Chemo Combo for Colon Cancer Disappoints
7. Controversial vaccine trial should never have been run in India, researchers say
8. Anti-cocaine vaccine described in Human Gene Therapy Journal
9. Control gene for conveyor belt cells could help improve oral vaccines, treat intestinal disease
10. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
11. Alzheimers vaccine trial a success
Post Your Comments:
Related Image:
Experimental Vaccine Seems to Stop Nicotine Addiction in Mice
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... Foundation (Meso Foundation) released information for caregivers and held two webinars on topics ... available on demand free of charge at . , With a ...
(Date:11/30/2015)... ... November 30, 2015 , ... Thermi™, a world ... announce that its ThermiRFR temperature controlled radiofrequency platform has received CE marking and ... platform which uses temperature as a clinical endpoint. The technology has been ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... vehicle experience this summer, ushering in a new era of publicly accessible automated ... electric shuttle, will continue to offer guests an up-close look at the shuttle ...
(Date:11/30/2015)... ... November 30, 2015 , ... On Saturday, October 24th, 2015, at the Mill ... fundraising event, a 5K walk known as “Making Strides Against Breast Cancer”. Patients and ... is also located in Battle Creek, joined in for this campaign that sought to ...
(Date:11/30/2015)... ... November 30, 2015 , ... During the week of ... raise funds for its research, education, support, and advocacy efforts. The campaign is ... , The Mesothelioma Applied Research Foundation, which also goes by Meso Foundation, holds ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 2015 North America was ... grow at a CAGR of 7.6% from 2015 to 2020. ... 135.6 million in 2014, and is expected to grow at a ... to the new Market Research Report "North America Cardiac Output Monitoring ... (Hospitals, ambulatory care, others) - Analysis And Forecast To 2020", the ...
(Date:11/30/2015)... --> --> ... by Product (Soft Tissue, All Tissue, Dental Welding Lasers), Application ... Geography - Global Forecast to 2020", published by MarketsandMarkets, is ... CAGR of 5.2% during the forecast period from 2015 to ... 62 Figures spread through 167 P ages and in-depth ...
(Date:11/30/2015)... MOUNTLAKE TERRACE, Wash. and ST. ... Cross and Express Scripts (NASDAQ: ESRX ) today ... benefit agreement. The partnership, which began in 1999, will ... --> --> After evaluating pharmacy ... process, Premera concluded that Express Scripts continues to offer ...
Breaking Medicine Technology: