Navigation Links
Experimental Vaccine Seems to Stop Nicotine Addiction in Mice
Date:6/27/2012

WEDNESDAY, June 27 (HealthDay News) -- A vaccine could someday help smokers kick the habit once and for all, according to a study that found the shot successfully treated nicotine addiction in mice in just one dose.

Although the findings hold promise, experts note that research involving animals frequently fails to lead to benefits for humans. In addition, the vaccine must be tested in rats and then primates before it can be tested in humans.

The researchers who developed the vaccine, however, say it could be the strategy that finally helps millions of smokers quit.

"While we have only tested mice to date, we are very hopeful that this kind of vaccine strategy can finally help the millions of smokers who have tried to stop, exhausting all the methods on the market today but finding their nicotine addiction to be strong enough to overcome these current approaches," the study's lead investigator, Dr. Ronald Crystal, chairman and professor of genetic medicine at Weill Cornell Medical College in New York City, said in a news release.

"Smoking affects a huge number of people worldwide, and there are many people who would like to quit but need effective help," he added. "This novel vaccine may offer a much-needed solution."

The vaccine works by preventing nicotine from reaching the brain and heart. It uses the liver to continuously produce antibodies, which eat up the nicotine before it enters the bloodstream, depriving smokers of their "fix."

"As far as we can see, the best way to treat chronic nicotine addiction from smoking is to have these Pac-Man-like antibodies on patrol, clearing the blood as needed before nicotine can have any biological effect," Crystal said. "[People] will know if they start smoking again, they will receive no pleasure from it due to the nicotine vaccine, and that can help them kick the habit."

Previously tested vaccines that delivered nicotine antibodies directly failed in clinical trials because they lasted only a few weeks and had inconsistent results.

In conducting the new study, researchers engineered a nicotine antibody and inserted it into a harmless virus. The vaccine was made to target liver cells, which, in turn, produce a steady stream of the nicotine antibodies.

When used on mice, the researchers found their vaccine produced high levels of the nicotine antibody, preventing the chemical from ever reaching the brain.

The researchers said the vaccine is completely safe and may someday even be used to prevent addiction to nicotine in people who never smoked.

"Just as parents decide to give their children a [human papillomavirus] vaccine, they might decide to use a nicotine vaccine," Crystal said. "We would, of course, have to weigh benefit versus risk, and it would take years of studies to establish such a threshold."

The study is scheduled for publication June 27 in the journal Science Translational Medicine.

More information

The American Cancer Society has more about how to quit smoking.

-- Mary Elizabeth Dallas

SOURCE: Weill Cornell Medical College, news release, June 27, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental drug improves muscle strength among male cancer patients
2. Experimental Drug Helps Fight Some Childhood Cancers, Study Finds
3. Experimental Drug Eases Autistic Behaviors in Mice
4. Experimental Gel May Help Those With Advanced Parkinsons
5. Experimental Pill for Multiple Sclerosis Shows Promise
6. Experimental Chemo Combo for Colon Cancer Disappoints
7. Controversial vaccine trial should never have been run in India, researchers say
8. Anti-cocaine vaccine described in Human Gene Therapy Journal
9. Control gene for conveyor belt cells could help improve oral vaccines, treat intestinal disease
10. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
11. Alzheimers vaccine trial a success
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Vaccine Seems to Stop Nicotine Addiction in Mice
(Date:6/27/2016)... ... June 27, 2016 , ... ... today announced its strategic partnership with Connance, a healthcare industry leader providing ... companies’ proven, proprietary technology combine to provide health systems, hospitals and ambulatory ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, ... the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where ... city’s history as home to some of the world’s leading providers of cereal and ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are confused ... endometriosis. These women need a treatment plan to not only alleviate symptoms and ... help for preservation of fertility and ultimately achieving a pregnancy. The specialists at ...
(Date:6/25/2016)... ... 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can ... CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn ... X . Simply select a ProHand generator and drag it above media or text ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
(Date:6/23/2016)... -- Revolutionary technology includes multi-speaker listening to ... leaders in advanced audiology and hearing aid technology, has ... the world,s first internet connected hearing aid that opens ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... firsts,: , TwinLink™ - the first dual ...
Breaking Medicine Technology: