Navigation Links
Experimental Vaccine Halts Prostate Cancer in Mice
Date:2/1/2008

Human trials may start in two years, California researcher says

FRIDAY, Feb. 1 (HealthDay News) -- An experimental prostate cancer vaccine has stopped the progress of the disease in 90 percent of the mice who got it, California researchers report.

"The vaccine turned the cancer into a chronic, manageable disease," said W. Martin Kast, lead author of a report published in the Feb. 1 issue of Cancer Research.

Twenty mice, genetically bred to develop prostate cancer, were given the vaccine in a two-step process, said Kast, a professor of molecular microbiology and immunology at the University of Southern California, Los Angeles.

When the mice were 8 weeks old, they got one injection consisting of a fragment of DNA that coded for prostate stem cell antigen (PSCA), a protein that is overproduced as prostate cancers grow. That injection alerted the immune system, Kast said.

A second shot, given two weeks later, used a modified horse virus to deliver the gene for PSCA, throwing the immune system into full action against the tumor.

Only two of the 20 vaccinated mice developed full-blown prostate cancer at the end of one year. Twenty other similarly bred mice who did not get the vaccine died of their cancers.

A vaccine for prostate cancer already exists, but it is only designed to extend survival for men in advanced stages of the disease and it has not been approved for use in the United States.

The new vaccine is designed to be used much earlier, Kast said. "Our vaccine approach would be to give it before you actually develop the disease," he said. Candidates for vaccination would be men who have high levels of prostate-specific antigen (PSA), a protein associated with the cancer.

Physicians now perform biopsies in most such cases, looking for evidence of cancer, which is usually inconclusive. The vaccine could be given instead of the "watchful waiting" now common for these men, Kast said.

The series of animal tests needed to prepare for a first human trial will take perhaps two years, Kast said. As for marketing the vaccine, he added, "I have already started to talk to some companies about this."

A precedent for such use already exists in the form of the vaccine against cervical cancer that is in medical use in the United States, Kast noted.

A new urine test that could help narrow the number of men diagnosed with possible prostate cancer was also described in the same issue of the journal.

"It is an extension of a current test," said Dr. Arul Chinnaiyan, director of the University of Michigan Center for Translational Pathology and lead author of the report.

The current test, developed at Michigan and marketed by the biotechnology company Gen-Probe, screens for one molecular marker of prostate cancer. The new test screens for four more key markers.

"It is for early screening to supplement PSA testing," Chinnaiyan said. "The benefit of this is that it could spare some people from some unnecessary biopsies. Eighty percent of men with high PSA levels don't have cancer. This could pick up 80 percent of them."

Both reports brought guarded reaction from Dr. Durado Brooks, director of prostate and colorectal cancers for the American Cancer Society.

The California work, Brook said, "is an interesting direction in terms of a way to develop a vaccine, but it is a long way from clinical use."

As for the new test, he added, while it could possibly reduce the number of biopsies, it does not fulfill the big hope for prostate cancer tests: distinguishing between slow-growing cancers that are best left alone and fast-growing malignancies that require quick and aggressive treatment.

"We really need a better handle on which prostate cancers will be more aggressive," he said.

Meanwhile, researchers at the U.S. National Cancer Institute report in the same journal that they have discovered genetic factors that drive the development of prostate cancer in black men, who are more likely to die of the disease than whites.

An analysis shows numerous differences in genes governing the immune response to cancer, they reported.

More information

Learn about prostate cancer from the U.S. National Cancer Institute.



SOURCES: W. Martin Kast, Ph.D, professor, molecular microbiology and immunology, University of Southern California, Los Angeles; Arul Chinnaiyan, M.D., Ph.D, director, University of Michigan Center for Translational Pathology, Ann Arbor; Durado Brooks, M.D., director, prostate and colorectal cancers, American Cancer Society; Feb. 1, 2008, Cancer Research


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
2. Experimental Antidepressants Offer Faster Relief
3. Experimental drug shows promise in advanced kidney cancer
4. Experimental drug boosts survival in recurrent ovarian cancer
5. Experimental cancer pharmaceuticals under trial
6. Experimental Drug Fails Against Heart Failure
7. Experimental Drug Fights Prostate Cancer
8. Experimental technique at GUMC offers real-time analysis of breast cancer biopsies
9. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
10. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
11. Vaccine Stops Alzheimers Brain Tangles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a missionary ... Journey: From the Mountains to the Mission Field” is the creation of published author, ... ages and currently teaches a class of ladies at her church, which she has ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized health ... expanded their existing home health joint venture through an agreement, effective October 1, ... joint venture home health company with Asante, delivering clinically integrated care, for the ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... for the 49th Congress of the International Society of Paediatric Oncology (SIOP) ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. ...
(Date:10/12/2017)... ... , ... In the United States, single-family home owners pay ... York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is $7,000 a ... rates, which contributes to the relatively lower cost of living in places like ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... -- AllianceRx Walgreens Prime, the combined central specialty pharmacy and ... manager Prime Therapeutics LLC (Prime), today officially began the ... of new signage at its headquarters in ... few other company-owned facilities across the country. This also ... whom will begin to see the AllianceRx Walgreens Prime ...
(Date:9/27/2017)... MIAMI , Sept. 27, 2017  Commended for their ... recent notable awards. Ranked as number one in the South ... ninth time in Inc. 5000 yearly list, the national specialty ... CEO, Armando Bardisa will soon be honored by ... Set to receive his award ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest ... Senators Bill Cassidy (R-LA) and Lindsey ... notes that the medical device industry is in an ... device tax, the 2.3% excise tax on medical device ... they also want covered patients, increased visits and hospital ...
Breaking Medicine Technology: