Navigation Links
Experimental Urine Test Spots Appendicitis
Date:6/23/2009

Holds promise for faster, more accurate diagnoses, researchers say

TUESDAY, June 23 (HealthDay News) -- A new urine test may one day spot appendicitis faster and more accurately than current tests do, researchers report.

Appendicitis is the most common surgical emergency in children, but the diagnosis can be challenging. An incorrect diagnosis can either lead to unnecessary surgery or a ruptured appendix with serious complications.

"We have found a protein in the urine that is diagnostic for appendicitis," said study co-author Hanno Steen, director of the Proteomics Center at Children's Hospital Boston. "This would mean that diagnosis of appendicitis is faster, more reliable and much more cost-efficient."

Ultrasound and computed tomography scans are used to diagnose appendicitis, yet 3 percent to 30 percent of children have unnecessary appendectomies, while 30 percent to 45 percent of those diagnosed with appendicitis already have a ruptured appendix, Steen noted.

In addition, patients can wait hours in the emergency room before they are able to have these tests, Steen said.

The report is published in the June 23 online edition of the Annals of Emergency Medicine.

For the study, Steen's team looked at urine samples from six patients with appendicitis and six without appendicitis. The researchers identified 32 possible biomarkers associated with the condition. To these, they added other markers found in gene studies.

Steen's group then looked for these 57 potential markers in 67 children with possible appendicitis. Among these children, 25 actually did have appendicitis, the researchers noted.

From this study, the researchers identified seven biomarkers linked with appendicitis. Of these, leucine-rich alpha-2-glycoprotein appeared to be the best -- with few false-positive or false-negative results.

Based on these results, Steen's group hopes to develop a rapid clinical test, such as a urine dipstick, that could be widely used to identify children and adults with appendicitis.

This test could diagnose appendicitis in 30 minutes and result in fewer unnecessary surgeries, Steen said.

But first, the test has to be tried in a larger group of patients, Steen said. In addition, they want to test the findings in adults.

"We have to show the test works in adults," Steen said. "We also have to do a much larger study so we can do proper statistics."

Dr. Marshall Morgan, chief of emergency medicine at UCLA Medical Center in Los Angeles, said he thinks this preliminary study could result in a better way to diagnose appendicitis in the future.

"This is interesting, even exciting, in that it describes a new approach to a difficult and common diagnostic problem," Morgan said. "On the other hand, this is early work which is not nearly ready for clinical application at this point."

More information

For more information on appendicitis, visit the U.S. National Institute of Diabetes and Digestive and Kidney Diseases.



SOURCES: Hanno Steen, Ph.D., director, Proteomics Center, Children's Hospital Boston; Marshall Morgan, M.D., director, emergency medicine, UCLA Medical Center, Los Angeles; June 23, 2009, Annals of Emergency Medicine, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
2. Experimental Antidepressants Offer Faster Relief
3. Experimental drug shows promise in advanced kidney cancer
4. Experimental drug boosts survival in recurrent ovarian cancer
5. Experimental cancer pharmaceuticals under trial
6. Experimental Drug Fails Against Heart Failure
7. Experimental Drug Fights Prostate Cancer
8. Experimental technique at GUMC offers real-time analysis of breast cancer biopsies
9. Experimental Vaccine Halts Prostate Cancer in Mice
10. Experimental Biology 2008 Todays Research: Tomorrows Health, April 5-9
11. 52 minority scientists receive travel fellowships to Experimental Biology 2008
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Urine Test Spots Appendicitis 
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed at nurses and employees ... which come courtesy of leaders in the nursing and health care industry. It also ... and associations—namely Abilene Christian University. , As the nursing industry is coming out ...
(Date:5/26/2016)... ... ... Despite last week’s media reports hinting at a June rate hike after the Federal ... an interest rate increase, according to Rajeev Dhawan of the Economic Forecasting Center at ... Committee (FOMC) dot charts are of interest to the press for their noise potential,” ...
(Date:5/26/2016)... California (PRWEB) , ... May 26, 2016 , ... ... associated with discovery of thousands of defective respirators, according to court documents and ... the case of William and Becky Tyler v. American Optical Corporation, Case No. ...
(Date:5/26/2016)... ... May 26, 2016 , ... Connor Sports, through its ... partner for the Tamika Catchings Legacy Tour that will commemorate the Indiana ... hardwood basketball surfaces in all forms and levels of the game, Connor Sports has ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... a significant negative impact on long-term patient survival, reports a team of UPMC ... online this week in the Journal of Thoracic and Cardiovascular Surgery, provide critical ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... India , May 25, 2016 ... Animation Market by Type (3D, 2D, 4D), by Therapeutic ... Education), by End User (Medical Device Manufacturers, Hospitals/ Clinics) ... studies the global Medical Animation Market for the forecast ... to reach USD 301.3 Million by 2021 from USD ...
(Date:5/25/2016)... and GERMANTOWN, Maryland , May ... QGEN ; Frankfurt Prime Standard: QIA) today announced that ... with Therawis Diagnostics GmbH to develop and commercialize predictive assays ... market PITX2 as a marker to predict effectiveness of anthracycline ... "We are pleased to partner with Therawis, which ...
(Date:5/25/2016)... -- According to Kalorama Information, the world market for ... these are challenging times in the market, there ... companies that remain optimistic and seek innovation.  Toward ... medical device companies spend a higher percentage of ... do companies in other industries.  Also, in addition ...
Breaking Medicine Technology: