Navigation Links
Experimental Psoriasis Drug Bests Older Treatment
Date:10/27/2011

By Serena Gordon
HealthDay Reporter

WEDNESDAY, Oct. 26 (HealthDay News) -- An experimental psoriasis treatment performed significantly better than the commonly prescribed medication methotrexate in a new clinical trial.

The drug briakinumab reduced psoriasis symptoms by at least 75 percent in nearly 82 percent of those taking it, compared to just 40 percent of those on methotrexate. But serious side effects were more common among the briakinumab users.

"Very high levels of response" were observed and maintained throughout the study period, said lead researcher Dr. Kristian Reich, a professor of dermatology at the University of Gottingen and a managing partner at Dermatologikum Hamburg, both in Germany.

Results of the study are published in the Oct. 27 issue of the New England Journal of Medicine. The study was funded by the drug's manufacturer, Abbott Laboratories.

Psoriasis affects about 5 million Americans, according to the U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The disease causes patches of thick, red, inflamed skin that have silvery scales. Psoriasis can affect any part of the body, including the skin, nails, genitals and inside the mouth, according to NIAMS.

The current study included 317 people with moderate to severe psoriasis. The study volunteers had had psoriasis for at least six months, and the condition affected at least 10 percent of their bodies.

Nearly half of the study participants were randomly selected to receive injections of briakinumab at a dose of 200 milligrams (mg) for the first and fourth week of the study, and 100 mg at week eight and every four weeks thereafter. The study lasted one year. The remaining volunteers were given between 5 mg and 25 mg of oral methotrexate weekly.

After six months, nearly 82 percent of those in the briakinumab group had at least a 75 percent improvement in the psoriasis area-and-severity index (PASI), a commonly used measurement to assess the severity of psoriasis. Slightly less than 40 percent of those on methotrexate had a 75 percent improvement in their PASI score, according to the study.

After a year, about 66 percent of those taking briakinumab had a 75 percent improvement in their PASI score compared to almost 24 percent for those on methotrexate, according to the study.

Briakinumab works by dampening the immune system response that causes psoriasis, said Bruce Bebo, director of research and medical programs for the National Psoriasis Foundation, based in Portland, Ore.

More serious infections were seen in people taking briakinumab (2.6 percent) vs. those taking methotrexate (1.8 percent). There were also two cases of cancer in people taking briakinumab and none in the methotrexate group. However, the researchers said these differences weren't statistically significant.

"Cancer risk is extremely hard to define, and this study was not powered to detect any difference in the risk of developing a malignancy," said Bebo.

He said that in an earlier trial of briakinumab, some unexplained major adverse cardiac events occurred. At the time, Abbott withdrew its application for approval from the U.S. Food and Drug Administration pending further research. In the current study, no serious cardiovascular events were reported.

Of the increased infections and cancers, Reich said, "Although these differences were not statistically significant, they lead to questions regarding a favorable risk-benefit profile of the drug."

Research on briakinumab is continuing. An ongoing three-year trial involves 248 people from the current study.

For people living with psoriasis, Bebo said the message from this study is that "dramatic progress has been made from where we were just five years ago."

More information

Learn more about psoriasis treatments from the National Psoriasis Foundation.

SOURCES: Kristian Reich, M.D., professor, dermatology, University of Gottingen, and managing partner, Dermatologikum Hamburg, Germany; Bruce Bebo, Ph.D., director, research and medical programs, National Psoriasis Foundation, Portland, Ore.; Oct. 27, 2011, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental Drug Offers Hope for Cystic Fibrosis Patients
2. Experimental Vaccine Shields Monkeys Against Ebola
3. Experimental targeted therapy shows early promise against medulloblastomas
4. Experimental nonsteroidal treatment of asthma shows promise
5. Experimental obesity drug avoids brain effects that troubled predecessors
6. Experimental treatments for cocaine addiction may prevent relapse
7. Experimental TB Test Called Fast and Accurate
8. Experimental Drug Shows Promise for Bone Marrow Disorder
9. Experimental Leukemia Drug Proves a Slam Dunk
10. Experimental Test May Spot Prostate Cancer Earlier, More Accurately
11. Experimental Drug Aids Kids With Nervous System Tumor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Psoriasis Drug Bests Older Treatment
(Date:5/23/2017)... , ... May 23, 2017 , ... ... North Carolina have remained steady since 2009, according to a Workers Compensation Research ... The study Monitoring the North Carolina System: CompScope™ Benchmarks, 17th Edition ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... and a 2017 Best in KLAS category winner, has named Daniel P. Bullington ... extend and enhance its technology platform and product offerings,” says Justin Neece, president. ...
(Date:5/23/2017)... ... , ... London, May 23, 2017: Walter Schindler, the Founder and Managing Partner ... Speaker and Contributor to a weeklong series of classes, meetings, field trips and special ... Walter Schindler and SAIL Capital have received an increasing number of ...
(Date:5/23/2017)... ... May 23, 2017 , ... By all indications, and due to months of ... call for diligence, asking homeowners to scout for any open water sources that can ... the annoying buzz of mosquitos is the buzz associated with potential infections stemming from ...
(Date:5/23/2017)... ... May 23, 2017 , ... MedTech For Solutions has announced ... laboratory, to provide hands-on training utilizing cutting-edge equipment at its recently-opened OvaTools Andrology ... MedTech Group Purchasing vendor , will provide specialized equipment to ensure OvaTools participants ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... May 4, 2017  A new tight-tolerance microextrusion ... other highly-engineered materials, is being launched by Natvar, ... been developed in recent years to service a ... surgical applications. More expensive materials such as glass ... tubing due to their ability to consistently hold ...
(Date:5/3/2017)... 2017  Kalorama Information notes that transplant diagnostics ... year and this is projected to continue to ... (HSCT) or bone marrow transplants require histocompatibility between ... for this task. This according to a new ... The various PCR-based methodologies, Sanger sequencing and NGS ...
(Date:5/2/2017)... and NEW YORK ... As the leading distributor of market intelligence, ... European Med Tech Reimbursement Consulting AB that ... Tech Reimbursement Consulting AB,s proprietary market analyses through the ... professionals around the world easy access to complete product ...
Breaking Medicine Technology: