Navigation Links
Experimental Drug Slims Obese Monkeys

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, Nov. 9 (HealthDay News) -- An experimental drug that targets and kills fat cells in the blood appears to help obese rhesus monkeys lose weight, a new study suggests.

In the future, this approach may help obese humans lose weight, according to the University of Texas M.D. Anderson Cancer Center researchers.

"Targeting blood vessels of white fat tissue is a novel conceptual approach against obesity," said study author Dr. Wadih Arap, the Stringer Professor of Medicine and Experimental Diagnostic Imaging at M.D. Anderson. "Adipotide is a new drug candidate against obesity to be translated into potential clinical applications in humans."

The report was published in the Nov. 9 issue of Science Translational Medicine.

The usual way drugs work to counter obesity is either by suppressing appetite or by increasing metabolism to try to burn calories faster, the investigators noted.

However, this new drug works by attaching itself to fat cells in the blood vessels and triggering a synthetic protein that causes the cell to die. These cells are then reabsorbed and metabolized, the researchers explained.

When the drug was tried on monkeys that were naturally obese they lost about 11 percent of their body weight over a month, Arap's team found.

In addition, the treated monkeys also improved their insulin resistance, which is a marker for developing type 2 diabetes. After treatment, the monkeys used 50 percent less insulin, the researchers found.

"Moreover, the monkeys lost 27 percent of abdominal white fat after Adipotide treatment," Arap said.

When the drug was given to lean monkeys they did not lose weight, suggesting that the drug may just select obese animals.

The drug did not have any adverse side effects, the researchers said, adding that the monkeys were "bright and alert throughout, interacting with caretakers and demonstrating no signs of nausea or food avoidance."

Within a month after treatment was stopped the monkeys started to gain weight again, the study authors noted.

The researchers are planning to test the drug on prostate cancer patients. These patients are prone to weight gain during hormone therapy, which can lead to arthritis-causing inactivity and a host of other health problems.

In addition, fat cells produce growth hormones that help cancer cells thrive, the researchers explained.

In this study, patients would receive injections of adipotide for 28 days.

"There is an increasingly clear scientific and medical interplay among obesity, metabolic syndrome and several human cancers, such as prostate, breast, colon, ovarian, among others," Arap said.

"Basically, we are in a cancer center and our group in particular has long been interested in this matter as a potentially new therapeutic in prostate cancer patients," he said.

Obesity expert Dr. David L. Katz, director of the Prevention Research Center at Yale University School of Medicine, said that "for those hopeful that pharmacotherapy might ultimately help us overcome epidemic obesity, this study serves up a preliminary dose of encouraging news."

This good news comes in a precautionary package of prior experience, Katz noted. "A study of nine weeks in a small group of genetically select monkeys is a very far cry from evidence in people, in the real world, over a meaningful span of time," he said.

Even weight-loss drugs that appeared to perform well in people over time like rimonabant and sibutramine have all led to disappointment, either because of waning effectiveness or toxicity, Katz noted.

"Adipotide may prove an exception to this rule, but believing it now would be the triumph of hope over experience," Katz said.

"This should not distract us from how much good we could reliably get done right now if we focused on turning what we already know about the power of feet and forks into what we routinely do," he added.

More information

For more information on obesity, visit the U.S. National Library of Medicine.

SOURCES: Wadih Arap, M.D., Ph.D., Stringer Professor of Medicine and Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston; David L. Katz, M.D., M.P.H., director, Prevention Research Center, Yale University School of Medicine, New Haven, Conn.; Nov. 9, 2011, Science Translational Medicine

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental Drug Offers Hope for Cystic Fibrosis Patients
2. Experimental Vaccine Shields Monkeys Against Ebola
3. Experimental targeted therapy shows early promise against medulloblastomas
4. Experimental nonsteroidal treatment of asthma shows promise
5. Experimental obesity drug avoids brain effects that troubled predecessors
6. Experimental treatments for cocaine addiction may prevent relapse
7. Experimental TB Test Called Fast and Accurate
8. Experimental Drug Shows Promise for Bone Marrow Disorder
9. Experimental Leukemia Drug Proves a Slam Dunk
10. Experimental Test May Spot Prostate Cancer Earlier, More Accurately
11. Experimental Drug Aids Kids With Nervous System Tumor
Post Your Comments:
Related Image:
Experimental Drug Slims Obese Monkeys
(Date:6/27/2016)... ... 27, 2016 , ... TherapySites, the leading website ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to ... adding exclusive benefits and promotional offers. , "TCA is extremely excited about this ...
(Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: ... 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) assay ... sepsis or septic shock. With this clearance, Roche is ... a fully integrated solution for sepsis risk assessment and ... with bacterial infection and PCT levels in blood can ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... offering. The current unmet ... for MedImmune to enter. The US ageing population creates a ... considerable growth for effective anti-influenza medications. The introduction of a ... development is still in its infancy. Key ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
Breaking Medicine Technology: