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Experimental Drug Shows Promise for Bone Marrow Disorder
Date:9/15/2010

however, that researchers had initially held out hope that the drug under investigation might even have a more dramatic impact on symptoms, given the key role JAK2 mutations appear to play in development of the disease.

"But at least there was some palliation for a group of patients," Kirschbaum said. "And this certainly represents an encouraging first step towards more definitive treatment for this nasty disorder."

The study was funded by Incyte Corporation, which developed the JAK2-inhibitor, and Verstovsek has received research funding from the company. The research is ongoing in the United States, Canada, Australia and Europe.

More information

For more on myelofibrosis, visit the U.S. National Library of Medicine.

-- Alan Mozes

SOURCES: M.D. Anderson Cancer Center, news release, Sept. 15, 2010; Mark H. Kirschbaum, M.D., director, developmental therapeutics, and acting chair, hematology, Nevada Cancer Institute, Las Vegas


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