Navigation Links
Experimental Drug Shows Promise for Bone Marrow Disorder
Date:9/15/2010

gned to shut down the abnormal activity of JAK2 gene mutations, which have been found to be responsible for the over-growth of bone marrow cells, and have been linked to many cases of myelofibrosis.

The researchers initially began testing the drug in about 150 patients who had advanced-stage myelofibrosis or were newly diagnosed (in 2007) with high-intermediate or high-risk disease. Ongoing work will focus on 115 of these patients.

Verstovsek and his colleagues have so far found that one month after treatment with INCB018424, about half of the patients experienced a 50 percent reduction in symptom scores, and nearly 60 percent of these patients maintained this drop a half-year out.

Between 70 percent and 82 percent of the patients experienced a minimum of a 25 percent reduction in spleen size after taking the experimental drug for two months -- a drop that endured for more than a year.

And MRI scans revealed that by the six-month treatment mark, on average, patients achieved a reduction in spleen size of about one-third, with nearly half experiencing a spleen size shrinkage of 35 percent or more.

Improvement in the ability to exercise and average weight gains of about 15 to 20 pounds following one-year of treatment were also evident, the report indicated.

Even patients who did not have the JAK2 mutation that the drug was designed to attack seemed to benefit from the new treatment, the researchers said.

"This suggests that patients who do not have specific mutations still have a very active JAK signaling pathway and can benefit from JAK inhibition," Verstovsek said. "However, because the drug also inhibits normal JAK2, it can lead to low blood counts that can limit dosing."

Dr. Mark H. Kirschbaum, director of developmental therapeutics and acting chair of hematology at the Nevada Cancer Institute in Las Vegas, called the research "a first breakthrough" in the attempt to tackle myelofibrosis.

Kirschbaum cautioned,
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Experimental TB Test Called Fast and Accurate
2. Experimental treatments for cocaine addiction may prevent relapse
3. Experimental obesity drug avoids brain effects that troubled predecessors
4. Experimental nonsteroidal treatment of asthma shows promise
5. Experimental targeted therapy shows early promise against medulloblastomas
6. Experimental Vaccine Shields Monkeys Against Ebola
7. Experimental Drug Offers Hope for Cystic Fibrosis Patients
8. Report shows federal poverty guidelines leave states seniors destitute
9. Study shows tranquil scenes have positive impact on brain
10. Targeted agent shows promise for chronic lymphoid leukemia
11. Research shows unemployment programs lacking for people with disabilities
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Drug Shows Promise for Bone Marrow Disorder
(Date:12/25/2014)... Dec. 25, 2014 (HealthDay News) -- Overeating is common during ... eat in moderation, an expert says. "Don,t arrive at ... calories if you know you,ll be attending a party, but ... Ashbey-Pejoves, lead dietitian at Northern Westchester Hospital in Mount Kisco, ... to eat healthy during the day and even to have ...
(Date:12/25/2014)... Thompson HealthDay Reporter WEDNESDAY, ... in on a "fountain of youth" drug that can delay ... adults, a new study suggests. Seniors received a significant ... targets a genetic signaling pathway linked to aging and immune ... The experimental medication, a version of the drug rapamycin, ...
(Date:12/25/2014)... Thousands of transvaginal mesh lawsuits ( ... number of multidistrict litigations currently underway in U.S. District ... reports. According to an Order issued on December 2, ... Status Conference in all of the proceedings on January ... to submit a proposed agenda to the Court by ...
(Date:12/25/2014)... Plugin creators from Pixel Film Studios have ... business presentation tool made specifically for Final Cut ... tool, users can now display their stats and facts ... Studios. “ProFire 5k gives users a multiple options to ... a presentation” , Pixel Film Studios takes the heat ...
(Date:12/25/2014)... 2014 Each year trauma accounts for ... hospital admissions across the nation (according to the ... CDC’s National Hospital Ambulatory Medical Care Survey collected ... in 2010. They estimated that there were between 3.5 ... a primary diagnosis of broken bone or fracture. ...
Breaking Medicine News(10 mins):Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... Patients, cognition improved as medication rid brain of matted protein, ... A drug that aims to reduce the clogging "tangles" in ... in early trials, researchers report. , Further studies are necessary ... Alzheimer,s as it seems, or whether it needs to be ...
... U.S. Surgeon General,Julius B. Richmond, MD, FAAP, a pediatrician ... July 27, 2008, of,cancer at his home near Boston. ... Carter,s Assistant Secretary for,Health and as U.S. Surgeon General ... tobacco control efforts through the release of,the 1979 Surgeon ...
... Sanaria Inc., a,privately held company in Rockville, ... (UMBI) announced the receipt of a,multi-year Small ... Institute of Allergy and Infectious Diseases (NIAID) ... will support research and,development efforts to genetically ...
... July 29 Genomma Lab,Internacional, S.A.B. de C.V. ... over-the-counter pharmaceuticals and personal care products,company announced yesterday ... and registrations of UNIGASTROZOL, from Unipharm de Mexico, ... the reduction and control of,gastrointestinal symptoms that are ...
... Study urges national, international standards to ensure safety, reliable ... testing has become a common part of cancer care ... American Thoracic Society guidelines, say Duke University Medical Center ... to determine the pre-surgical fitness of lung cancer patients. ...
... of Gillette, brings 38 years of ... experience in consumer products industry, CHICAGO, July 29 ... that Peter Klein has joined the,firm as a director., ... consumer products,industry and was most recently senior vice president and ...
Cached Medicine News:Health News:'De-Tangling' Alzheimer's Drug Shows Promise 2Health News:'De-Tangling' Alzheimer's Drug Shows Promise 3Health News:'De-Tangling' Alzheimer's Drug Shows Promise 4Health News:Former U.S. Surgeon General Julius B. Richmond, 91 2Health News:Former U.S. Surgeon General Julius B. Richmond, 91 3Health News:Malaria Vaccine Developer Sanaria Inc. and the University of Maryland Biotechnology Institute Awarded Collaborative, Multi-Year, US $600,000 NIH Phase I Small Business Innovation Research Grant 2Health News:Malaria Vaccine Developer Sanaria Inc. and the University of Maryland Biotechnology Institute Awarded Collaborative, Multi-Year, US $600,000 NIH Phase I Small Business Innovation Research Grant 3Health News:Genomma Lab Internacional Acquires UNIGASTROZOL 2Health News:Exercise Testing for Cancer Fails to Follow Guidelines 2Health News:The Cambridge Group Names Peter Klein a Director 2
(Date:12/24/2014)... and FARMINGTON, Conn. , Dec. ... MKT: PTN), a biopharmaceutical company developing targeted, receptor-specific ... significant unmet medical need and commercial potential, today ... placement of 2,050,000 shares of its common stock ... of its common stock.  Funds under the management ...
(Date:12/24/2014)... DIEGO , Dec. 23, 2014 ResMed (NYSE: ... significant patent infringement action against Chinese medical device manufacturer BMC ... (ITC) ruled today that BMC,s masks listed below infringe ResMed,s ... or selling these masks in the United States ... iVolve N2 nasal mask , Willow nasal pillows mask ...
(Date:12/24/2014)... 23, 2014  The American Diabetes Association is ... for people with diabetes and that all people ... of statins, in keeping with recent changes to ... American College of Cardiology (ACC) and American Heart ... most recent changes to the Association,s annual revised ...
Breaking Medicine Technology:Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: