Navigation Links
Experimental Drug Shows Promise Against Cushing's Disease
Date:3/7/2012

WEDNESDAY, March 7 (HealthDay News) -- An experimental drug called pasireotide reduced levels of the "stress hormone" cortisol and improved symptoms in patients with Cushing's disease, a new study found.

Cushing's disease is a rare (three to five cases per million people) hormonal disorder that causes a wide range of health problems and, if untreated, significantly increases a patient's risk of dying at a much younger age than normal, researchers said in a news release.

Weight gain, high blood pressure, mood swings, irregular or absent menstrual periods, insulin resistance, glucose intolerance and type 2 diabetes are among the symptoms of Cushing's disease. It is a form of Cushing's syndrome, which is caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol.

This phase 3 study of 162 patients in 18 countries found that treatment with pasireotide reduced cortisol secretion by an average of 50 percent and returned some patient's cortisol levels to normal.

A phase 3 study means that a drug is in the final stages of testing that drugs undergo before they can be approved for treatment of a specific disease.

The study, funded by Novartis Pharma, appears in the March 8 issue of the New England Journal of Medicine.

Dr. Spyros Mezitis, an endocrinologist at Lenox Hill Hospital in New York City, is not associated with the study but is familiar with its findings.

Mezitis said the study showed that the experimental treatment "improved metabolic abnormalities and emotional difficulties. Therefore, pasireotide injections become an alternative to surgical resection of the pituitary ACTH-secreting tumor, and may be shown to work with the FDA-approved mifepristone, which blocks the action of cortisol at receptors in the body."

Elevated blood sugar (glucose) levels occurred in 73 percent of the patients who took the drug, a side effect that requires close attention, acc
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Experimental Drug Offers Hope for Rare Bone Disease: Study
2. Experimental Drug Shows Promise Against Type 2 Diabetes
3. First-in-human drug for malignant glioma available in experimental trial
4. Experimental Drug Might Beat Aspirin in Preventing Repeat Strokes: Study
5. Experimental Drugs Do Battle Against Advanced Prostate Cancer
6. Experimental Blood Thinner Given Before Surgery Shows Benefit
7. Wolfson Foundation awards £20 million to UCL for experimental neurology center
8. Novel experimental agent is highly active in CLL patients, interim study shows
9. Experimental Drug for Irregular Heart Rhythm Raises Death Risk: Study
10. Experimental Drug Slims Obese Monkeys
11. Experimental Psoriasis Drug Bests Older Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Drug Shows Promise Against Cushing's Disease
(Date:5/22/2015)... 2015 Power Systems is proud to announce ... race season. Drobeck is in his second year of racing ... with the Missoula Fire Department in Missoula, MT. He entered ... 2014. During his career, he has had 15 1st Place ... top 10 finishes in all seven of his 2014 races, ...
(Date:5/22/2015)... PA (PRWEB) May 22, 2015 According to ... a hub for drug related death, totaling almost 2,500 confirmed ... as reported by state officials, totals 2,489 deaths stemming from ... work out, Pennsylvania loses seven people every day to fatal ... has been singled out as one of the most rife ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Medivo, Inc., a ... “Positivity Rates and Genotype Results in ‘Baby Boomers’ Screened for ... a Nationwide Lab Test Database” at Digestive Disease Week, May ... Clinical Affairs and Analytics team members Carol Smyth, MB; Jason ... Andrea Parker, MSI, along with Nancy Reau, MD from the ...
(Date:5/22/2015)... 22, 2015 Wimbledon Health Partners, the ... (EKG), echocardiogram and NCV testing , is proud ... respected All American National athlete, to the Wimbledon Athletics ... the high level of testing and information it provides ... their athletic trainers, this way they can focus on ...
(Date:5/22/2015)... Phoenix, AZ (PRWEB) May 22, 2015 ... Special Olympics, Parker and Sons is offering to donate ... for installing an AC unit or water softening system. ... their behalf; Parker and Sons gets business; and the ... , The Special Olympics helps over 4.4 million ...
Breaking Medicine News(10 mins):Health News:Philadelphia Ranks Among the Tops Cities in Penn. for Drug Deaths 2Health News:Medivo Study Finds HCV Positivity Rates are 250% Higher Among Baby Boomers 2Health News:Wimbledon Athletics Recruits Team USA Athlete 2Health News:Wimbledon Athletics Recruits Team USA Athlete 3Health News:Parker and Sons is Proud to Support the Special Olympics with Their Everybody Wins Program 2
... May 23, 2011 -- The next agricultural revolution may ... the growing needs of the planet without the need for ... the 111th General Meeting of the American Society for Microbiology ... by the year 2050 the global human population is expected ...
... MONDAY, May 23 (HealthDay News) -- Cancer patients who are ... sense of satisfaction about their treatment, a new study finds. ... accurate medical information built trust between patient and doctor. ... the study analyzed 295 patients recently diagnosed with lymphoma, breast ...
... is a very common complaint, with over 90% of ... their lives. Headaches commonly are tension-type (TTH) or migraine. ... daily activities. Treatments range from pharmacologic to behavioral interventions. ... Journal of Manipulative and Physiological Therapeutics, a group ...
... Children,s Hospital Boston and collaborators at other institutions has ... cells produce new bone in response to mechanical stresses, ... developing new strategies for treating diseases characterized by low ... imperfecta in children. The research team, led by ...
... , SATURDAY, May 21 (HealthDay News) -- Football players ... they hit the training field in August, an expert ... and other potentially serious heat-related injuries, according to Dr. ... Medicine in Houston. Heat-related illnesses have claimed the ...
... Georgetown University Medical Center,s Howard J. Federoff, MD, ... along with advocates, at the "One Mind for Research ... understanding and treatment of brain disorders. By uniting ... new 10-year research agenda for the field of neuroscience. ...
Cached Medicine News:Health News:Fungi reduce need for fertilizer in agriculture 2Health News:Cancer Patients Benefit From Full Access to Medical Records 2Health News:Substantial recovery rate with placebo effect in headache treatment 2Health News:A direct path for understanding and treating brittle bones 2Health News:A direct path for understanding and treating brittle bones 3Health News:Football Players Urged to Beat the Heat 2Health News:'The Potential to Modify the Course of Parkinson's Disease' 2
(Date:5/21/2015)... , May 21, 2015 ... announced the addition of the "North American ... Graft), by Application (Surgical Wound, & Ulcer), by ... to 2019" report to their offering. ,     ... care market is estimated to grow at a ...
(Date:5/21/2015)...  CryoLife, Inc. (NYSE: CRY ), a leading ... and vascular surgery, announced today that its Board of ... second quarter 2015 of $0.03 per share of common ... share will be paid on June 19, 2015 to ... 2015.  The ex-dividend date for the quarterly dividend is ...
(Date:5/21/2015)... , May 21, 2015 The ... statement regarding the Medicare Part D offsets included ... Cures initiative: "If the 21st Century Cures ... from America,s premier health program – Medicare – ... may yield down the road. "Leveraging ...
Breaking Medicine Technology:North American Active Wound Care Market 2015-2019 with Smith and Nephew, Molyncke HealthCare & ConvaTec Dominating 2CryoLife Announces Quarterly Cash Dividend for the Second Quarter 2015 2
... Inc. (Nasdaq: DCTH ) announced today that it has ... common stock at $3.60 per share, or $30.6 million, pursuant ... the Company has granted the underwriters of the offering an ... primary stock to cover over-allotments. The offering is expected ...
... NEW YORK, Nov. 12 Reportlinker.com announces ... available in its catalogue. , ... to 2015 , ... Market Analysis & Forecasts to 2015 , ...
Cached Medicine Technology:Delcath Systems, Inc. Prices $30.6 Million Stock Offering 2Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 2Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 3Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 4Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 5Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 6Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 7Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 8Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 9Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 10Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 11Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 12Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 13Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 14Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 15Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 16Reportlinker Adds US Orthopedic Devices Market Analysis & Forecasts to 2015 17
2.0mm Rounded Tip, 12mm From Tip to Bend Gently Curved, 15mm Shaft; In Titanium...
Angled 40 Degrees, 0.6x0.8 Elliptical Tip; in Titanium...
0.5X2.0mm Tip, Oval Shape; in Titanium....
30 Degree Angle Shaft with 1.0mm 90 Degree Angle Tip; in stainless steel....
Medicine Products: