Navigation Links
Experimental Drug Shows Promise Against Cushing's Disease
Date:3/7/2012

WEDNESDAY, March 7 (HealthDay News) -- An experimental drug called pasireotide reduced levels of the "stress hormone" cortisol and improved symptoms in patients with Cushing's disease, a new study found.

Cushing's disease is a rare (three to five cases per million people) hormonal disorder that causes a wide range of health problems and, if untreated, significantly increases a patient's risk of dying at a much younger age than normal, researchers said in a news release.

Weight gain, high blood pressure, mood swings, irregular or absent menstrual periods, insulin resistance, glucose intolerance and type 2 diabetes are among the symptoms of Cushing's disease. It is a form of Cushing's syndrome, which is caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol.

This phase 3 study of 162 patients in 18 countries found that treatment with pasireotide reduced cortisol secretion by an average of 50 percent and returned some patient's cortisol levels to normal.

A phase 3 study means that a drug is in the final stages of testing that drugs undergo before they can be approved for treatment of a specific disease.

The study, funded by Novartis Pharma, appears in the March 8 issue of the New England Journal of Medicine.

Dr. Spyros Mezitis, an endocrinologist at Lenox Hill Hospital in New York City, is not associated with the study but is familiar with its findings.

Mezitis said the study showed that the experimental treatment "improved metabolic abnormalities and emotional difficulties. Therefore, pasireotide injections become an alternative to surgical resection of the pituitary ACTH-secreting tumor, and may be shown to work with the FDA-approved mifepristone, which blocks the action of cortisol at receptors in the body."

Elevated blood sugar (glucose) levels occurred in 73 percent of the patients who took the drug, a side effect that requires close attention, according to senior study author Dr. Beverly Biller, of Massachusetts General Hospital.

Cushing's patients already have difficulty processing glucose, she noted.

"Those patients who already were diabetic had the greatest increases in blood sugar, and those who were prediabetic were more likely to become diabetic than those who began with normal blood sugar," Biller said in the hospital news release. "So this is real and needs to be monitored carefully."

Mezitis agreed that careful patient monitoring is important. "Blood-sugar elevations are dose-dependent with pasireotide and will need to be managed as indicated for diabetes," he said.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about Cushing's syndrome.

-- Robert Preidt

SOURCES: Spyros Mezitis, M.D., endocrinologist, Lenox Hill Hospital, New York City; Massachusetts General Hospital, news release, March 7, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental Drug Offers Hope for Rare Bone Disease: Study
2. Experimental Drug Shows Promise Against Type 2 Diabetes
3. First-in-human drug for malignant glioma available in experimental trial
4. Experimental Drug Might Beat Aspirin in Preventing Repeat Strokes: Study
5. Experimental Drugs Do Battle Against Advanced Prostate Cancer
6. Experimental Blood Thinner Given Before Surgery Shows Benefit
7. Wolfson Foundation awards £20 million to UCL for experimental neurology center
8. Novel experimental agent is highly active in CLL patients, interim study shows
9. Experimental Drug for Irregular Heart Rhythm Raises Death Risk: Study
10. Experimental Drug Slims Obese Monkeys
11. Experimental Psoriasis Drug Bests Older Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Drug Shows Promise Against Cushing's Disease
(Date:2/23/2017)... ... February 23, 2017 , ... The 89th Academy Awards ... of the 2016 National Education Policy Center Bunkum Award. We invite you to enjoy ... , This year’s Bunkum winner is the Center for American Progress (CAP), for its ...
(Date:2/23/2017)... ... February 23, 2017 , ... Hamlin Dental Group and Dr. ... are sponsoring a raffle. Throughout the month of February, patients who visit Hamlin Dental ... card for a dinner for two at the Cheesecake Factory. , Tickets are ...
(Date:2/23/2017)... Colorado (PRWEB) , ... February 23, 2017 , ... ... Magazine, an exciting, new, interactive publication where generations converge and explore the world ... expand their worldview, Dialog Magazine enables readers to gain understanding, increase empathy, and ...
(Date:2/23/2017)... ... (PRWEB) February 23, 2017 -- ... to come together to combine its favorite springtime pastime – ... fruit – apples! To celebrate National Nutrition Month, the U.S. ... Madness” bracket tournament – a five-week, five-round online competition spotlighting ...
(Date:2/23/2017)... ... February 23, 2017 , ... Thomas Vas-Don suffered ... exercise regime, the author was able to successfully recover. In “ Origin & Insertion ... for various sources on the principals of massage, anatomy , trigger points ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Feb. 23, 2017 Research and Markets has ... Strategies - 2016" report to their offering. ... The latest research Fibromyalgia Drugs ... benchmarks in the global Fibromyalgia market. The research answers ... drugs marketed for Fibromyalgia and their clinical attributes? How are they ...
(Date:2/23/2017)... , Feb 23, 2017 Research and ... Analysis & Trends - Industry Forecast to 2025" report to ... ... of around 6.9% over the next decade to reach approximately $47.6 ... market estimates and forecasts for all the given segments on global ...
(Date:2/23/2017)... 2017  MiMedx Group, Inc. (NASDAQ: MDXG), the leading ... processes to develop and market advanced products and therapies ... Ophthalmic, and Dental sectors of healthcare, today announced its ... ended December 31, 2016. Full Year 2016 ... 31% increase over full year 2015 revenue ...
Breaking Medicine Technology: