Navigation Links
Experimental Drug Shows Promise Against Cushing's Disease
Date:3/7/2012

WEDNESDAY, March 7 (HealthDay News) -- An experimental drug called pasireotide reduced levels of the "stress hormone" cortisol and improved symptoms in patients with Cushing's disease, a new study found.

Cushing's disease is a rare (three to five cases per million people) hormonal disorder that causes a wide range of health problems and, if untreated, significantly increases a patient's risk of dying at a much younger age than normal, researchers said in a news release.

Weight gain, high blood pressure, mood swings, irregular or absent menstrual periods, insulin resistance, glucose intolerance and type 2 diabetes are among the symptoms of Cushing's disease. It is a form of Cushing's syndrome, which is caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol.

This phase 3 study of 162 patients in 18 countries found that treatment with pasireotide reduced cortisol secretion by an average of 50 percent and returned some patient's cortisol levels to normal.

A phase 3 study means that a drug is in the final stages of testing that drugs undergo before they can be approved for treatment of a specific disease.

The study, funded by Novartis Pharma, appears in the March 8 issue of the New England Journal of Medicine.

Dr. Spyros Mezitis, an endocrinologist at Lenox Hill Hospital in New York City, is not associated with the study but is familiar with its findings.

Mezitis said the study showed that the experimental treatment "improved metabolic abnormalities and emotional difficulties. Therefore, pasireotide injections become an alternative to surgical resection of the pituitary ACTH-secreting tumor, and may be shown to work with the FDA-approved mifepristone, which blocks the action of cortisol at receptors in the body."

Elevated blood sugar (glucose) levels occurred in 73 percent of the patients who took the drug, a side effect that requires close attention, acc
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Experimental Drug Offers Hope for Rare Bone Disease: Study
2. Experimental Drug Shows Promise Against Type 2 Diabetes
3. First-in-human drug for malignant glioma available in experimental trial
4. Experimental Drug Might Beat Aspirin in Preventing Repeat Strokes: Study
5. Experimental Drugs Do Battle Against Advanced Prostate Cancer
6. Experimental Blood Thinner Given Before Surgery Shows Benefit
7. Wolfson Foundation awards £20 million to UCL for experimental neurology center
8. Novel experimental agent is highly active in CLL patients, interim study shows
9. Experimental Drug for Irregular Heart Rhythm Raises Death Risk: Study
10. Experimental Drug Slims Obese Monkeys
11. Experimental Psoriasis Drug Bests Older Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Drug Shows Promise Against Cushing's Disease
(Date:9/2/2014)... New research1 presented at the European Society of Cardiology ... of cardiovascular disease (CVD) is not enough to motivate ... data from 188,139 users of HeartAge.me, a free online ... factors as their estimated ,heart age, to test the ... CVD are more likely to attend medical examinations and ...
(Date:9/2/2014)... biochemists have discovered a family of proteins that could ... a pathogenic bacterium that can cause more than 60,000 ... of biochemistry and molecular biophysics, and Kasra Ramyar, his ... is the cause of increasing common staph infections. Their ... the National Academy of Sciences , or PNAS ...
(Date:9/2/2014)... News) -- Many people believe that marijuana is not ... "As more people are able to obtain and consume ... use, people are less likely to perceive it as ... at Massachusetts General Hospital,s Center for Addiction Medicine, said ... that cannabis use can have significant consequences, and we ...
(Date:9/2/2014)... 2014 Healthcare professionals will be able ... oncology guidelines available at the point of care following ... National Comprehensive Cancer Network® (NCCN®). Information from ... guidelines in the content available from the clinical reference ... not-for-profit alliance of 25 of the world's leading cancer ...
(Date:9/2/2014)... key to more youthful immune function might already be ... the Journal of Leukocyte Biology ... mice had different responses to Mycobacterium tuberculosis ... reversed by ibuprofen. , "Inflammation in old age can ... Ph.D., a researcher involved in the work from the ...
Breaking Medicine News(10 mins):Health News:Family history of cardiovascular disease is not enough to motivate people to follow healthy lifestyle 2Health News:Biochemists find new treatment options for staph infections, inflammatory diseases 2Health News:'Pot Addiction' May Be Real, Study Suggests 2Health News:DynaMed™ to Utilize Information from the National Comprehensive Cancer Network® 2Health News:DynaMed™ to Utilize Information from the National Comprehensive Cancer Network® 3Health News:DynaMed™ to Utilize Information from the National Comprehensive Cancer Network® 4
... Opus Healthcare Solutions, Inc., a ... today that OpusMobility(R) runs on ... ) , (Logo: http://www.newscom.com/cgi-bin/prnh/20080325/LATU040LOGO ) Opus ... or Wi-Fi connections on all smart phone devices ...
... January 13, 2009 A benchmarking study ... evaluated contemporary hospital glycemic management in United ... are suboptimal and do not meet current American ... The retrospective cohort study was based upon a ...
... its annual Molecular Imaging Summit to introducing the new ... Hilton Clearwater Hotel, Clearwater, Fl. In part, the program ... Network, which was designed to facilitate cost-effective drug development ... 2, 3 and 4 therapeutics clinical trials. In addition, ...
... health care policyWASHINGTON, Jan. 13 The RAND ... policymakers and interested parties with a unique way ... consequences of health care reform proposals certain to ... beyond. COMPARE (Comprehensive Assessment of Reform Efforts) is ...
... ATLANTA, Jan. 13 Vendormate nearly tripled its customer,base ... in 42 states across the,U.S. in part because of ... help mitigate the risk of supply chain,interruptions. , ... and financial service,providers in particular are anxious about their ...
... Family,Services, Inc. No. 2851 on its annual ranking of ... marks the second consecutive year that,Access Family Services has ... the most,comprehensive look at the most important segment of ... whole, these companies represent,the backbone of the U.S. economy. ...
Cached Medicine News:Health News:OpusMobility(R) Clinical Information System Runs on Google G1 Smart Phone 2Health News:OpusMobility(R) Clinical Information System Runs on Google G1 Smart Phone 3Health News:Annual SNM MI summit introduces the clinical trials network 2Health News:RAND Launches Unique Tool to Evaluate Health Care Proposals 2Health News:RAND Launches Unique Tool to Evaluate Health Care Proposals 3Health News:RAND Launches Unique Tool to Evaluate Health Care Proposals 4Health News:Economic Uncertainty Fuels Vendormate Growth in 2008 2Health News:Access Family Services, Inc. Makes the List for the Second Year in a Row! Access Family Services 2008 Ranks No. 2851 on the Inc. 5000 With Three-Year Sales Growth of 128% 2
(Date:9/2/2014)... 2014   Santa Clara dentist , Dr. ... for Invisalign. Invisalign is an orthodontic system that uses ... often the orthodontic treatment of choice for older teens ... it. For a limited time, patients can try Invisalign ... the usual cost. This offer cannot be combined, and ...
(Date:9/2/2014)... , Spanje, September 2, 2014 ... GARFIELD AF Registry bij het ESC CONGRESS ... bij patiënten met risico op beroerte in ... Gegevens van bijna 12.500 patiënten ingeschreven ... FIELD-Atrial Fibrillation (GARFIELD-AF), een innovatief, onafhankelijk initiatief ...
(Date:9/2/2014)... September 2, 2014 According to ... (Empty, Pre-packed, Analytical, Preparative), by Material (Metal, Glass, Plastic), ... TLC,SFC] - Forecast to 2018", published by MarketsandMarkets, the Chiral ... It is poised to grow at a CAGR of ... Browse 90 market data tables and ...
Breaking Medicine Technology:Santa Clara Cosmetic Dentist, Dr. Alan Frame, is Now Offering a Special on Invisalign 2Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 2Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 3Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 4Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 5Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 6Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 7Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 8Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 9Gegevens uit wereldwijde atriumfibrillatieregister tonen aan dat antistollingsmiddelen niet optimaal worden gebruikt ter preventie van beroerte 10Chiral Chromatography Column Market Worth $87.8 Million by 2018 2Chiral Chromatography Column Market Worth $87.8 Million by 2018 3Chiral Chromatography Column Market Worth $87.8 Million by 2018 4
... Oct. 29 , AT A GLANCE , ... PEM significantly improves ability to differentiate between benign ... MRI dramatically increased number of suspicious lesions found. ... women diagnosed with breast cancer found that Positron Emission ...
... Hospira, Inc. (NYSE: HSP ) celebrates the 25th anniversary ... 1984, Hospira,s PCA was the first pump of its kind, ... best when they are in pain, so allow them, within ... PCA technology has improved the safety and quality of care ...
Cached Medicine Technology:High-Resolution Breast PET Improves Breast Cancer Detection 2High-Resolution Breast PET Improves Breast Cancer Detection 3Healthcare Industry Celebrates 25 Years of Advanced Pain Management With PCA Infusion System 2Healthcare Industry Celebrates 25 Years of Advanced Pain Management With PCA Infusion System 3Healthcare Industry Celebrates 25 Years of Advanced Pain Management With PCA Infusion System 4
Colloidal Gold Conjugated, Rabbit anti-goat IgG (H&L) - 12 OD...
Polyester ribbons (3) impregnated with different OD values of conjugated Protein A...
Polyester ribbon impregnated with conjugated Protein A - .50 OD per sq. cm....
Colloidal Gold Conjugated, Protein A - 12 OD...
Medicine Products: