Navigation Links
Experimental Drug Seems to Aid Memory in Mice With Alzheimer's
Date:5/14/2013

TUESDAY, May 14 (HealthDay News) -- An experimental drug improved the memory and brain function in older mice with advanced symptoms of Alzheimer's disease, according to a new study.

Researchers from the Salk Institute in San Diego found that the drug, known as J147, increased levels of proteins that form the connections responsible for learning and memory, and reduced levels of a protein linked to cell death in the mice.

This explains how treating the mice with J147 led to an increase in factors that are necessary for correct memory function, according to the authors of the study, which was published online May 13 in the journal Alzheimer's Research & Therapy.

The effectiveness of J147 is the result of a new drug-discovery approach developed at the Salk Institute, said David Schubert, who heads the Cellular Neurobiology Laboratory.

"Our approach to screening drugs is very different from that currently used by pharmaceutical companies," Schubert said in a journal news release. "Alzheimer's disease is a complex disease associated with old age, and our goal is to make drugs like J147 that reduce the multiple toxicities associated with the disease, not just one.

"We believe that J147 is the best Alzheimer's disease drug candidate in the pipeline and will be effective if we can get it into the clinic," he added.

The researchers noted that separate studies found that J147 and another drug called donepezil (brand name Aricept) improved short-term memory and another form of memory commonly lost in Alzheimer's patients. They said that only J147 improved spatial memory, which relates to remembering information about places, such as knowing your way around your neighborhood.

Success in animal research is no guarantee of similar results in human research.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.

-- Mary Elizabeth Dallas

SOURCE: BioMed Central, news release, May 13, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Mayo Clinic finds experimental drug inhibits growth in all stages of common kidney cancer
2. Experimental Drug for Hepatitis C Promising, Studies Show
3. Experimental Vaccine Shows Promise for Ovarian Cancer
4. Cisplatin-resistant cancer cells sensitive to experimental anticancer drugs, PARP inhibitors
5. Experimental Staph Vaccine Fails to Work, Study Finds
6. Experimental Drug May Work Against Hepatitis C
7. Experimental Alzheimers Drug Shows Promise, Study Finds
8. Experimental Vitiligo Treatment Shows Promise in Mice
9. Harmful effects of bisphenol A proved experimentally
10. Experimental agent briefly eases depression rapidly in test
11. NIH-funded trial launched to assess experimental TB drug
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Drug Seems to Aid Memory in Mice With Alzheimer's
(Date:5/25/2016)... ... May 25, 2016 , ... ... seen a significant spike in their clients' employee participation for their wellness initiatives. ... screening by implementing a high-deductible health plan with outcome-based deductible incentives. As a ...
(Date:5/25/2016)... ... May 25, 2016 , ... Consumer access to organic foods and grower ... a maker of whole grain cereals and other plant-based foods, will introduce the first ... red winter wheat processed by Hesco/Dakota Organic Products. , The transitional designation means the ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... that it will join America's leading engineers at the American Society of Safety ... Georgia World Congress Center. , Engineers, speakers and exhibitors from more than ...
(Date:5/25/2016)... ... 25, 2016 , ... American Spine in Frederick, Maryland is ... surgeries in the Montgomery County, Howard County and Washington, D.C. areas, renowned spine ... American Spine every Monday. He will also perform surgeries in our Germantown surgical ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... Sterling Global ... feature a unique and patented refillable hanging wipe dispenser. The campaign kick-off video is ... and will end June 25, 2016. The goal is to raise $1,000 per day ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... , May 23, 2016 ... "Patient Handling Equipment Market by Product (Wheelchair, Scooters, ... Care (Bariatric Care, Critical Care, Wound), Accessories (Lifting, ... Forecast to 2021", published by MarketsandMarkets, the patient ... 17.18 Billion by 2021 at a CAGR of ...
(Date:5/23/2016)... Transparency Market Research has published ... Market - Global Industry Analysis, Size, Share, Growth, Trends, ... report, the exocrine pancreatic insufficiency market is anticipated to ... 2023 to reach US$2.85 Bn by 2023. ... the deficiency of the exocrine pancreatic enzymes, causing failure ...
(Date:5/23/2016)... , May 23, 2016 The World Health ... PrePex device to include adolescents aged 13 years, and ... can be offered for adult and adolescent males in the ... . PrePex was the first male circumcision device to ... MedTech,s CEO, Eddy Horowitz said: " The ...
Breaking Medicine Technology: