Navigation Links
Experimental Drug Fights Prostate Cancer
Date:11/7/2007

In mice, it attacked disease on multiple fronts, researchers say

WEDNESDAY, Nov. 7 (HealthDay News) -- In mice, an investigational agent called VN/14-1 proved effective in treating human prostate cancer, say researchers at the University of Maryland in Baltimore.

The five-week study found that daily injections of VN/14-1 in mice implanted with human prostate cancer cells resulted in up to a 50 percent reduction in tumor volume.

VN/14-1 blocks the breakdown of vitamin A-derived retinoic acid, the researchers explained. The drug appears to tackle cancer in multiple ways.

"This potent agent causes cancer cells to differentiate, forcing them to turn back to a non-cancerous state -- which is what we expected it would do -- but it also stops cancer growth by arresting the cell cycle and pushes cells to die by inducing programmed cell death," senior investigator Vincent C.O. Njar, associate professor in the department of pharmacology and experimental therapeutics in the School of Medicine, said in a prepared statement.

"These functions were unexpected and wonderfully surprising. I am not aware that any drug currently used to treat prostate cancer targets so many pathways," said Njar, whose lab developed VN/14-1.

The findings were to be presented Tuesday at an American Association for Cancer Research meeting.

Vitamin A is converted by the body into retinoic acid, which maintains the normal growth of cells. Prostate cancer cells contain five to eight times less retinoic acid than normal prostate cells. VN/14-1 is designed to block the breakdown of retinoic acid in cancer cells.

More information

The American Academy of Family Physicians outlines prostate cancer treatment options.



-- Robert Preidt
'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
2. Experimental Antidepressants Offer Faster Relief
3. Experimental drug shows promise in advanced kidney cancer
4. Experimental drug boosts survival in recurrent ovarian cancer
5. Experimental cancer pharmaceuticals under trial
6. Experimental Drug Fails Against Heart Failure
7. Guacamole: Fights Hunger, Cholesterol and Cancer
8. Two-Drug Combo Fights Brain Tumors
9. Connecticut Girl Fights Rare Neurological Disease
10. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... April 17, 2014 By discovering a new mechanism ... a stroke, researchers at UC Irvine and the Salk ... may limit or prevent stroke-induced brain damage. , A ... cause of death and primary reason for disability in ... a stroke and lets blood-borne material into the brain, ...
(Date:4/17/2014)... Alliance, a nonprofit organization that focuses on conservation and ... examining the current state of knowledge of the deadly ... global surveillance strategies to combat the emergence of infectious ... West Africa that has claimed the lives of 122 ... According to the World Health Organization (WHO), the deadly ...
(Date:4/17/2014)... to ward off depression among retirees, particularly among those ... The Journals of Gerontology, Series B: Psychological ... " Internet Use and Depression Among Retired Older Adults ... authors report that Internet use reduced the probability of ... sample. , Late-life depression affects between 5 and ...
(Date:4/17/2014)... NEW YORK (17 April 2014) Population Council scientists and ... is safe, stable, and can prevent the transmission of ... and rectum in animals: HIV, herpes simplex virus 2 ... provides the first data that the gel is effective ... of efficacy in the vagina against all three viruses ...
(Date:4/17/2014)... N.C. April 17, 2014 Meaningful long-term ... advanced cancer of the abdomen when treated with ... according to a first-of-its-size analysis by physicians at ... Baptist has the largest reported, single-center experience with ... A. Levine, M.D., and analysis of 20 years, ...
Breaking Medicine News(10 mins):Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3Health News:Internet use may cut retirees' depression 2Health News:Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum 2Health News:20 years of data shows treatment technique improvement for advanced abdominal cancer 2
... NEW YORK, Sept. 29 More and more ... them to maintain their quality of,life during difficult ... Philips (NYSE: PHG ) at:, http://media.medialink.com/WebNR.aspx?story=35774 ) ... drug delivery,technology designed to increase the effectiveness and ...
... it a “carrier of choice” for many in the medical device ... ... -- All medical devices share a critical need regardless of their ... the supply chain. For medical devices traveling to cross border ...
... With Federal matching funds included, long-term care costs ... link to the full report:, http://www.ahip.org/content/default.aspx?docid=24597 , ... $1.6 trillion on long-term care expenses over the ... today by America,s Health,Insurance Plans (AHIP). When Federal ...
... to Help Make More ,Cents, of,Grocery Bills, WASHINGTON, Sept. ... to join the famed Milk Mustache campaign, this time,to help ... are economizing on groceries but one thing they should not ... ounce glass, on a gallon,basis, milk offers more nutrients per ...
... Sept. 29 Open enrollment season,throughout corporate America ... will be making important decisions about their employee,benefit ... options will feature an,increased emphasis on personal health ... to new health services and programs, according to,benefit ...
... Releases Results of First ... ... of Health,Care Knowledge today released its first study: "Choosing a Health ... fact sheets and policy statements designed,to help create more informed consumers ...
Cached Medicine News:Health News:Medical Device Producers Express Interest in Purolator USA's Express Service and Customer Service 2Health News:State Medicaid Programs to Spend $1.6 Trillion on Long-Term Care over the Next Twenty Years 2Health News:State Medicaid Programs to Spend $1.6 Trillion on Long-Term Care over the Next Twenty Years 3Health News:Suze Orman Joins got milk? Milk Mustache Campaign: New Ad Encourages Families To Invest in Milk's Nutritional Assets 2Health News:Suze Orman Joins got milk? Milk Mustache Campaign: New Ad Encourages Families To Invest in Milk's Nutritional Assets 3Health News:Watson Wyatt Identifies Trends for Benefits Open Enrollment Season 2Health News:Watson Wyatt Identifies Trends for Benefits Open Enrollment Season 3Health News:Access to Physicians Is Consumers' Highest Priority When Choosing a Health Plan, According to New Study 2Health News:Access to Physicians Is Consumers' Highest Priority When Choosing a Health Plan, According to New Study 3
(Date:1/15/2014)...  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the ... Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ) ... in order to treat dental impairments, for tooth restoration ...
(Date:1/15/2014)... WASHINGTON , Jan. 15, 2014 AARP Foundation today ... support older adults suffering from the severe cold weather that ... are committed to helping those in need; so to support ... dollar-for-dollar contributions up to $250,000, which could mean up to ...
(Date:1/15/2014)... , Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... commitments from institutional investors to purchase an aggregate of ... an at-the-market registered direct offering, led by a dedicated ... definitive purchase agreements with these investors pursuant to which ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... CHADDS FORD, Pa., July 10 ... Pharmaceuticals (Nasdaq: ENDP ) jointly announced today that ... and market Urocidin(TM) in the U.S. with an option for ... Mycobacterial Cell Wall-DNA Complex (MCC) developed by Bioniche for the ...
... , ALEXANDRIA, Va., July 9 The world-wide explosion of ... of obesity is widely recognized. Could it really be an ... over the increasing prevalence of overweight conditions in our society, ... as a potential direct contributor to obesity. , ...
Cached Medicine Technology:Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM) 2Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM) 3Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM) 4Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM) 5Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM) 6Is Obesity an Oral Bacterial Disease? 2
... Magnetom Sonata is a system of unparalleled ... and for cardiovascular and neuroradiological applications. Magnetom ... previously stored optimized sequences, clinical flexibility, and ... fastest MR system in the industry for ...
Inside and out, the Achieva is designed to unleash a new era, in which the clinical capabilities of MR will further expand....
... Symphony Platelet Concentrate System is a point-of-care ... Platelet Concentrate (also referred to as Platelet ... Plasma (PPP) from a small sample of ... natural growth factors, which are found in ...
... extensive base of experience and knowledge in ... concentrated autologous platelets are mixed with calcified ... changes involved in coagulation take place. Secreted ... factors including serotonin, fibronectin, adenosine diphosphate, thromboxane ...
Medicine Products: