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Experimental Dengue Vaccine Shows Some Success
Date:9/11/2012

up. This was not a statistically significant difference.

However, secondary tests revealed the vaccine was effective in protecting against three of the viruses that cause dengue, DENV 1, 3 and 4, the researchers say. The virus DENV 2 was resistant to the vaccine. None of the children who received the vaccine suffered serious side effects, according to the report.

Although the trial was limited to Thailand, the researchers say their findings advance the development of a dengue vaccine.

"Our study constitutes the first-ever demonstration that a safe and effective dengue vaccine is possible," Wallace said. "Further trials of CYD-TDV are currently under way in a number of different countries, and our hope is that the positive results of this trial will be confirmed by these larger studies, taking place in a wide range of epidemiological settings."

Developing a vaccine for dengue has been slowed by the fact that it is caused by four different viruses, the release noted. Moreover, because dengue is also believed to be unique to humans, scientists cannot test the vaccine on animal models.

In an accompanying journal commentary, Dr. Scott Halstead, of the International Vaccine Institute in Seoul, South Korea, said that future dengue vaccine trials should determine if the vaccine is effective against severe and mild forms of the disease.

More information

The U.S. Centers for Disease Control and Prevention has more about dengue.

-- Mary Elizabeth Dallas

SOURCE: The Lancet, news release, Sept. 10, 2012


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