Navigation Links
Experimental Chemo Combo for Colon Cancer Disappoints

TUESDAY, April 3 (HealthDay News) -- Adding the drug cetuximab (brand name Erbitux) to standard chemotherapy after surgery for stage 3 colon cancer did not improve disease-free survival in patients, a new study concludes.

Patients with stage 3 colon cancer who undergo surgery have a 50 percent chance of cure, and clinical trials have found that chemotherapy with the drugs leucovorin, fluorouracil and oxaliplatin (a regimen known as FOLFOX) after surgery can cut the odds for colon cancer's return.

Staging refers to the severity of cancer. A stage 3 cancer has spread nearby, while a stage 4 cancer has spread to another organ.

This study of almost 2,700 patients investigated the addition of cetuximab to the FOLFOX regimen and found that it provided no extra benefit.

Three-year disease-free survival for patients who received the FOLFOX regimen alone ranged from 67 percent to 75 percent, compared with 65 percent to 72 percent for those who also received cetuximab, the study found.

The study appears in the April 4 issue of the Journal of the American Medical Association.

The time to cancer recurrence and overall survival was similar in both groups, said Dr. Steven Alberts, of the Mayo Clinic in Rochester, Minn., and colleagues in a journal news release.

It's not clear why the addition of cetuximab to the FOLFOX regimen did not benefit patients, the researchers noted.

Dr. Richard Whelan, chief of colorectal surgery at St. Luke's-Roosevelt Hospital in New York City, explained that the drug had shown promise with other patients.

"Cetuximab was added to the FOLFOX regimen based on promising results noted when this agent was given to stage 4 colon cancer patients either alone or with other chemotherapy agents," said Whelan, who was not involved in the new study. "Unfortunately, what works in one setting may not prove equally effective in a different population of patients. Researchers will continue to search for new drug combinations that are more effective than the present regimens."

Cetuximab still has a role in the treatment of certain patients with stage 4 cancer, Whelan said.

And another expert said that, even though the drug failed to help these patients, important lessons have still been learned.

"Although this is a negative study, there is a benefit to patient care," said Dr. David Bernstein, chief, division of gastroenterology at North Shore University Hospital in Manhasset, N.Y. "The increased toxicity [side effects] seen with the addition of cetuximab did not translate into increased survival, and therefore this drug can be removed from the treatment cocktail without sacrificing outcome, and by its removal, lessen patient adverse events on therapy."

More information

The U.S. National Cancer Institute has more about colon cancer treatment.

-- Robert Preidt

SOURCES: Richard Whelan, M.D., chief of colorectal surgery, St. Luke's-Roosevelt Hospital, New York City; David Bernstein, M.D., chief, division of gastroenterology, North Shore University Hospital, Manhasset, N.Y.; Journal of the American Medical Association, news release, April 3, 2012

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental Pill May Ease Multiple Sclerosis Disability
2. Experimental Drug Shows Promise Against Cushings Disease
3. Experimental Drug Offers Hope for Rare Bone Disease: Study
4. Experimental Drug Shows Promise Against Type 2 Diabetes
5. First-in-human drug for malignant glioma available in experimental trial
6. Experimental Drug Might Beat Aspirin in Preventing Repeat Strokes: Study
7. Experimental Drugs Do Battle Against Advanced Prostate Cancer
8. Experimental Blood Thinner Given Before Surgery Shows Benefit
9. Wolfson Foundation awards £20 million to UCL for experimental neurology center
10. Novel experimental agent is highly active in CLL patients, interim study shows
11. Experimental Drug for Irregular Heart Rhythm Raises Death Risk: Study
Post Your Comments:
Related Image:
Experimental Chemo Combo for Colon Cancer Disappoints
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: , ... to enable prevention of a major side effect of chemotherapy in children. Cisplatin ... patients. For cisplatin, hearing loss is FDA listed on-label as a dose limiting ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will join ... International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey Dome, ... at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division of ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... (HLA), the nation's first interactive health literacy software tool, and the Cancer Patient ... aspects of cancer patient education, today announce a new strategic alliance. , ...
(Date:10/12/2017)... ... October 12, 2017 , ... Farm ... California Berkeley, and other leading institutions in announcing the launch of the ... change the way animals are raised for food. , Founding members of the ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  BioPharmX Corporation (NYSE MKT: BPMX) researchers were ... innovative way to use nonlinear optical imaging to confirm ... drugs. A ... show how researchers from BioPharmX and the Wellman Center ... a suite of imaging techniques in what is called ...
(Date:10/10/2017)... Calif. , Oct. 10, 2017  NDS received FDA 510(k) ... — a medical-grade battery-powered display stand specifically designed for endoscopy environments. ... transform technology into a clinical solution to support the improvement of ... Innovative Design ... Mobile Wireless Solution ...
(Date:10/4/2017)... Oct. 4, 2017  South Korean-based healthcare product Development ... aide "cprCUBE" on Kickstarter. The device will educate the ... arrests with better efficiency compared to the dated and ... feedback on efficacy of the compression for a more ... a goal to raise $5,000. ...
Breaking Medicine Technology: