Navigation Links
Experimental Blood Thinner Given Before Surgery Shows Benefit
Date:1/17/2012

TUESDAY, Jan. 17 (HealthDay News) -- An experimental anti-blood-clotting drug can serve as a replacement for other drugs such as Plavix in the days before heart surgery, a new study has found.

The intravenous drug cangrelor appears to have the potential to serve as a "bridge" medication for heart patients to take in the several days before procedures such as coronary artery bypass grafting, the study authors reported.

Anti-clotting drugs, also referred to as antiplatelet therapy or anticoagulants -- including clopidogrel, known by the brand name Plavix -- are often given to heart patients to prevent dangerous vessel-clogging blood clots. But they can cause too much bleeding during surgery, and guidelines suggest that doctors stop treatment with them in the five to seven days before an operation.

In the new study, Dr. Dominick Angiolillo of the University of Florida, Jacksonville, and colleagues gave cangrelor or a placebo to 210 patients who were about to undergo coronary artery bypass grafting. The patients had been treated with a thienopyridine (such as Plavix) but went off the drugs prior to surgery as recommended, then received cangrelor or placebo for at least 48 hours until one to six hours before surgery.

Angiolillo's team found that excessive bleeding related to surgery wasn't much more likely in the patients who took the drug (11.8 percent) compared to those who took the placebo (10.4 percent). Major bleeding problems before surgery were rare, while those who took cangrelor had more minor bleeding problems, according to the report published in the Jan. 18 issue of the Journal of the American Medical Association.

The investigators also found that the patients who took cangrelor reached levels of platelet inhibition that are linked to a lower risk of problems such as clots.

The findings make sense, said Dr. Gregg Stone, a heart specialist and professor of medicine at Columbia University in New York City. The study shows that cangrelor works rapidly and then dissipates when it isn't needed anymore so it doesn't boost the risk of bleeding during surgery, he said.

"This drug is investigational, so it is not yet an option for patients to ask about," Stone pointed out, "but if [the U.S. Food and Drug Administration] approved it, it would likely be widely used."

More information

For more about blood thinners, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: Gregg W. Stone, M.D., professor, medicine, Columbia University, New York City; Jan. 18, 2012, Journal of the American Medical Association


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Wolfson Foundation awards £20 million to UCL for experimental neurology center
2. Novel experimental agent is highly active in CLL patients, interim study shows
3. Experimental Drug for Irregular Heart Rhythm Raises Death Risk: Study
4. Experimental Drug Slims Obese Monkeys
5. Experimental Psoriasis Drug Bests Older Treatment
6. Experimental Vaccine Shows Promise for Lung Cancer: Study
7. Experimental vaccine protects monkeys from blinding trachoma
8. Experimental MS Drug Shows Promise
9. Researchers create new experimental vaccine against chikungunya virus
10. Experimental Drug Promising Against Tough-to-Treat Asthma
11. University Hospitals Case Medical Center to begin clinical trial on experimental anti-TB drug
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Blood Thinner Given Before Surgery Shows Benefit  
(Date:5/1/2016)... ... 01, 2016 , ... ProBrand Reveal Volume 2 is a set of versatile and smooth logo ... keyframeless animations, users can easily create a unique logo reveal in just a matter of ... presets. Use these title presets to add a uniquely animated logo to any photos or ...
(Date:4/30/2016)... ... April 30, 2016 , ... ... Radio with Hypnotherapist, Mary O'Maley. What is hypnosis and hypnotherapy and why ... smoking, weight control), pain relief (chronic and acute), birthing processes and medical procedures, ...
(Date:4/30/2016)... ... , ... well is a challenge for all of us, but there are things we can do to ... “Research is showing more and more that there are simple, yet important steps that can ... age.” Top priorities Dr. Kohli’s recommends for her patients include;, , exercise ...
(Date:4/29/2016)... ... April 29, 2016 , ... Since launching its annual volunteer ... serving the footwear industry, has broken all previous participation records in its first ... 23 states during the months of April and May, the 2016 Footwear Cares ...
(Date:4/29/2016)... ... 29, 2016 , ... The American workforce is on everyone’s ... Most importantly, employees are the single most important asset in creating value and ... , Just under half of American workers are emotionally checked out with low ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... , Schweiz, April 27, 2016 /PRNewswire/ ... des Sachs CEO Forums in Zürich gab ... ihres führenden Wirkstoffkandidaten STR001 zur Erhaltung des ... eingesetzt wurde, bekannt. Für die umfassende Phase-II-Doppelblindstudie ... und Frankreich angeworben. STR001 wird während der ...
(Date:4/27/2016)...   , Total Sales Grow ... Clinical sales grow 16% year-over-year  , ... MKEAY) inventor of Cellvizio®, the multidisciplinary confocal laser endomicroscopy ... ended March 31, 2016 and provided an update on ... First Quarter 2016 Revenue Results by Category  ...
(Date:4/27/2016)... April 27, 2016 Transparency Market ... Devices Market - Global Industry Analysis, Size, Share, Growth, ... report, the global skincare devices market was valued at ... expand at a CAGR of 10.1% from 2015 to ... Browse the full Skincare Devices Market (Treatment Device - ...
Breaking Medicine Technology: