Navigation Links
Experimental Blood Thinner Given Before Surgery Shows Benefit
Date:1/17/2012

TUESDAY, Jan. 17 (HealthDay News) -- An experimental anti-blood-clotting drug can serve as a replacement for other drugs such as Plavix in the days before heart surgery, a new study has found.

The intravenous drug cangrelor appears to have the potential to serve as a "bridge" medication for heart patients to take in the several days before procedures such as coronary artery bypass grafting, the study authors reported.

Anti-clotting drugs, also referred to as antiplatelet therapy or anticoagulants -- including clopidogrel, known by the brand name Plavix -- are often given to heart patients to prevent dangerous vessel-clogging blood clots. But they can cause too much bleeding during surgery, and guidelines suggest that doctors stop treatment with them in the five to seven days before an operation.

In the new study, Dr. Dominick Angiolillo of the University of Florida, Jacksonville, and colleagues gave cangrelor or a placebo to 210 patients who were about to undergo coronary artery bypass grafting. The patients had been treated with a thienopyridine (such as Plavix) but went off the drugs prior to surgery as recommended, then received cangrelor or placebo for at least 48 hours until one to six hours before surgery.

Angiolillo's team found that excessive bleeding related to surgery wasn't much more likely in the patients who took the drug (11.8 percent) compared to those who took the placebo (10.4 percent). Major bleeding problems before surgery were rare, while those who took cangrelor had more minor bleeding problems, according to the report published in the Jan. 18 issue of the Journal of the American Medical Association.

The investigators also found that the patients who took cangrelor reached levels of platelet inhibition that are linked to a lower risk of problems such as clots.

The findings make sense, said Dr. Gregg Stone, a heart specialist and professor of medicine at Columbia University in New York City. The study shows that cangrelor works rapidly and then dissipates when it isn't needed anymore so it doesn't boost the risk of bleeding during surgery, he said.

"This drug is investigational, so it is not yet an option for patients to ask about," Stone pointed out, "but if [the U.S. Food and Drug Administration] approved it, it would likely be widely used."

More information

For more about blood thinners, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: Gregg W. Stone, M.D., professor, medicine, Columbia University, New York City; Jan. 18, 2012, Journal of the American Medical Association


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Wolfson Foundation awards £20 million to UCL for experimental neurology center
2. Novel experimental agent is highly active in CLL patients, interim study shows
3. Experimental Drug for Irregular Heart Rhythm Raises Death Risk: Study
4. Experimental Drug Slims Obese Monkeys
5. Experimental Psoriasis Drug Bests Older Treatment
6. Experimental Vaccine Shows Promise for Lung Cancer: Study
7. Experimental vaccine protects monkeys from blinding trachoma
8. Experimental MS Drug Shows Promise
9. Researchers create new experimental vaccine against chikungunya virus
10. Experimental Drug Promising Against Tough-to-Treat Asthma
11. University Hospitals Case Medical Center to begin clinical trial on experimental anti-TB drug
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Blood Thinner Given Before Surgery Shows Benefit  
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. ... with persons with autism and other developmental disabilities, as well as supporting staff ... education, adolescents with autism, school consultation, and staff development. She joined the company ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst ... Mandeville was named an Entrepreneur Of The Year® 2020 Florida Award finalist. Now ... leaders whose ambitions deliver innovation, growth and prosperity as they build and sustain ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... set out to continue helping the specialty-diet community connect with great, gluten-free ... products, get coupons, enter giveaways, chat with brands & watch over 50 educational ...
(Date:8/28/2020)... ... August 28, 2020 , ... A July 27 ... obese individuals are at an increased risk of developing severe COVID-19 symptoms. The ... COVID-19; however, because the same organ systems that the coronavirus attacks are already ...
(Date:8/27/2020)... , ... August 27, 2020 , ... ... partner with Evolution Labs to provide their students with Suite360:Mental Health and Prevention, ... Mental Health, Substance Abuse and Child Trafficking Prevention. , Florida schools and districts ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... 2020 , ... Continuing on its rapid national expansion - ... deodorization provider - is proud to announce it has opened doors in Phoenix, ... residents throughout the area. , Germinator provides a 100% safe and non-toxic sanitizing ...
(Date:8/28/2020)... ... ... Dr. Mark Surrey has been in practice for over 25 years. He ... the Department of OBGYN at UCLA’s David Geffen School of Medicine. , He ... is a Clinical Director of Fellowship Training for UCLA & Cedars Sinai Reproductive Endocrinology. ...
(Date:8/27/2020)... AUSTIN, Texas (PRWEB) , ... August 27, 2020 , ... ... Central Texas – is pleased to announce Dr. David Szalay, DDS, MD, has joined ... to treat patients in the new Pflugerville office, which is scheduled to open this ...
Breaking Medicine Technology: