Navigation Links
Experimental Blood Substitutes Unsafe, Study Finds
Date:4/28/2008

>The problem with such products is that "these hemoglobins do not have the protection of red blood cells," said study co-author Dr. Sidney Wolfe, director of the health research group at Washington, D.C.-based Public Citizen, an advocacy group that is often at odds with government agencies.

"Outside the cell, hemoglobin scavenges nitric oxide," Wolfe explained. "This causes constriction of arteries that is predictive of increased risk of heart attacks and organ damage."

Wolfe and Public Citizen initiated the inquiries that produced the report, starting in 2006. "We learned from the Federal Register that the FDA would hold an advisory committee meeting about a blood product," Wolfe said. "They decided to keep it secret. We sued the FDA, and they canceled the meeting because it was illegal."

Wolfe contacted Natanson, "because I knew he was on advisory committee of the FDA," and they began a search for information on hemoglobin-based blood substitutes. It was not easy to find, because neither the companies testing the products nor the FDA were forthcoming with information, Wolfe charged. Often, the FDA did not report on trial results, because they were regarded as trade secrets, he said.

The only information available in many cases came from press releases. In the case of one product, Polyheme, a report was not published until December, 2006, six years after the trial ended.

"It took a long amount of time, because a meta-analysis like this, if done appropriately, takes an enormous amount of energy and time," Natanson said.

The FDA itself did not do the kind of meta-analysis that produced the journal report, Wolfe said, but the evidence that the products caused harm should have been evident by the year 2000, he said.

"In the eight countries where there are clinical trials, if they had been aware of the cumulative picture, they would not have allowed the trials to go forward," he said.

The FD
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Honda to Showcase Experimental Walking Assist Device
2. Experimental Alzheimers Drug Shows Promise
3. Experimental drug shows promise in treating certain lymphomas
4. Experimental Cancer Vaccines Show Promise
5. Gourmetceuticals Presents Findings on Science You Can Eat at Experimental Biology 2008
6. Cavities in Children Reduced Over 60 Percent by New Experimental Chewable Mints
7. Gourmetceuticals to Present Data from Four Studies at Experimental Biology 2008
8. 52 minority scientists receive travel fellowships to Experimental Biology 2008
9. Experimental Biology 2008 Todays Research: Tomorrows Health, April 5-9
10. Experimental Vaccine Halts Prostate Cancer in Mice
11. Experimental technique at GUMC offers real-time analysis of breast cancer biopsies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Blood Substitutes Unsafe, Study Finds
(Date:7/12/2014)... With prom shopping reaching its final days, ... ready to showcase its new and trendy apparels. Recently, ... dresses in its online shop. Additionally, it is now ... elegant gowns. According to the company’s sales manager, the ... 2014. , He says, “Now, worldwide clients can ...
(Date:7/12/2014)... Wright & Schulte LLC has filed a ... subsidiary of Johnson & Johnson, on behalf of an Ohio ... a metal-on-metal DePuy Pinnacle hip replacement and had to undergo ... implant. The DePuy hip lawsuit was filed July 7, 2014, ... No. 3:14-cv-2427) where DePuy Pinnacle Hip lawsuit litigation is ...
(Date:7/12/2014)... 2014 Doylestown Hospital recently conducted an ... men’s health questions. Paddock tackles topics including main ... women live longer than men, and testosterone replacement therapy, ... Simple featured on Doylestown Hospital’s website, Dr. Brad ... any age. If you notice pain, bulging, or asymmetry ...
(Date:7/12/2014)... Utah Valley Entrepreneurial Forum Top 25 ... being bestowed to companies in revenue, and pre-revenue startups. ... with recognition for new ideas as well as companies ... , 25 Under 5 highlights outstanding Utah entrepreneurs and ... 5 years old. Award recipients were recognized at their ...
(Date:7/12/2014)... July 12, 2014 A recent article released ... a trio of suggestions for those seeking cosmetic surgical ... are rapidly approaching and the heat begins to enliven the ... their summer clothing, realizing that they didn’t work out as ... This can cause a sudden surge of people eager to ...
Breaking Medicine News(10 mins):Health News:VogueQueen.com Updates Its Summer Collection With New And Trendy Evening Dresses 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 5Health News:Ivyland Medical Center’s Dr. Brad Paddock Offers Tips for Men’s Health 2Health News:SquareHook is Recognized for UVEF 25 Businesses Under 5 Years-Watch Out 2Health News:Best Summer Cosmetic Surgeries Revealed in Article By Seattle Plastic Surgeon 2
... becoming more prevalent in that setting, study finds , ... infections are becoming more common among children in hospital ... they,re admitted and weekly thereafter, a new study suggests. ... children admitted to the pediatric ICU unit at the ...
... ,outrageous, misdeeds on Grey,s Anatomy , House ... in Seattle, a doctor overly involved with a patient attempted ... on the list of people eligible for an organ transplant. ... the incident was completely fictitious, having been an episode in ...
... ... In-Vitro Fertilization Experiences at MomAtLast.com , ... (PRWEB) March 31, 2010 -- Phenomenal moms-helping-moms-to-be website MomAtLast.com announces a ... MomAtLast.com has become a great resource for women of all ages who are trying ...
... ... Your Own Price" Membership Program for His Brooklyn-Based Fitness Boot Camp; Believing that Hard ... Additionally, Captain Quinn will Match 20% of all Commitments Above a Monthly Target Amount ... ...
... Mattress ... , ... March 31, 2010 -- Mattress Warehouse is pleased to announce its new Serta mattress ... Vera Wang by Serta and introducing Perfect Dreamer, the website offers all of these ...
... ... Medical Center (Pittsburgh, Pa.) and Blount Memorial Hospital (Knoxville, Tenn.) are the first ... errors and enables nurses and doctors to better coordinate care. , ... Knoxville, TN (PRWEB) ...
Cached Medicine News:Health News:Children in Intensive Care Should Be Screened for MRSA 2Health News:TV Doctors Bring Unethical Behavior to Prime Time 2Health News:TV Doctors Bring Unethical Behavior to Prime Time 3Health News:Share the Story Of How You Became a 'Mom At Last' And Win $100 2Health News:Brooklyn Fitness Boot Camp Fights Recession, Improves Lives and Supports Community with "Service First: Fitness at Any Price" Business Model 2Health News:Mattress Warehouse Announces its New Serta Mattress Lineup 2Health News:New PerfectServe Clinician-to-Clinician Communications System Gives Physicians Control and Helps Hospitals Coordinate Care 2Health News:New PerfectServe Clinician-to-Clinician Communications System Gives Physicians Control and Helps Hospitals Coordinate Care 3Health News:New PerfectServe Clinician-to-Clinician Communications System Gives Physicians Control and Helps Hospitals Coordinate Care 4
(Date:7/11/2014)... ST. LOUIS , July 11, 2014 ... medical device company, announced today the positive, ... of its innovative SPiNPerc™ procedure. The SPiNPerc ... use of a percutaneous approach to biopsy ... possible.  Hospitals, patients and physicians experience positive ...
(Date:7/10/2014)...  The U.S. Department of Health and Human Services ... (UH) Case Medical Center Seidman Cancer Center totaling $4.7 ... improving care for patients with complex cancer. ... a unique model developed at UH to enhance care ... or demonstrated need for high health care utilization.  ...
(Date:7/10/2014)... , July 10, 2014  BC Technical, the largest ... MiE America , Inc., a leading provider of Siemens ... a long-term agreement naming BC Technical as the authorized ... MiE and BC Technical announced today that ... establish BC Technical as the service and systems provider ...
Breaking Medicine Technology:Veran Medical Publishes Lung Cancer Patient Management Study 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2
... Inc. (Nasdaq: SVNT ) today announced that its ... by the U.S. Food and Drug Administration (FDA), a strategic ... in a sale of the Company at this time. The ... to the Company to maximize value. The ...
... HATBORO, Pa., Oct. 25 InfoLogix, Inc. ... provider of enterprise mobility solutions for the healthcare and ... at the South Florida Healthcare Trade Faire and Regional ... October 28, 2010 at the Signature Grand Hotel in ...
Cached Medicine Technology:Savient Pharmaceuticals Provides Update on Strategic Alternatives Process 2Savient Pharmaceuticals Provides Update on Strategic Alternatives Process 3InfoLogix to Present at South Florida Healthcare Trade Faire & Regional Conference 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: