Navigation Links
Experimental Blood Substitutes Unsafe, Study Finds
Date:4/28/2008

>The problem with such products is that "these hemoglobins do not have the protection of red blood cells," said study co-author Dr. Sidney Wolfe, director of the health research group at Washington, D.C.-based Public Citizen, an advocacy group that is often at odds with government agencies.

"Outside the cell, hemoglobin scavenges nitric oxide," Wolfe explained. "This causes constriction of arteries that is predictive of increased risk of heart attacks and organ damage."

Wolfe and Public Citizen initiated the inquiries that produced the report, starting in 2006. "We learned from the Federal Register that the FDA would hold an advisory committee meeting about a blood product," Wolfe said. "They decided to keep it secret. We sued the FDA, and they canceled the meeting because it was illegal."

Wolfe contacted Natanson, "because I knew he was on advisory committee of the FDA," and they began a search for information on hemoglobin-based blood substitutes. It was not easy to find, because neither the companies testing the products nor the FDA were forthcoming with information, Wolfe charged. Often, the FDA did not report on trial results, because they were regarded as trade secrets, he said.

The only information available in many cases came from press releases. In the case of one product, Polyheme, a report was not published until December, 2006, six years after the trial ended.

"It took a long amount of time, because a meta-analysis like this, if done appropriately, takes an enormous amount of energy and time," Natanson said.

The FDA itself did not do the kind of meta-analysis that produced the journal report, Wolfe said, but the evidence that the products caused harm should have been evident by the year 2000, he said.

"In the eight countries where there are clinical trials, if they had been aware of the cumulative picture, they would not have allowed the trials to go forward," he said.

The FD
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Honda to Showcase Experimental Walking Assist Device
2. Experimental Alzheimers Drug Shows Promise
3. Experimental drug shows promise in treating certain lymphomas
4. Experimental Cancer Vaccines Show Promise
5. Gourmetceuticals Presents Findings on Science You Can Eat at Experimental Biology 2008
6. Cavities in Children Reduced Over 60 Percent by New Experimental Chewable Mints
7. Gourmetceuticals to Present Data from Four Studies at Experimental Biology 2008
8. 52 minority scientists receive travel fellowships to Experimental Biology 2008
9. Experimental Biology 2008 Todays Research: Tomorrows Health, April 5-9
10. Experimental Vaccine Halts Prostate Cancer in Mice
11. Experimental technique at GUMC offers real-time analysis of breast cancer biopsies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experimental Blood Substitutes Unsafe, Study Finds
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... funeral mounds, mummification, belief in life after death ... "odd" or even terrifying by another., The Greeks, for ... the ancient Issedonians chopping up their dead into a ... something entirely contrary to the Greeks, treatment of their ...
... use of cells from embryos , , WEDNESDAY, Oct. 8 ... how to coax sperm-producing testicular cells into embryonic-like stem ... flurry of published research that seeks to duplicate embryonic ... and ethical obstacles associated with their use. , "The ...
... Oct. 8 The National,Community Pharmacists Association (NCPA) ... representing North Carolina, for re-election,to the U.S. Senate. ... of,NCPA, issued the following statement:, "Senator Elizabeth ... and,America,s community pharmacies and the patients they serve. ...
... ALEXANDRIA, Va., Oct. 8 The National,Community Pharmacists ... one-term incumbent representing Arkansas, for re-election to the,U.S. ... CEO of NCPA,issued the following statement:, "Senator ... and America,s,community pharmacies and the patients they serve. ...
... Va., Oct. 8 The National,Community Pharmacists Association ... incumbent representing Kansas, for re-election to the,U.S. Senate. ... of NCPA,issued the following statement:, "Senator Pat ... America,s,community pharmacies and the patients they serve. That ...
... to stressful events or something more? Learn more at,National ... 8 With the crisis on Wall,Street, a boom ... the country, no one can blame you for feeling ... to be angry,worried and even gloomy, especially if you ...
Cached Medicine News:Health News:Deathways open doors to unexpected cultural practices 2Health News:Researchers Create Embryonic-Like Stem Cells From Human Testes 2Health News:Researchers Create Embryonic-Like Stem Cells From Human Testes 3Health News:Researchers Create Embryonic-Like Stem Cells From Human Testes 4Health News:Economic Crisis Making You Anxious or Depressed? 2Health News:Economic Crisis Making You Anxious or Depressed? 3
(Date:12/24/2014)... , Dec. 24, 2014  Actavis plc (NYSE: ... Company has received a complete response letter from ... its New Drug Application (NDA) for the fixed-dose ... treatment of hypertension.   Photo - ... disappointed in the receipt of a complete response ...
(Date:12/24/2014)... /PRNewswire/  -- Tianyin Pharmaceutical Inc. (NYSE Amex: ... in the patented biopharmaceutical, modernized traditional Chinese medicine ... released unaudited preliminary financial results for the first ... Year 2015 Ended September 30, 2014 Financial Highlights: ... $14.7 million in 1Q14 with gross margins improved ...
(Date:12/24/2014)... 2014 Soligenix, Inc. (OTCQB: SNGX) (Soligenix ... products that address unmet medical needs in the ... that on December 24, 2014 it closed its ... Company raised approximately $2.3 million in gross proceeds ... net proceeds from the offering to fund its ...
Breaking Medicine Technology:Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 2Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 3Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 2TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 3TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 5TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 6TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 7TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 8TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 9TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 10TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 11TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 12Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3
... VANCOUVER, April 26, 2007,/PRNewswire-FirstCall/ - Angiotech Pharmaceuticals, ... device company, announced that,the two-year data from ... Paclitaxel-Eluting Mesh ("Vascular Wrap(TM)"),will be presented today ... study examined the safety and efficacy of ...
... 26, 2007 /PRNewswire-FirstCall/ --,Australian drug development company ... randomised Phase II clinical,trial in patients with ... compared to irinotecan which is,considered to be ... colorectal,cancer. This announcement is being made at ...
Cached Medicine Technology:Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 2Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 3Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 4Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 5Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 6Two-year data for Angiotech's Vascular Wrap Paclitaxel-Eluting Mesh,to be Presented at European Vascular Symposium 7Alchemia Reports Preliminary Positive Efficacy Data From HyCAMP,Phase II Trial 2Alchemia Reports Preliminary Positive Efficacy Data From HyCAMP,Phase II Trial 3Alchemia Reports Preliminary Positive Efficacy Data From HyCAMP,Phase II Trial 4Alchemia Reports Preliminary Positive Efficacy Data From HyCAMP,Phase II Trial 5Alchemia Reports Preliminary Positive Efficacy Data From HyCAMP,Phase II Trial 6Alchemia Reports Preliminary Positive Efficacy Data From HyCAMP,Phase II Trial 7
... This BioSafe room is configured specifically ... and chemical analysis. Panels are precision-joined ... easy to wipe down and disinfect. ... double-wall panel design creates strong, rigid ...
... Features hardwall acrylic panels ... frame to form a free-standing ... to Class 10/ISO 3. Optional ... and ionizers are configured to ...
... curtains or parting strip shields ... frame to form a free-standing, ... cleanliness to Class 10/ISO 3. ... lights, and ionizers are configured ...
... cleanroom for biological safety labs (BSL) ... (to Class 10/ISO 3) and easy ... ultra-smooth surfaces that are easy to ... corners simplify cleaning. Unique double-wall panel ...
Medicine Products: