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Experimental Antidepressants Offer Faster Relief
Date:9/5/2007

effect.

"SSRIs interfere with the serotonin system and increase naturally transmitted serotonin to help the system readjust itself," Frye explained. "The new drugs act only on one receptor. They're more selective."

For the study, the researchers tested two serotonin receptor agonist compounds, called RS 67333 and prucalopride, in rats, comparing the drugs against the action of Celexa. Using different measures of depression, the researchers found that the two new drugs acted four to seven times faster and also seemed more powerful.

In one test, the researchers found that one of the serotonin receptor agonists took effect after only three days and completely erased the depressive symptoms after one week.

For instance, mild stress has been shown to reduce consumption of sugar water by rodents -- a behavior alleviated by weeks of SSRI treatment. But the McGill researchers found that one of the serotonin receptor agonists produced effects within three days and seemed to removed the depressive symptoms within a week.

The new drugs, however, may have side effects. "There are potential side effects, and that's where the rub could be with clinical trials," Frye said.

More information

For more on depression, visit the U.S. National Institute of Mental Health.



SOURCES: Gerald Frye, Ph.D., Joseph H. Shelton Professor of Neuropharmacology and Neurotoxicology, Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center College of Medicine; Sept. 6, 2007, Neuron


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