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Expansion of monocyte subset could serve as a biomarker for HIV progressions
Date:3/27/2008

ening with HIV-infected patients where we might be able to see that immune impairment is taking place before we see a dramatic loss of CD4+ T cells, she said.

It looks like, based on these correlations, that this particular cell type may be involved in immune impairment and the progression of HIV, said Jay Rappaport, professor of neuroscience and neurovirology, who oversaw the study. Is it a good prognostic indicator" If you have a lot of these monocytes, does it mean you are going to progress into AIDS faster" Right now, all we know is what the correlations are, he said.

Rappaport added that he believes the CD163+/CD16+ monocyte subset is the first biomarker that correlates with viral load and CD4+ count. The fact that it actually correlates with both, we think, might make it a key cell type in the pathogenesis of AIDS. Fischer-Smith said the researchers plan to expand this study by following a cohort of patients longitudinally to see if their findings really can provide doctors with an early warning system and help to design better therapeutic strategies.

When you are just looking at a single time-point, you dont know how changes in this monocyte subset might occur over time, and how these changes might relate to the viral load and T cell number in individual patients, she said. That is why we want to investigate this further with a longitudinal study of HIV patients.


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Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-4380
Temple University
Source:Eurekalert

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