Navigation Links
Expansion of monocyte subset could serve as a biomarker for HIV progressions
Date:3/27/2008

An increase in the CD163+/CD16+ monocyte subset could be a biomarker for the progression of HIV disease, according to researchers at Temple University.

The researchers reported their findings, CD163/CD16 Coexpression by Circulating Monocytes/Macrophages in HIV: Potential Biomarkers for HIV Infection and AIDS Progression, in the March issue of AIDS Research and Human Retroviruses (www.liebertonline.com/aid).

A monocyte is a specific white blood cell, a part of the human bodys immune system that protects against blood-borne pathogens and moves quickly to sites of infection within the bodys tissues. As monocytes enter tissue, they undergo a series of changes to become macrophages.

The researchers were investigating alterations in this monocyte subset in patients with HIV infection. As part of this study, they examined a cohort of 18 patients from the Comprehensive HIV Program at Temple University Hospital, under the direction of Ellen Tedaldi, and seven individuals without HIV infection.

At first, we were just looking at whether or not we saw alterations in this CD163+/CD16+ subset and whether it might be reflective of the amount of virus they have in circulation, said Tracy Fischer-Smith, an associate scientist in Temples Neuroscience Department and the studys lead author. We did, indeed, find that patients with detectable virus had an increase of this monocyte subset that correlated with the amount of virus they had in their blood. We were surprised to find that patients with CD4+ T cell counts of less than 450 cells per microliter [200 or less per microliter is defined as AIDS], the increase of this monocyte subset correlates inversely with the number of T cells.

Fischer-Smith said this finding suggests that as the monocyte cells are increasing, these patients are losing CD4+ T cells, which are critical for the maintenance of immunological competence.

This may actually provide an earlier window into what is happening with HIV-infected patients where we might be able to see that immune impairment is taking place before we see a dramatic loss of CD4+ T cells, she said.

It looks like, based on these correlations, that this particular cell type may be involved in immune impairment and the progression of HIV, said Jay Rappaport, professor of neuroscience and neurovirology, who oversaw the study. Is it a good prognostic indicator" If you have a lot of these monocytes, does it mean you are going to progress into AIDS faster" Right now, all we know is what the correlations are, he said.

Rappaport added that he believes the CD163+/CD16+ monocyte subset is the first biomarker that correlates with viral load and CD4+ count. The fact that it actually correlates with both, we think, might make it a key cell type in the pathogenesis of AIDS. Fischer-Smith said the researchers plan to expand this study by following a cohort of patients longitudinally to see if their findings really can provide doctors with an early warning system and help to design better therapeutic strategies.

When you are just looking at a single time-point, you dont know how changes in this monocyte subset might occur over time, and how these changes might relate to the viral load and T cell number in individual patients, she said. That is why we want to investigate this further with a longitudinal study of HIV patients.


'/>"/>

Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-4380
Temple University
Source:Eurekalert

Related medicine news :

1. Lilly Grants $4.4 Million to the WHO for MDR-TB Program Expansion
2. Phillies Pitcher Jamie Moyer and Wife Karen Continue National Expansion - Bringing Bereavement Camps for Kids to Every Major League Baseball City
3. Heart Hospital of Austins Expansion Increases Patient Capacity by 30 Percent
4. Expansion Will Double Size of The Heart Center at Regions Hospital
5. Sikorsky Aircraft and PHI Celebrate Fleet Expansion and 20K Milestone at Heli-Expo
6. ADAMS Performs Management Services for University Hospitals $600 Million Expansion/Renovation Program in Cleveland, OH
7. MedCath Plans 60-bed Expansion at TexSAn Heart Hospital
8. Congress Poised to Reauthorize Legislation Aimed at Dramatic Expansion of Global HIV and AIDS Programs
9. Ingenious Med Reports Record Sales and Client Expansions in 2007
10. Jacobs Receives Contract from Catholic Healthcare West to Assist Sequoia Hospital Expansion Program
11. Kendle Appoints Industry Veteran to Lead Asia/Pacific Expansion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... December 09, 2016 , ... ... offices in Pasco and Richland, is initiating a charity drive to support the ... from a recent automobile collision. , On October 29th of this year, ...
(Date:12/9/2016)... ... 2016 , ... The Justin Veatch Fund announced Thursday that ... film Whispering Spirits and its discussion guide for use by all of ... in the war against teen drug abuse. NCADD is the oldest anti-addiction advocacy ...
(Date:12/9/2016)... ... December 09, 2016 , ... The ... Hotel in New York, NY, on December 3rd, to benefit Holy Name Medical ... the annual event, which raised over $1 million - the largest event in ...
(Date:12/8/2016)... ... 2016 , ... The West Virginia Medical Institute (WVMI) announced ... name change aligns the entire company with its existing Quality Insights branded projects ... are very proud of the achievements associated with the West Virginia Medical Institute ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... to announce that “Natural Language Processing–Enabled and Conventional Data Capture Methods for Input ... JMIR Medical Informatics . , Results of the comparative usability study demonstrate that ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... -- Australia Ophthalmic Lasers Market Outlook to 2022 ... Outlook to 2022", provides key market data on the ... millions of US dollars, volume (in units) and average ... Lasers and YAG Lasers. The report also provides ... these market segements, and global corporate-level profiles of the ...
(Date:12/8/2016)...  The global biosurgery market is expected to grow ... of 2016 to 2021. The market is poised to ... billion in 2016. The market is primarily driven by ... injuries and spinal problems, increasing clearance of biosurgery products ... loss management. In this report, the biosurgery ...
(Date:12/8/2016)... KEY FINDINGS North America ... market in 2016 and is expected to continue in ... a large number of surgical procedures that are taking ... in the patient temperature management market.) Patient warming and ... of blood during surgeries, lowering the risks of neurological ...
Breaking Medicine Technology: