Navigation Links
Exosomal release of beta-catenin may explain why CD82 and CD9 suppress tumor metastasis
Date:9/13/2010

Researchers reveal a new way in which cells restrain beta-catenin and potentially suppress tumor metastasis: the protein can be ejected from cells in small vesicles called exosomes. The study appears online on September 13 in the Journal of Cell Biology (www.jcb.org).

Beta-catenin is a central component of the Wnt signaling pathway that controls cell proliferation and differentiation. Activation of the Wnt pathway stabilizes beta-catenin, allowing it to move into the cell nucleus and control the expression of many different genes.

Michael Caplan's group at Yale University uncovered a new way in which cells restrain beta-catenin's activity. Overexpressing CD82 or CD9, members of the tetraspanin family of transmembrane proteins, suppressed Wnt signaling and reduced beta-catenin protein levels. Surprisingly, this decrease did not involve an established pathway of beta-catenin destruction. "We were sort of stumped," Caplan admits, "until we saw a talk that mentioned that tetraspanins like CD82 are associated with exosomes."

Exosomes are small vesicles that form inside endosomes by the inward budding of endosomal membranes. The vesicles are then secreted when the endosome fuses with the plasma membrane. The team found that CD9 and CD82 boosted the release of exosomes containing beta-catenin, thereby reducing cellular levels of the protein and inhibiting the Wnt pathway. Cells lacking CD9, on the other hand, produced fewer exosomes and showed higher Wnt signaling activity.

The exosomal release of beta-catenin may be compromised in certain cancers, where Wnt signaling is often hyperactive. CD82 and CD9 are both suppressors of metastasis whose expression is lost in several types of late stage tumor. Caplan and colleagues blocked Wnt signaling in a metastatic cell line after restoring CD82 expression. "CD82 may act as a metastasis suppressor by targeting beta-catenin for exosomal release and
'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Research!America releases vaccines fact sheet
2. HIV care providers and researchers applaud release of national HIV/AIDS strategy
3. New Release of Wombat Security Technologies' Cyber Security Training Game: Anti-Phishing Phil
4. MedPage Today Releases Free App for Android Phones
5. Bellaboo Releases One Girl At A Time Documentary
6. Relax, Release and Rejuvenate at Upcoming Women's Retreat
7. Purity Products Releases Alpha 3C
8. AAO-HNS releases consensus statement: diagnosis and management of nasal valve compromise
9. Resource guide for internists released by ACP
10. Apps For All Releases New iPhone/iPad Trend Setting App – Mood Lifters
11. DrFinders Releases Searchable Online Directory of Doctors for All Medical Needs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Exosomal release of beta-catenin may explain why CD82 and CD9 suppress tumor metastasis
(Date:3/1/2015)... Atlanta, GA (PRWEB) March 01, 2015 ... of Evelyn King and Carolyn Roddy to the professional ... Director of Compliance, graduated from The Ohio State University-Mortiz ... over 15 years of experience working with several Fortune ... specifically in the area of corporate benefits. Her experiences ...
(Date:2/28/2015)... February 28, 2015 In recent years Medical ... of practicing physicians as a way for them to expand ... regarding Cannabis as medicine. Since the FDA still lists Cannabis ... resources available to licensed physicians that can help guide ... Dr. Deborah Malka in Santa Cruz, CA is a ...
(Date:2/28/2015)... The Heart Fit Clinic started doing ... the machine. The Heart Fit Clinic is also selling ... franchise model. The goal is to scale the business ... To buy External Counterpulsation machines can be ... through this process and achieve the desired results. ...
(Date:2/28/2015)... 2015 Indosoft Inc , developers ... Asterisk, are pleased to announce the development of Q-Suite ... 5.8 versions of Q-Suite, this new version will include ... of new features to the leading edge call center ... 5.9 will add features to enhance security and protection. ...
(Date:2/28/2015)... February 28, 2015 National ... outsourced sales, marketing and supply chain management for ... Botanicals, is bringing its award winning solutions for ... Botanicals’ products are specifically created to combat thinning-damaged ... BIOTA is committed to marrying science with nature ...
Breaking Medicine News(10 mins):Health News:ERISAPros Recruits Evelyn King, J.D. and Carolyn Roddy, J.D. to its Professional Staff 2Health News:Reputable Cannabis Doctor In Santa Cruz and Monterey Joins the Medical Cannabis Network 2Health News:Clinicians Can Now Purchase External Counterpulsation with Heart Fit Clinic 2Health News:Indosoft Proudly Announces Q-Suite 5.9 Call Center Software for Asterisk 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 3
... said that suicide rates in Sri Lanka has increased in multifold ... oleander plants even for the most trivial reasons. ,This ... over the island. It has yellow trumpet-like flowers and a fruit ... and one of these seeds is enough to kill you, the ...
... Ashok Bhatt has confirmed the absence of bird-flu cases in ... yielded negative results. ,Kadar Murghiwala, a poultry dealer ... died. Suspecting a possible bird-flu infection following complaints of fever, ... an isolation ward. The symptoms of bird-flu as listed by ...
... diabetes. New South Wales (NSW) has recorded a 300% increase ... 10 years. Experts have asked the health system and the ... it continues it is expected that about 2 million will ... increase is that of the diet and lifestyle factors. About ...
... revamp the drug system. Health Minister George Smitherman said ... drug program//. He also said that he would introduce ... and sustainable. They will also speed up the slow ... The taxpayers have not received fair value for their ...
... infant and maternal mortality rates in the state, Madhya Pradesh ... a study conducted by a voluntary group//. ,The state, ... mortality rate of 83 per 1,000 childbirths while the maternal ... ,"Despite Madhya Pradesh having the second highest rate of ...
... chemical in the United States. It is obtained primarily ... yellow liquid at room temperature//. It has a sweet ... both natural processes and human activities. Benzene is also ... It is of exceptional importance commercially on account of ...
Cached Medicine News:Health News:Its High Time the Australian Government Takes Steps against Diabetes 2Health News:The Multi-Faceted Chemical Benzene 2Health News:The Multi-Faceted Chemical Benzene 3Health News:The Multi-Faceted Chemical Benzene 4Health News:The Multi-Faceted Chemical Benzene 5Health News:The Multi-Faceted Chemical Benzene 6
(Date:2/27/2015)... , Feb. 27, 2015  Two mass ... in applications as their effectiveness is established, ... Information.  Kalorama Information says that while mass ... most powerful tool in proteomic biomarker discovery ... through its traditional techniques has struggled to ...
(Date:2/26/2015)... 26, 2015  Today the National Safety Council ... and physical side effects of pain medications ... as Vicodin and Oxycontin, are safer options than over-the-counter ... prescription painkillers than on heroin and cocaine combined," said ... NSC. "Yet, these medications are marketed as the Cadillac ...
(Date:2/26/2015)... 2015 Every year many millions of donations ... disease.  Nevertheless, year after year doctors and the medical ... first test to determine the status of heart health ... not, even though that technology is over 100 years ... doctors know, (while most patients do not know) that ...
Breaking Medicine Technology:Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 3National Safety Council: Opioid prescription painkillers have hidden, deadly side effects 2National Heart Health Month In February 2
... Oct. 26, 2011 nContact, Inc., the leading innovator ... its new corporate websites, www.ncontactinc.eu and ... reflects the evolution of nContact,s technology and the market ... worldwide. "The new websites are excellent educational ...
... DIEGO, Oct. 26, 2011 ADVENTRX Pharmaceuticals, Inc. (NYSE ... met with the U.S. Food and Drug Administration (FDA) ... of ANX-514 (docetaxel for injectable emulsion), a detergent-free reformulation ... non-inferiority study (Study 514-02) with a primary objective of ...
Cached Medicine Technology:nContact, Inc. Launches New Corporate Websites 2ADVENTRX and FDA Reach Agreement on Pivotal Study for ANX-514 2ADVENTRX and FDA Reach Agreement on Pivotal Study for ANX-514 3ADVENTRX and FDA Reach Agreement on Pivotal Study for ANX-514 4
... Used for stone manipulation and removal in the ... basket to retain its shape following extreme torsion. ... capture by allowing the basket to open at ... stone. The tipless design reduces the likelihood of ...
... Used to establish and maintain nephrostomy ... segment promotes patency and allows the ... Supplied sterile in peel-open packages. Intended ... is advised; stent must not remain ...
... Used to provide drainage following open ... are employed to provide enhanced drainage ... provides maximum softness for enhanced patient ... to latex catheters. Supplied sterile in ...
... Used for percutaneous placement ... in the renal pelvis ... sterile in peel-open packages. ... CAUTION: Periodic evaluation is ...
Medicine Products: