Navigation Links
Exosomal release of beta-catenin may explain why CD82 and CD9 suppress tumor metastasis
Date:9/13/2010

Researchers reveal a new way in which cells restrain beta-catenin and potentially suppress tumor metastasis: the protein can be ejected from cells in small vesicles called exosomes. The study appears online on September 13 in the Journal of Cell Biology (www.jcb.org).

Beta-catenin is a central component of the Wnt signaling pathway that controls cell proliferation and differentiation. Activation of the Wnt pathway stabilizes beta-catenin, allowing it to move into the cell nucleus and control the expression of many different genes.

Michael Caplan's group at Yale University uncovered a new way in which cells restrain beta-catenin's activity. Overexpressing CD82 or CD9, members of the tetraspanin family of transmembrane proteins, suppressed Wnt signaling and reduced beta-catenin protein levels. Surprisingly, this decrease did not involve an established pathway of beta-catenin destruction. "We were sort of stumped," Caplan admits, "until we saw a talk that mentioned that tetraspanins like CD82 are associated with exosomes."

Exosomes are small vesicles that form inside endosomes by the inward budding of endosomal membranes. The vesicles are then secreted when the endosome fuses with the plasma membrane. The team found that CD9 and CD82 boosted the release of exosomes containing beta-catenin, thereby reducing cellular levels of the protein and inhibiting the Wnt pathway. Cells lacking CD9, on the other hand, produced fewer exosomes and showed higher Wnt signaling activity.

The exosomal release of beta-catenin may be compromised in certain cancers, where Wnt signaling is often hyperactive. CD82 and CD9 are both suppressors of metastasis whose expression is lost in several types of late stage tumor. Caplan and colleagues blocked Wnt signaling in a metastatic cell line after restoring CD82 expression. "CD82 may act as a metastasis suppressor by targeting beta-catenin for exosomal release and
'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Research!America releases vaccines fact sheet
2. HIV care providers and researchers applaud release of national HIV/AIDS strategy
3. New Release of Wombat Security Technologies' Cyber Security Training Game: Anti-Phishing Phil
4. MedPage Today Releases Free App for Android Phones
5. Bellaboo Releases One Girl At A Time Documentary
6. Relax, Release and Rejuvenate at Upcoming Women's Retreat
7. Purity Products Releases Alpha 3C
8. AAO-HNS releases consensus statement: diagnosis and management of nasal valve compromise
9. Resource guide for internists released by ACP
10. Apps For All Releases New iPhone/iPad Trend Setting App – Mood Lifters
11. DrFinders Releases Searchable Online Directory of Doctors for All Medical Needs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Exosomal release of beta-catenin may explain why CD82 and CD9 suppress tumor metastasis
(Date:7/31/2015)... ... August 01, 2015 , ... The Honor Society of Nursing, Sigma Theta ... Future of Nursing (GAPFON) 20-21 July 2015 in San Juan, Puerto Rico. Key nurse ... , Dr. Silvia Cassiani, Advisor, Nursing and Allied Health Personnel Development, Unit of Human ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... new industry players to know in predictive health analytics , Jvion continues ... technologies. The firm creates predictive software that targets patient and population level illness ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... There’s no ... possible, even when it comes time to cook the next meal, making July the ... July by practicing best grilling tips and recipes. , Make the next cookout different ...
(Date:7/31/2015)... PA (PRWEB) , ... July 31, 2015 , ... M3 ... is excited to launch three new Board Exam Courses. , The additions of ... Doc Board Exam Prep from MDLinx makes preparing for the exam easy and painless. ...
(Date:7/31/2015)... ... July 31, 2015 , ... Well-known for its unique pastries ... wedding cakes with custom designs, making life just a little bit sweeter for ... cakes for each customer who orders one. , The bakery provides a full line ...
Breaking Medicine News(10 mins):Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 3Health News:Pastry Palace of Las Vegas Announces It Is Now Offering Custom Wedding Cakes in Las Vegas 2
... of One Couple,s Struggle with Alzheimer,s , , WASHINGTONVILLE, N.Y., ... comfort the over 5 million Americans currently living with Alzheimer,s disease ... is proud to announce the release of her book, "Released to ... by iUniverse ). , , "Released to the Angels" ...
... , AUSTIN, Texas, June 2 Rules-Based Medicine, Incorporated ... Tony Barnes, Ph.D., MBA, has joined the Company as ... marketing and operational leadership as RBM commercializes new biomarker-based ... established provider of multiplex biomarker assays for improved drug ...
... effort to enroll women in revolutionary initiative to eradicate breast cancer ... The Avon Foundation and the Dr. Susan Love Research Foundation are ... Women, ( www.armyofwomen.org ) will be supported by AARP, ... are proud and excited to have received the AARP,s support," says ...
... Health Solutions, Inc. (Nasdaq: STRM ) announced today that ... the period ended April 30, 2009 on Tuesday, June 9, 2009 ... and web cast to review the results on Tuesday, June 9 ... the call by dialing (800) 860-2442 or (412) 858-4600, or can ...
... , ... death of abortionist, George Tiller, the American people and those around the world will have ... one unaffiliated criminal speak for an entire movement, or do the actions of hundreds of ... ...
... ... new CE/CEU course entitled A Review of Pain Screening Instruments for ... the Pain Patient to their extensive online library of nationally-approved continuing ... workers. While there is an increase in the number of ...
Cached Medicine News:Health News:The Unexpected Gifts of Alzheimer's 2Health News:The Unexpected Gifts of Alzheimer's 3Health News:Rules-Based Medicine, Inc. Names Tony Barnes to Lead Expanding Diagnostics Business 2Health News:AARP to Support the Love/Avon Army of Women 2Health News:Streamline Health to Announce First Quarter Fiscal Year 2009 Financial Results on Tuesday, June 9, 2009 2Health News:Streamline Health to Announce First Quarter Fiscal Year 2009 Financial Results on Tuesday, June 9, 2009 3Health News:The Killing of George Tiller: Video "Thine Eyes" Shows True Face of Pro-life Movement in the Face of 'Terrorist' Accusations 2Health News:HealthForumOnline Offers New Online CE/CEU Course on Pain Screening Instruments for Medical and Mental Health Providers 2Health News:HealthForumOnline Offers New Online CE/CEU Course on Pain Screening Instruments for Medical and Mental Health Providers 3Health News:HealthForumOnline Offers New Online CE/CEU Course on Pain Screening Instruments for Medical and Mental Health Providers 4
(Date:7/30/2015)... Calif. , July 30, 2015 IRIDEX ... will release its second quarter 2015 financial results after ...   In conjunction with the release, the Company will ... 5:00 p.m. Eastern Time on Thursday, ... the quarter and other business developments. Interested ...
(Date:7/30/2015)... 30, 2015  Unichem Pharmaceuticals ( USA ... Hydrochlorothiazide tablets 25 mg 1000-count bottle to the consumer ... measure due to the identification of a Clopidogrel tablet ... The risk associated with mistakenly taking a Clopidogrel ... probability of experiencing Clopidogrel,s side effects which include bleeding ...
(Date:7/30/2015)... -- Tianyin Pharmaceutical Inc. (NYSE Amex: TPI ) ... patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded generics ... notice it received on May 21, 2015 from the ... was below certain of the Exchange,s continued listing standards, ... the NYSE MKT Company Guide, due to the delay ...
Breaking Medicine Technology:IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2TPI Provides Update Regarding Non-Compliance with NYSE MKT Continued Listing Requirements 2
... MISSISSAUGA, Ontario, June 22, 2011 CardioGenics Holdings ... magnetic beads business unit, which develops ultra sensitive ... its Canadian subsidiary, Luxspheres Inc. The beads business ... Company,s CardioGenics Inc. Canadian subsidiary ("CardioGenics"), will now ...
... N.J., June 22, 2011 ... Co. Ltd., and an international specialty pharmaceutical company, today ... Food and Drug Administration (FDA) for Rectiv™ (nitroglycerin) Ointment ... pain associated with chronic anal fissures.  Rectiv will be ...
Cached Medicine Technology:CardioGenics Transfers Magnetic Beads Business Unit Into its Luxspheres Inc. Subsidiary 2CardioGenics Transfers Magnetic Beads Business Unit Into its Luxspheres Inc. Subsidiary 3ProStrakan Receives FDA Approval for Rectiv™ for the Treatment of Moderate to Severe Pain Associated With Chronic Anal Fissures 2ProStrakan Receives FDA Approval for Rectiv™ for the Treatment of Moderate to Severe Pain Associated With Chronic Anal Fissures 3
... stabilizer is an example of advanced technology ... the compression and comfort of a soft ... an ankle stirrup. A plastic exoskeleton ... fabric, forming a network of strategically placed ...
... with three regulated communicative chambers. It's one ... of low profile pneumatics to dramatically increase ... in other stirrups. The "slow rebound" air ... is enclosed and protected to prevent puncture. ...
... X-Brace is a cost effective stirrup designed to ... rehabilitation. It is lower in profile than other ... increasing potential patient compliance. The X-Brace offers the ... instep, and everts the foot. This allows the ...
... has a rigid shell with a vacuum liner ... The VacoSplint is a non-weight bearing splint. Once ... should transfer to the STORM walker boot., ... liner from the STORM and insert the vacuum ...
Medicine Products: