Navigation Links
ExonHit Presents Therapeutic and Diagnostic Programs for Alzheimer's at ICAD 2008

PARIS and GAITHERSBURG, Maryland, July 2 /PRNewswire-FirstCall/ -- ExonHit Therapeutics (ALTERNEXT-NYSE EURONEXT : ALEHT ; ISIN : FR0004054427), a drug and diagnostic company, today announced its presence at the International Conference on Alzheimer's Disease (ICAD 2008) taking place in Chicago (Illinois), July 26 to 31.

On this occasion, ExonHit will reveal several posters and participate in an oral presentation, entitled "EHT 0202: A Neuroprotective And Procognitive Alpha-secretase Stimulator Targeted Towards Alzheimer Disease Therapy", lead by Matthew Pando, Ph.D., Executive Vice President - Therapeutics of ExonHit.

"We're particularly delighted to take part in this international conference and we're proud to present all of our therapeutic developments and diagnostic innovations to the major experts and researchers in the neurodegenerative diseases. Based on its unique technological platform of alternative splicing, ExonHit has been working for years on building an efficient Alzheimer's franchise. It focuses on the development of a new generation of blood diagnostic tests but also on the discovery of innovative therapeutic solutions in a area where ExonHit has to line up among the top leading companies", has declared Philippe Rousseau, Chairman of the Management Board and Chief Financial Officer of ExonHit.

On the basis of several unique proprietary technologies of analysis of transcripts with alternative splicing, ExonHit built indeed a solid portfolio of both therapeutic and diagnostic products.

Nowadays, ExonHit is mostly developing two fully proprietary programs in Alzheimer's disease. The first one, relative to the EHT 0202 compound, is in fact on phase II of clinical trials. Based on a new action mechanism EHT 0202 redirects the processing of APP (Amyloid Precursor Protein), which plays a pivotal role in the evolution of Alzheimer's disease, at the expense of the beta amyloid peptide (Aβ). EHT 0202 could represent a major therapeutic breakthrough. The second program, EHT 206, is in pre-clinical stage and focuses on the development of new chemical entities aiming at inhibiting the formation of senile plaques, largely composed of aggregated beta amyloid peptides (Ass). These plaques, responsible for the neurons' death, play a main role in the loss of cognitive functions with patients suffering from the Alzheimer's disease.

In the field of blood-based Alzheimer's disease test, ExonHit presently leads several studies as part of the EHTDx21 project. Theses studies intend to confirm, on a new set of patients, the ability of the test to isolate Alzheimer patients from healthy individuals who show no signs of dementia. They also aim at measuring the ability of this test to differentiate the Alzheimer's dementia from other forms of dementias. ExonHit expects to provide in 2009 the pharmaceutical industry with its first version of the EHTDx21 test and so become one of the first worldwide firms to offer a blood diagnostic test devoted to this pathology.

ICAD data highlights include :


Poster session: "EHT 0202, An Alpha-secretase Stimulator Active Against Amyloid-Beta Accumulation And Neurotoxicity That Improves Attention And Cognition"

Date/Time : Monday Jul 28, 2008 12:30 PM - 3:00 PM

Poster session: "Development Of A Screening Platform For The

Identification Of New Rac1/Rac1b Inhibitors Active In

The Prevention Of Amyloid-beta Production"

Date/Time : Monday Jul 28, 2008 12:30 PM - 3:00 PM

Oral presentation: "EHT0202: A Neuroprotective And

Procognitive Alpha-secretase Stimulator Targeted

Towards Alzheimer Disease Therapy"

Date/Time : Tuesday Jul 29, 2008 3:00 PM - 5:00 PM in the

Therapeutic Strategies Session


Poster for Dx21: "Discovery Of Blood Gene Expression

Biomarkers In Alzheimer's Disease Using The Human

Genome-wide Splicearray",

Date/Time : Sunday Jul 27, 2008 12:30 PM - 3:00 PM

About ICAD :

The premier Alzheimer conference. As a part of the Alzheimer's Association research program, this international conference serves as a catalyst for generating new knowledge about dementia and fostering a vital, collegial research community. This meeting will bring together more than 5,000 researchers, physicians and care providers from 60 countries - the largest group of international leaders in Alzheimer research and care ever convened. ICAD boasts more than 2,000 sessions. Plenary, symposia, oral and poster session topics include: Genetics, epidemiology and risk factors, Cellular and animal models, Neuropathology of amyloid, lipid biochemistry, Early detection and diagnosis, neuroimaging and biomarkers, Current interventions and future therapies... (

About ExonHit Therapeutics :

ExonHit Therapeutics is the world's leader in the analysis of alternative RNA splicing, a process which when deregulated plays a key role in the onset of various diseases.

ExonHit has a multi-component commercial strategy to capture the maximum value from its leadership in alternative splicing. The Company is already generating revenues from a new generation of microarrays, SpliceArrayTM family of products that enable life science researchers to detect crucial disease-associated information. These products are marketed worldwide in conjunction with Agilent and Affymetrix.

In the field of diagnostics, ExonHit has a major collaboration with bioMerieux to develop completely novel predictive blood-based cancer diagnostics, which could play a key role in improving the treatment of breast cancer and other major cancers and develops its own projects for the detection of other chronic diseases such as Alzheimer's disease or atherosclerosis.

In parallel, ExonHit is developing its own therapeutic pipeline in the field of neurodegenerative diseases and cancer. The Company has advanced drug candidates into clinical trials and is evaluating several promising pre-clinical compounds. ExonHit also has a strategic partnership with Allergan, to discover and develop new therapeutics in the areas of pain, neurological diseases and ophthalmology. This collaboration provides on-going research funding to ExonHit.

Founded in 1997, ExonHit is headquartered in Paris, France and has a U.S. facility in Gaithersburg, Maryland. The Company is listed on Alternext of Euronext Paris (ticker: ALEHT; ISIN: FR0004054427) since November 17, 2005.

This press release may be drafted in the French and English languages. In an event of differences between the texts, the French language version shall prevail.

SOURCE ExonHit Therapeutics SA
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Updated GOLD report presents new understandings in diagnosis, treatment and prevention of COPD
2. The Art Of Maternity(TM) at Destination Maternity(R) Presents A Sacred Passage Into Motherhood; the Art of Belly Masking to Belly Casting
3. Presentation Time Correction: Keryx Biopharmaceuticals Presents at 12:00pm, ET Tomorrow (Oct. 3) at William Blair & Company Small-Cap Growth Stock Conference
4. VNUS Medical Technologies Presents at William Blair Small-Cap Growth Stock Conference
5. NARSAD - Worlds Leading Mental Health Research Charity - Presents 19th Annual New York Mental Health Symposium, Oct. 19th & 20th
6. Retirement Living TV Presents Sex, Drugs and Rock N Roll
7. AviaraDx Presents at 2007 BIOCOM Investor Conference
8. NARSAD - the Worlds Leading Mental Health Research Charity - Presents 2007 Prizes for Outstanding Psychiatric Research at New York Gala, October 19th
9. California Science Center Science Matters Speakers Program Presents The Science and Ethics of Fear
10. Borgata Heart & Soul Foundation Presents Third Annual Women in Wine Event
11. SafeSmart, Inc. Presents SafetyTies to Sixth Annual MedAssets Technology Forum
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... As part ... For Empowerment ™ attracts volunteers together who want to combine talents and resources ... key stakeholders in the process. The non-profit launched its first major fundraiser on ...
(Date:11/25/2015)... ... 25, 2015 , ... Finnleo, a leader in the traditional and far-infrared sauna ... and far-infrared saunas. , For traditional saunas, Finnleo is offering 20% ... wood, and Finnleo uses only European Grade A Nordic White Spruce from sustainably grown ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... sauna parts and accessories. , Sauna accessories help improve the bather experience in ... personality. From basic styles for the purist looking for simplicity in design to ...
(Date:11/25/2015)... ... 26, 2015 , ... Ministers, senior government and UN agencies, ... Centres of Excellence, and public R&D institutions, civil societies and other partners gathered ... 5th African Network for Drugs and Diagnostics Innovation, ANDI, Stakeholders Meeting. The three- ...
(Date:11/25/2015)... ... 2015 , ... For the first time, Vitalalert is donating half of its ... The partnership between the two groups began in 2014 with Vitalalert pledging a portion ... International was founded in 1954 and is an international Christian-based health organization whose mission ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Drug Monitoring (TDM) Market: Supplier Shares, ... Opportunities"  report to their offering.  ... the addition of the  "2016 Future ...
(Date:11/26/2015)... 26, 2015 Research and Markets ( ... "2016 Future Horizons and Growth Strategies in ... Shares, Country Segment Forecasts, Competitive Intelligence, Emerging Opportunities" ... --> --> This new ... Italian therapeutic drug monitoring market, including emerging tests, ...
(Date:11/25/2015)... , Nov. 25, 2015 ... addition of the "Global Brain Monitoring ... offering. --> ) has ... Brain Monitoring Devices Market 2015-2019" report ... and Markets ( ) has announced ...
Breaking Medicine Technology: