Navigation Links
Existing medicines show promise for treating stomach and bowel cancer
Date:2/4/2014

Stomach and bowel cancer, two of the most common cancers worldwide, could be treated with a class of medicines that are currently used to treat a blood disorder, a Melbourne research team has discovered.

The finding, in preclinical models, that medicines called 'JAK inhibitors' reduce the growth of inflammation-associated stomach and bowel cancer provides the first evidence supporting their use in treating these cancers.

JAK inhibitors are currently used to treat the cancer-like condition myelofibrosis, and are being investigated in clinical trials for the treatment of conditions including leukaemia, lymphoma, lupus and rheumatoid arthritis.

Dr Emma Stuart, Dr Tracy Putoczki and Associate Professor Matthias Ernst from the Walter and Eliza Hall Institute made the discovery with colleagues while at the Melbourne-Parkville Branch of the Ludwig Institute for Cancer Research. Associate Professor Ernst is also currently a Ludwig Member. Their findings have been published in the journal Molecular Cancer Therapeutics.

Stuart said the discovery stemmed from the research team's long interest in the links between inflammation and cancers of the digestive tract. "Recently we have begun to unravel the complex signaling that occurs in inflamed tissues, such as when a person has a stomach ulcer or suffers from inflammatory bowel disease, and how this drives cancer development," she said.

"By understanding the molecules that are involved in promoting the survival and growth of cancer cells, we have been able to identify which of these molecules can be targeted with potential anti-cancer treatments. In this case, we determined that proteins called JAKs are involved in cancer formation in the stomach and bowel. It was exciting to discover that when JAKs were blocked with existing medications (JAK inhibitors), bowel and stomach cancer growth in experimental models was slowed, and many of the cancer cells were killed," Stuart said.

Ernst said the findings were significant as JAK inhibitors were already available and had shown success in clinical trials, particularly for treating cancer-like blood conditions.

"Our team's research has uncovered several proteins that could be valuable targets in treating cancers of the digestive tract," he said. "The reason this discovery is particularly exciting is clinical trials have already shown that JAK proteins can be safely and successfully inhibited in patients. We hope this will expedite bringing our research to possible clinical trials that may improve the outlook for people with stomach and bowel cancer," Ernst said.


'/>"/>

Contact: Vanessa Solomon
solomon@wehi.edu.au
61-393-452-971
Walter and Eliza Hall Institute

Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research


Source:Eurekalert  

Related medicine news :

1. India Network International Visitor Health Insurance Announces Higher Pre-existing Coverage Limits for Visitors of All Ages
2. OnPage Pager Replacement and Priority Messaging Software can Now be Activated via Your Existing Communication Terminals
3. No Medical Exam Life Insurance Is A Simple Method Of Getting Coverage For People Who Have A Pre-Existing Medical Condition
4. Life Insurance Without Exam Is Available For People Who Have A Pre-Existing Medical Condition
5. India Network Visitor Health Insurance Plan Offers New Options for Preexisting Conditions Coverage for All Ages, 0 to 99 Years Old
6. Plaintiffs in 77 Risperdal Gynecomastia Lawsuits File Motion to Force J&J to Comply with Existing Settlement Agreement, Reviewed By Wright & Schulte LLC
7. Curb Premature Wrinkling or Reduce Existing Wrinkles With Sublime Beauty Products, Including a New Hyaluronic Serum on Sale This Week
8. India Network Foundation Seeks Community Input on Pre-Existing Conditions Visitor Health Insurance Programs for 2014
9. Obamacare Changes Network to Medicare from United Health Care for All Policy Holders of Pre-existing Health Insurance Plan
10. simplifyMD’s EHR Software Selected to Replace Existing Technology at Celebration Orthopaedic & Sports Medicine Institute
11. IMG Add Moratorium Option, Increasing Likelihood of Pre-existing Conditions Cover for Globalsurance Clients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Existing medicines show promise for treating stomach and bowel cancer
(Date:12/8/2016)... ... December 08, 2016 , ... Healthcare is in flux. The ... for the mass media launching of story movements to highlight what's most unfair ... unfortunate experiences; such a movement can generate the network power to improve healthcare ...
(Date:12/8/2016)... OH (PRWEB) , ... December 08, 2016 , ... ... insurance and financial planning services from offices headquartered in Hamilton County, is embarking ... rescue LuvFurMutts. , LuvFurMutts specializes in finding new homes for orphaned or neglected ...
(Date:12/8/2016)... ... 08, 2016 , ... Coppin Insurance Agency, an insurance and financial planning firm ... Cape Coral area, is embarking on a charity drive with the goal of providing ... Harry Chapin Food Bank of Southwest Florida works to provide fresh and nutritious food ...
(Date:12/8/2016)... KS (PRWEB) , ... December 08, 2016 , ... ... financial consultation services to families and business owners in and around central Kansas, ... provide assistance to at-risk youth in the region. , Headquartered in Wichita, Youth ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... of the most comprehensive mental health systems reform legislation in more than fifty ... President, and the commitment of our elected officials to improving mental health services ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... DUBLIN , Dec 8, 2016 Research ... 2016-2020" report to their offering. ... , The global chromatography market ... Global Chromatography Market 2016-2020, has been prepared based on an ... market landscape and its growth prospects over the coming years. The report ...
(Date:12/8/2016)... India , December 8, 2016 ... report "Sugar-Based Excipients Market by Product (Actual Sugars, ... Functionality (Filler & Diluent, Tonicity Agents), Formulation (Oral, ... by MarketsandMarkets, the market has witnessed healthy growth ... grow at a CAGR of 4.3% between 2016 ...
(Date:12/8/2016)... SAN FRANCISCO, Calif. , Dec. 8, 2016 ... nuclease technology to develop novel antiviral therapeutics, today ... M.D., as chief executive officer and a member ... is an incredibly experienced executive with a deep ... said Stephen Quake, D.Phil., founder of Agenovir, co-president ...
Breaking Medicine Technology: