Navigation Links
Existing Drug May Lead to ALS Treatment
Date:10/20/2009

Researchers hope to start testing in patients within five years

TUESDAY, Oct. 20 (HealthDay News) -- A drug similar to one now used to treat blood poisoning holds promise as a treatment for amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, researchers say.

At the moment, the drug has only been tested in mice, and there's no guarantee that it would have similar effects in humans, the scientists noted.

In the study, the researchers were able to extend the life span of mice with a severe form of the disease by 25 percent. The mice were also better able to live normal lives and didn't suffer from muscle degeneration as quickly.

ALS, which harms the motor-related neurons in the brain, brainstem and spinal cord, causes paralysis and usually leads to death within five years. There is currently no cure or treatment that can slow progression of the disease.

The new research found that a compound already used in other patients appears to protect neurons that are under attack in ALS. The compound, a form of an enzyme known as activated protein C, is already used to treat blood poisoning, but it can cause an increased risk of bleeding, and researchers don't think it will work as a treatment for ALS. As a result, they are looking for ways to tinker with the compound to boost its chances of serving as an appropriate treatment.

Study co-author Dr. Berislav Zlokovic, a neuroscientist at the University of Rochester Medical Center, noted in a university news release that there is one benefit to the compound: It's approved for use through injection, while other treatments under development need surgery to be administered.

The researchers hope to test the treatment in humans within the next five years.

The research was published online Oct. 19 in the Journal of Clinical Investigation.

More information

Learn more about amyotrophic lateral sclerosis from the ALS Association.



-- Randy Dotinga



SOURCE: University of Rochester Medical Center, news release, Oct. 19, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. National Womens Law Center Challenges Insurance Industry Practices That Treat Being a Woman Like a Pre-Existing Condition
2. Pre-Existing Health Conditions - Cops, Firefighters, Expectant Dads, and Those Suffering From Allergies, Acne and Toenail Fungus Are Uninsurable According to Internal Documents
3. MissionWise Adds Projects from New and Existing Clients: Helps Nonprofits Become More Sustainable
4. First Customer Installs CyberKnife System in Existing Radiation Therapy Vault
5. New heart disease risk score outperforms existing test
6. Lumenis Completes $15 Million Equity Financing From New and Existing Investors
7. Cytox Raises Pre-Series A Financing From Management and Existing UK Investors, Welcomes First US Investors
8. SETO Holdings, Inc. Completes Agreement to Acquire Advanced Hearing Centers, Inc. and Has Disposed of All Existing Business; New Management has been installed
9. SETO Holdings, Inc. Signs Agreement to Acquire Advanced Hearing Centers, Inc. and Will Dispose of All Existing Business; New Management to be Installed
10. Patient Command Tells Sec. Sebelius That Existing Technology Can Make Electronic Health Records Interoperable
11. Whitepaper Shines Light on Administrative Waste: Offers Practical Steps for Cutting Healthcare Costs through Existing Infrastructure, Collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... IL (PRWEB) , ... October 13, 2017 , ... ... which established the certification process to promote standards of excellence for the field ... Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at the ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized health ... expanded their existing home health joint venture through an agreement, effective October 1, ... joint venture home health company with Asante, delivering clinically integrated care, for the ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:10/2/2017)... 2017 The Rebound mobile app is poised to ... the tide of prescription drug addiction. The app empowers users ... and stepping down their dosage in a safe, controlled manner ... 2017; the first 100,000 people to sign up will enjoy ... ...
(Date:9/27/2017)... Israel and NEW YORK , Sept. 27, ... with mobile health and big data solutions, today announced that its MyDario ... Please check your local TV listings for when The Dr. Oz Show ... ... season this month. ...
Breaking Medicine Technology: