Navigation Links
Existing Drug May Lead to ALS Treatment
Date:10/20/2009

Researchers hope to start testing in patients within five years

TUESDAY, Oct. 20 (HealthDay News) -- A drug similar to one now used to treat blood poisoning holds promise as a treatment for amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, researchers say.

At the moment, the drug has only been tested in mice, and there's no guarantee that it would have similar effects in humans, the scientists noted.

In the study, the researchers were able to extend the life span of mice with a severe form of the disease by 25 percent. The mice were also better able to live normal lives and didn't suffer from muscle degeneration as quickly.

ALS, which harms the motor-related neurons in the brain, brainstem and spinal cord, causes paralysis and usually leads to death within five years. There is currently no cure or treatment that can slow progression of the disease.

The new research found that a compound already used in other patients appears to protect neurons that are under attack in ALS. The compound, a form of an enzyme known as activated protein C, is already used to treat blood poisoning, but it can cause an increased risk of bleeding, and researchers don't think it will work as a treatment for ALS. As a result, they are looking for ways to tinker with the compound to boost its chances of serving as an appropriate treatment.

Study co-author Dr. Berislav Zlokovic, a neuroscientist at the University of Rochester Medical Center, noted in a university news release that there is one benefit to the compound: It's approved for use through injection, while other treatments under development need surgery to be administered.

The researchers hope to test the treatment in humans within the next five years.

The research was published online Oct. 19 in the Journal of Clinical Investigation.

More information

Learn more about amyotrophic lateral sclerosis from the ALS Association.



-- Randy Dotinga



SOURCE: University of Rochester Medical Center, news release, Oct. 19, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. National Womens Law Center Challenges Insurance Industry Practices That Treat Being a Woman Like a Pre-Existing Condition
2. Pre-Existing Health Conditions - Cops, Firefighters, Expectant Dads, and Those Suffering From Allergies, Acne and Toenail Fungus Are Uninsurable According to Internal Documents
3. MissionWise Adds Projects from New and Existing Clients: Helps Nonprofits Become More Sustainable
4. First Customer Installs CyberKnife System in Existing Radiation Therapy Vault
5. New heart disease risk score outperforms existing test
6. Lumenis Completes $15 Million Equity Financing From New and Existing Investors
7. Cytox Raises Pre-Series A Financing From Management and Existing UK Investors, Welcomes First US Investors
8. SETO Holdings, Inc. Completes Agreement to Acquire Advanced Hearing Centers, Inc. and Has Disposed of All Existing Business; New Management has been installed
9. SETO Holdings, Inc. Signs Agreement to Acquire Advanced Hearing Centers, Inc. and Will Dispose of All Existing Business; New Management to be Installed
10. Patient Command Tells Sec. Sebelius That Existing Technology Can Make Electronic Health Records Interoperable
11. Whitepaper Shines Light on Administrative Waste: Offers Practical Steps for Cutting Healthcare Costs through Existing Infrastructure, Collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... The ... among the top five firms in the “2015/2016 Best in KLAS: Software and ... Staffing. KLAS is a research and insights firm on a global mission to ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... advocates will discuss how to improve care by making data on heart procedures ... disease. The Summit on Transparency and Public Reporting of Pediatric and Congenital Heart ...
(Date:2/11/2016)... ... ... In a new paper published in the latest issue ... Rohrich, and colleagues, examine and underscore the importance of upper lateral cartilage in ... this vital area. , The upper lateral cartilage in rhinoplasty, refers to a ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... unparalleled clinical decision support technology, with highly adaptable algorithms, has been updated to ... patient has signs and symptoms consistent with Zikas and a travel history to ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... motivational speaker, trainer and author Ray Clarke poses a question as a challenge ... . In his book, "Being in the Being" (published by Partridge Singapore), Clarke ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... SAN FRANCISCO , Feb. 11, 2016 Potrero ... system, is pleased to announce the appointment of George ... San Antonio, TX , WellMed is ... servicing over 200,000 patients and HMO members in ... founding WellMed in 1990 out of his own internal medicine ...
(Date:2/11/2016)... Ore. , Feb. 11, 2016 Wellpartner, ... announce the acquisition of SolutionsRx, a full-service 340B company ... Along with providing traditional contract pharmacy services, SolutionsRx also ... clients in navigating the complex 340B regulatory environment. ... --> James R. Love , CEO of ...
(Date:2/11/2016)... , Ill. and INDIANAPOLIS , Feb. 11, ... many young people, but for those with type 1 ... do these students juggle class schedules, assignments and campus ... with type 1 diabetes. On top of that, many ... Diabetes Scholars Foundation (Foundation) Lilly Diabetes ...
Breaking Medicine Technology: