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Exiqon Announces Achievement of Primary Milestones in RNAi Project for Tacere Therapeutics
Date:9/18/2009

Exiqon A/S (NASDAQ OMX Copenhagen: "EXQ") today announced the successful completion of several key milestones in a custom-designed RNAi project for Tacere Therapeutics.

San Jose and Copenhagen (PRWEB) September 18, 2009 -- Exiqon A/S (NASDAQ OMX Copenhagen: "EXQ") today announced the successful completion of several key milestones in a custom-designed RNAi project for Tacere Therapeutics. This project resulted from a collaboration between Tacere and Pfizer Inc. to develop and commercialize the TT-033 family of compounds to provide a potential single-administration treatment for the Hepatitis C virus (HCV).

Exiqon was selected to complete a series of customized assays, aimed at the detection of therapeutic shRNA molecules currently under development by Pfizer and Tacere, using Exiqon's proprietary LNA™ technology platform. The assays will be used to assess critical performance points for the RNAi therapeutic in a pre-clinical setting.

"The ability to quantify the levels and assess the biodistribution of therapeutic RNAi are critical issues for those in the field who are developing the technology as a new therapeutic modality," says David Suhy, PhD, Director of Research & Development for Tacere. "Unfortunately, the use of traditional quantitative assays to obtain these data has been hampered by the exceptionally small size of the RNA. The combination of the unique properties of LNA-enhanced oligonucleotides and the demonstrated scientific expertise of the Exiqon team made them an attractive partner for this project."

The nature of the specimens posed a significant challenge for this kind of assay, according to members of the Exiqon development team. "Unlike many detection assays of this kind, which
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Exiqon Announces Achievement of Primary Milestones in RNAi Project for Tacere Therapeutics
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