Navigation Links
Exeter engineers create new technique for malaria diagnosis
Date:4/27/2008

Researchers from the Universities of Exeter and Coventry have developed the first new technique for diagnosing malaria able to challenge the rapid diagnostic tests (RDTs) currently used in the field. Early results, now published in the Biophysical Journal, suggest that the technique could be as effective as RDTs but far faster and cheaper, making it a potentially viable alternative. The team is now working on a non-invasive version of the device, which with the assistance of a team from the Royal Tropical Institute (KIT), Department of Biomedical Research in Amsterdam, it is planning to trial in Kenya later this year.

Two years in the making and funded by the European Union, this technique uses magneto-optic technology (MOT) to detect haemozoin, a waste product of the malarial parasite, in the blood. Haemozoin crystals are weakly magnetic and have a distinct rectangular form. They also exhibit optical dichroism, which means that they absorb light more strongly along their length than across their width. When aligned by a magnetic field they behave like a weak Polaroid sheet such as used in sunglasses. This new technology takes advantage of these properties to give a precise reading of the presence of haemozoin in a small blood sample. The team has created a device, which gives a positive or negative reading for malaria in less than a minute.

The new device has a totally different approach from RDTs, which use a chemical agent to detect antigens associated with the malarial parasite. One of the problems with RDTs is that they need to be kept within a given temperature range, which is difficult in hot climates. These disposable kits cost between $1.50 and $4.50 each and take around 15 minutes to deliver a reading.

High-power microscopy is still the best method available for malaria diagnosis and has been used for more than a century. Unfortunately it is time-consuming and requires expensive equipment and specialist medical skills, which are rarely available in villages in rural areas in malaria endemic countries. Over the last decade RDTs have been developed, which allow for faster diagnosis in the field, but these are too costly to be viable for developing countries. Furthermore, RDTs are often not stable at relatively high temperatures and sometimes remain positive even after successful treatment. In many communities where malaria is having a severe impact on health, there is no testing for malaria and young children who have a fever are given anti-malaria drugs as a matter of course. This has contributed to the malarial parasite becoming increasingly resistant to the common anti-malaria drugs. Malaria is a disease for which there is still no vaccine.

Professor Dave Newman of the University of Exeters School of Engineering, Computing and Mathematics, said: There is an urgent need for a new diagnostic technique for malaria, particularly in the light of global warming, which threatens to spread the disease into new parts of the world, including southern Europe. The early results from our device are very promising and hugely exciting. We expect to ultimately produce a sensitive non-invasive device that will be cost effective and easy to use, making it suitable for developing countries, where the need is greatest.


'/>"/>

Contact: Sarah Hoyle
s.hoyle@exeter.ac.uk
01-392-262-062
University of Exeter
Source:Eurekalert

Related medicine news :

1. Congressional R&D Caucus co-chairs join scientists, engineers and graduate students
2. World-renowned bioengineers to record history of medical inventions
3. Sheffield engineers have big ideas for the latest in medical scanners
4. Microbes as climate engineers
5. Engineers use bloods hydrodynamics to manipulate stem, cancer cells
6. SMRT Architects and Engineers Selected to Design New $115M Digital X-Ray Manufacturing Facility for GE Healthcare
7. Engineers developing new cements to heal spinal fractures
8. Versus Technology, Inc. Announces Collaboration with Cleveland Clinic to Create Clinical Patient Flow Model
9. Rik Deitsch, CEO of Nutra Pharma Creates Personal Wall on WallSt.nets Financial Social Community, my.wallst.net
10. Susan Byrne joins GHG Grey Healthcare Group as EVP, Strategy and Business Development, Europe, a Newly-Created Position
11. Hearts Stem Cells Not Created Equally
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... February 13, 2016 , ... In its newly released Infusion ... technology should be used to ensure patient safety when placing an IV catheter. ... mandate the use of vein visualization technology in patients with difficult venous access ...
(Date:2/12/2016)... , ... February 12, 2016 , ... According to an ... are beginning to account for a significant portion of hernia repairs throughout the United ... the Beverly Hills Hernia Center notes that this trend has not only been expected, ...
(Date:2/12/2016)... ... February 12, 2016 , ... CDRH Enforcement Trends: , Back to the Future , Feb. ... , As Winston Churchill said, “Those who don’t learn from history are doomed to repeat ... when they come knocking this year. But that takes time. , Take a close ...
(Date:2/12/2016)... ... 12, 2016 , ... T.E.N., a technology and information security ... Southeast Awards 2016. Finalists and winners of the ISE® Awards for both Executive ... Awards Gala on March 15, 2016 at the Westin Peachtree Plaza, Atlanta. ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a locally ... a charity drive that will raise funds earmarked to purchase computers and software for ... School. , “My school is in a low-income area and has more than 60 ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... - Cardiac Marker Diagnostic ... and Cancer Therapy. - European Point of Care ... - Key Diagnostic Testing Markets. - Molecular ... Genetic Testing. - Molecular Diagnostics in Infectious Disease ... Diagnostic Products World Markets. - Point of Care ...
(Date:2/11/2016)... 2016 PRO-DEX, INC. (NasdaqCM: PDEX) today announced financial ... 2015. The Company also filed its Quarterly Report on Form ... the Securities and Exchange Commission today. --> ... --> --> Net sales for ... or 95%, to $5.4 million from $2.8 million for the ...
(Date:2/11/2016)... OAKLAND, Calif. , Feb. 11, 2016  Walgreens ... stores across 39 states and Washington, D.C. ... in a move that was commended by shareholder advocacy organization ... President at As You Sow. "Many people hold on to ... options, which can have tragic consequences." --> ...
Breaking Medicine Technology: