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Exercise may play role in reducing inflammation in damaged skin tissue
Date:11/28/2007

In recent years, researchers at the University of Illinois have uncovered a host of reasons for people to remain physically active as they age, ranging from better brain function to improved immune responses.

Now a new U. of I. study points to yet another benefit: a link between moderate exercise and decreased inflammation of damaged skin tissue.

The key point of the study is that moderate exercise sped up how fast wounds heal in old mice, said researcher K. Todd Keylock, who noted that the improved healing response may be the result of an exercise-induced anti-inflammatory response in the wound.

Keylock, now a professor of kinesiology at Bowling Green State University, conducted the research as a doctoral student while working with Jeffrey A. Woods, a U. of I. professor of kinesiology and integrative immunology and behavior. The results appear in the current online edition of the American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. In addition to Keylock and Woods, co-authors are Victoria Vieira, a predoctoral fellow in kinesiology and community health and in nutritional sciences; Matthew Wallig, a professor of veterinary pathobiology; Luisa A. DiPietro, a professor of periodontics and director of the Center for Wound Healing and Tissue Regeneration at the U. of I. at Chicago, and Megan Schrementi, a postdoctoral student in periodontics, U. of I. at Chicago.

While previous research conducted at Ohio State University demonstrated a correlation between wound healing response time and moderate exercise, that research did not reveal a physiological cause for the reaction.

Thats the key part that our study adds that the acceleration and healing were associated with decreased levels of inflammation, Keylock said.

One of the proposed mechanisms whereby aging adds to delayed healing is that the aged have hyper-inflammatory response to wounding, Woods said. The thought is that the exa
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Contact: Melissa Mitchell
melissa@uiuc.edu
217-333-5491
University of Illinois at Urbana-Champaign
Source:Eurekalert

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