Navigation Links
Exercise may lead to faster prostate tumor growth
Date:4/13/2008

DURHAM, N.C. -- Prostate tumors grew more quickly in mice who exercised than in those who did not, leading to speculation that exercise may increase blood flow to tumors, according to a new study by researchers in the Duke Comprehensive Cancer Center (DCCC) and the Duke Prostate Center.

Our study showed that exercise led to significantly greater tumor growth than a more sedentary lifestyle did, in this mouse model, said Lee Jones, Ph.D., a researcher in the DCCC and senior investigator on this study. Our thought is that we may, in the future, be able to use this finding to design better drug delivery models to more effectively treat prostate cancer patients, and those with other types of cancer as well.

The findings were presented in a poster session at the American Association for Cancer Research annual meeting on April 13 in San Diego, Calif. The study was funded by the United States Department of Defense, the Prostate Cancer Foundation and the American Urological Association Foundation, Rising Star in Urology Award, given to Stephen Freedland, one of the studys investigators.

The researchers implanted prostate tumors subcutaneously in the flanks of 50 mice and then put half of the mice in cages with exercise wheels and half in cages with no wheels. All mice were fed the same diet. On average, the exercising mice ran more than half a mile each day.

We found that among the mice that had the opportunity to voluntarily exercise, tumors grew approximately twice as fast as they did among the mice that did not have the opportunity to exercise, Jones said.

Researchers and clinicians know that a challenge in delivering chemotherapy and radiation to tumors can be their poor blood flow, so these findings may hint at a way in which to improve blood flow to tumors, perhaps then allowing for better distribution of medicine, he said.

Were wondering, can we combine exercise with treatments such as chemotherapy, hormone therapy or radiation, to maximize the results we achieve in prostate cancer patients, Jones said. That question will be the subject of subsequent studies.

The researchers are currently conducting a validation study, in mice, in which tumors are injected directly into the prostate, thereby better simulating human prostate cancer, Jones said.

Down the line, we will test this hypothesis in humans undergoing medical treatment for prostate cancer, he said.

The researchers want to caution men against interpreting these findings as an endorsement for not exercising for fear of getting or exacerbating cancer.

These mice were not receiving treatment and we were allowing aggressive tumors to grow unchecked for the sake of the experiment, said study investigator Freedland, a urologist at Duke. Patients would not find themselves in the same situation.

Concerns should also be overridden by the well-established benefits of exercise, including its positive effects on cardiovascular health, Type II diabetes, obesity, and many other chronic conditions, he said.

This study gives us insight into which cellular pathways are affected by exercise, and starts to give us clues about how to harness the beneficial effects, said Michael Potter, a medical student at Duke and lead investigator on the study. Ultimately, we hope that this knowledge will help us use exercise to both deliver medicines more effectively and protect the body from the harmful side effects of treatment, as we already know it can.

This is one of the first studies to look at the physiological effects of exercise on the tumor itself, rather than examining the quality-of-life or symptom-control effects of exercise in cancer patients, Jones said.

The findings were a bit surprising, but provide a very important and exciting foundation upon which to build, he said.


'/>"/>

Contact: Lauren Shaftel Williams
lauren.shaftel@duke.edu
919-684-4966
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Aerobic Exercise Keeps You Young
2. Doctors and Nurses Wellness Checklist: Healthy Diet, Exercise, Dietary Supplements
3. A Month of Exercise Helps Ease Heart Failure
4. Exercise During Pregnancy Has Baby Benefits, Too
5. The Magnificence of Exercise: Choose Movement Over Medication
6. New Ten-Minute Foot Exercisers Beautify Feet for Spring and Summer Sandal Season
7. Neighborhood Influences Exercise Levels
8. YogaPro Celebrates Mothers Day with a Photo Contest to Win YogaToes(R) Foot Care Exercisers to Soothe and Beautify Moms Feet
9. Neighborhoods play key role in how much people exercise, study says
10. Overweight, Obese Women Improve Quality of Life With 10 to 30 Minutes of Exercise
11. Minimal Exercise Benefits Overweight Postmenopausal Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Milford, NJ (PRWEB) , ... October 13, 2017 , ... ... weekend at scenic Alexandria Park in Milford, NJ. This free event, sponsored by ... and physical activity. The fun run is geared towards children of all ages; ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of ... Philippines. “The Journey: From the Mountains to the Mission Field” is the creation of ... taught all ages and currently teaches a class of ladies at her church, which ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized ... have expanded their existing home health joint venture through an agreement, effective October ... a joint venture home health company with Asante, delivering clinically integrated care, for ...
(Date:10/12/2017)... ... 12, 2017 , ... Leading pediatric oncology experts at Children’s National Health ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired ... Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Sept. 28, 2017 Cohen Veterans Bioscience and ... use of wearable and home sensors for real-time monitoring ... Signal Foundation, a nonprofit organization focused on disruptive health ... an affordable analytical system to record and integrate behavioral, ... ...
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest ... Senators Bill Cassidy (R-LA) and Lindsey ... notes that the medical device industry is in an ... device tax, the 2.3% excise tax on medical device ... they also want covered patients, increased visits and hospital ...
Breaking Medicine Technology: