Navigation Links
Exercise can produce healthy chatter between bone, fat and pancreatic cells
Date:9/19/2011

AUGUSTA, Ga. Cells in bone, fat and the pancreas appear to be talking to each other and one thing they likely are saying is, "Get moving."

A small study of obese children enrolled in after-school exercise programs showed 12 weeks of vigorous exercise resulted in stronger bones, improved insulin sensitivity (reduced diabetes risk) and less of the most-deadly belly, or visceral, fat, Georgia Health Sciences University researchers report.

It also indicated that blood levels of the hormone osteocalcin, made by bone-producing osteoblasts, might be a good indicator of how things are going in all three areas, said Dr. Norman Pollock, bone biologist at GHSU's Georgia Prevention Institute.

Pollock's finding is some of the earliest human evidence of this crosstalk among the divergent cell types. Dr. Gerard Karsenty, Chairman of Genetics and Development at Columbia University Medical Center, provided the first evidence of their conversation in animals. In those studies, animals receiving osteocalcin experienced improved insulin sensitivity, less belly fat and denser bones. Osteocalcin levels have primarily been associated with bone growth.

The work earned Pollock a 2011 American Society for Bone and Mineral Research Young Investigator Award. He is presenting the finding during the society's annual September meeting in San Diego.

There have been pieces of evidence of this communication in humans: people with diabetes get a lot of bone fractures; those with more visceral fat are at risk for diabetes; and bone cells have insulin receptors. Ask Pollock why a bone cell would have an insulin receptor and he says it's a question that many are trying to answer with studies such as this one.

"The idea is that bones can possibly sense environmental stimuli such as being physically active or sedentary and dictate energy regulation accordingly," he said. The reality is bones get bigger and stronger with exercise and they appear to be sharing the good news. "When osteocalcin is released in your blood, that hormone is talking back to the adipocytes, the cells that store fat, and the pancreatic cells that release insulin to improve energy metabolism." Bone researchers like Pollock have previously believed bones were just listening.

His study looked at children who were inactive as well as those who exercised 20 or 40 minutes daily. Osteocalcin levels were measured at the start and finish of the 12-week period in addition to standard assessments such as a glucose tolerance test for insulin sensitivity. They found a consistent dose-response so that the children who exercised the most experienced the most bone formation, improved insulin sensitivity and reduced visceral and total body fat.

Pollock notes that bone and fat cells do have a common ancestry: they are both derived from mesenchymal stem cells. "It's possible that children's early lifestyle habits and experiences may induce alterations in body composition and predispose them to a lifetime of obesity," he said. "As parents, we must ensure that our children balance out their screen time with enjoyable physical activity."


'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Related medicine news :

1. Aerobic exercise may reduce the risk of dementia, Mayo Clinic researchers say
2. Bilingual Homes Help Babies Exercise Their Brain: Study
3. Cant Find Time to Exercise? Schedule It, Experts Say
4. Greater Exercise Intensity May Add Years to Life
5. Billie Jean King Says Exercise Your Best Shot Against Arthritis
6. Calling nurses to exercise as role models for their patients
7. Exercise can substitute effectively as second medication for people with depression
8. Metformin and exercise combination less effective for glucose control
9. Study finds 15 minutes of moderate daily exercise lengthens life
10. Want to keep your exercise resolutions? New research offers pointers
11. A Little Exercise Goes a Long Way to Cut Disease, Death Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Exercise can produce healthy chatter between bone, fat and pancreatic cells
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... While it’s ... poses a problem. Fortunately, an inventor from Austin, Texas, has identified a solution. , ... medication in darkness or restricted lighting. As such, it eliminates the need to turn ...
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation ... and home sensors for real-time monitoring of patients with ... nonprofit organization focused on disruptive health solutions for rare ... system to record and integrate behavioral, cognitive, physiological and ... ...
(Date:9/27/2017)... Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... its MyDario product is expected to appear on The Dr. Oz Show ... Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked off ... The segment features ...
Breaking Medicine Technology: