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Exercise benefits found for pregnancies with high blood pressure
Date:11/16/2012

afety concerns that need to be evaluated clinically and exercise continues to be discouraged in pregnancies complicated by high blood pressure.

Working in accordance with National Institutes of Health guidelines for animal use, Gilbert's team induced hypertension in pregnant rats by restricting blood flow to the rat placentas and monitored gestation after six weeks of exercise on activity wheels. Animals in test and control groups ran approximately 30 kilometers per week before pregnancy and approximately 4.5 kilometers per week during pregnancy.

Wheel running before and during pregnancy reduced high blood pressure. It also improved circulating concentrations of vascular endothelial growth factor and restored the balance between that factor and soluble fms-like tyrosine kinase 1, which restricts blood vessel growth and function. The study suggests that exercise lowers high blood pressure by maintaining the balance of these two factors that promote proper blood vessel growth and function.

Exercise also improved endothelial cell function and reduced oxidative stress in the hypertensive rat. Fetal weight was not compromised by exercise and there were no obvious signs of fetal stress in rats with hypertension that exercised, Gilbert said.


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Contact: Matt Cooper
mattc@uoregon.edu
541-346-8875
University of Oregon
Source:Eurekalert

Page: 1 2

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