Navigation Links
Exercise benefits found for pregnancies with high blood pressure
Date:11/16/2012

EUGENE, Ore. (Nov. 16, 2012) Contrary to popular thought, regular exercise before and during pregnancy could have beneficial effects for women that develop high blood pressure during gestation, human physiology professor Jeff Gilbert said, summarizing a new study by his research team that appears in the December issue of Hypertension, a journal of the American Heart Association.

Gilbert's team observed that placental ischemia-induced hypertension in rats was alleviated by exercise and was accompanied by a restoration of several circulating factors that have recently been shown to be important in causing the high blood pressure associated with preeclampsia.

Hypertensive disorders of pregnancy, such as preeclampsia, are the most common dangerous pregnancy complications, occurring in 5 percent to 8 percent of pregnancies. Globally, preeclampsia and other hypertensive disorders of pregnancy cause 76,000 maternal and 500,000 infant deaths each year, conservatively, according to the Preeclampsia Foundation.

"The data from our study raise the possibility that exercise regimens if started before pregnancy and maintained through most of gestation may be an important way for women to mitigate the risk of preeclampsia," Gilbert said. "There are certainly questions that remain, such as when and how much exercise is required and whether exercise training must begin before pregnancy for these beneficial effects to occur. Moreover, further studies are needed to determine if it can safely be used as a therapeutic modality for hypertension caused by insufficient blood flow in the placenta.

"But these results are certainly encouraging," he added.

Previous clinical and epidemiological studies have long suggested that regular exercise before and during pregnancy reduced risk of preeclampsia but definitive mechanistic studies on the topic had been lacking until recently. Even though these findings are exciting, there are still safety concerns that need to be evaluated clinically and exercise continues to be discouraged in pregnancies complicated by high blood pressure.

Working in accordance with National Institutes of Health guidelines for animal use, Gilbert's team induced hypertension in pregnant rats by restricting blood flow to the rat placentas and monitored gestation after six weeks of exercise on activity wheels. Animals in test and control groups ran approximately 30 kilometers per week before pregnancy and approximately 4.5 kilometers per week during pregnancy.

Wheel running before and during pregnancy reduced high blood pressure. It also improved circulating concentrations of vascular endothelial growth factor and restored the balance between that factor and soluble fms-like tyrosine kinase 1, which restricts blood vessel growth and function. The study suggests that exercise lowers high blood pressure by maintaining the balance of these two factors that promote proper blood vessel growth and function.

Exercise also improved endothelial cell function and reduced oxidative stress in the hypertensive rat. Fetal weight was not compromised by exercise and there were no obvious signs of fetal stress in rats with hypertension that exercised, Gilbert said.


'/>"/>

Contact: Matt Cooper
mattc@uoregon.edu
541-346-8875
University of Oregon
Source:Eurekalert

Related medicine news :

1. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
2. Exercise and attitude may be thermostat for hot flashes
3. Women Less Apt Than Men to Get Recommended Daily Exercise
4. Exercise improves quality of life during breast cancer treatment
5. Swallowing exercises linked with short-term improvement among patients with head and neck cancer
6. Swallowing exercises can help patients with head and neck cancer
7. Exercise May Help Patients With High Blood Pressure Live Longer
8. Exercise helps smokers to quit smoking, to remain smoke-free and to reduce the risk of death
9. A comparison of 2 home exercises to treat vertigo
10. Guidelines say diet, exercise, weight control improve odds after cancer diagnosis
11. Exercise Twice a Day Vital for Your Dogs Health, Expert Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... The Golseth Agency, a Texas based insurance management ... spearheading a regional charity campaign organized to provide support to Christina Upchurch and her ... year, Christina and her children returned from out of town to find her husband ...
(Date:8/18/2017)... ... August 18, 2017 , ... Alcovit, a lime-flavored beverage that ... its marketing efforts with its product now available through Jet.com. , After 25 ... The effervescent powdered drink is designed to quickly detox the body thereby avoiding alcohol-induced ...
(Date:8/18/2017)... ... ... “Dangerous Inheritance”: a mystery about saving the family farm. “Dangerous Inheritance” is the ... was raised on a farm. As Diane wrote this story, she used fond ... mantra of ‘neighbors helping neighbors’ have always been a large part of her farming ...
(Date:8/18/2017)... ... August 18, 2017 , ... Rollon Skin ... anti-aging skincare solutions, recently announced the launch of two new skincare products, ... yet effective alternative to expensive plastic surgery or in-patient cosmetic dermatological procedures. , ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... Coatesville Veterans Affairs Medical Center. “Case #10-5411 Veterans Administration” is the creation ... domestic abuse. In June 1990, Carol Mulhem started work at the Coatesville ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)... -- 7D Surgical, developer of ground breaking surgical navigation technologies, ... System to support its strategic sales plan in ... Virginia.  7D Surgical has entered into an exclusive sales representative ... facilities within those markets. ... Spartan Medical Purchases 7D ...
(Date:7/27/2017)... 2017  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) ... 30, 2017.  The Company reported second quarter net sales ... prior year period, and an increase of 2.1% on ... of contribution from the LDR Holding Corporation acquisition, second ... of 2016, or 0.3% on a constant currency basis. ...
(Date:7/26/2017)... Aesthetics, a leading medical aesthetic clinic in Singapore ... skin conditions from the inside. The natural process of ... skin becomes more transparent due to the thinning of the epidermis. Over ... the sun contributes to aging skin, causing age spots and other ... ...
Breaking Medicine Technology: