Navigation Links
Exenatide (Byetta) has rapid, powerful anti-inflammatory effect, UB study shows
Date:11/2/2011

BUFFALO, N.Y. -- Exenatide, a drug commonly prescribed to help patients with type 2 diabetes improve blood sugar control, also has a powerful and rapid anti-inflammatory effect, a University at Buffalo study has shown.

The study of the drug, marketed under the trade name Byetta, was published recently in the Journal of Clinical Endocrinology and Metabolism.

"Our most important finding was this rapid, anti-inflammatory effect, which may lead to the inhibition of atherosclerosis, the major cause of heart attacks, strokes and gangrene in diabetics," says Paresh Dandona, MD, UB Distinguished Professor in the Department of Medicine, UB School of Medicine and Biomedical Sciences, and senior author.

It was especially noteworthy that this anti-inflammatory effect occurred independently of weight loss over the 12-week study period, he adds.

"The fact that the drug caused this dramatic and comprehensive anti-inflammatory effect independent of weight loss shows that it is a primary action of the drug and is not dependent upon weight loss," says Ajay Chaudhuri, MD, associate professor of medicine at UB and lead author.

He explains that, since obesity is an inflammatory state and adipose tissue contributes to inflammation, weight loss on its own can lead to an anti-inflammatory effect.

"Even more importantly, a short-lived anti-inflammatory effect was observed within two hours following a single injection of 5 micrograms of the drug," Chaudhuri continues. "This coincides with the peak concentration of the drug after the injection. Such a rapid and dramatic effect is rare."

"Apart from corticosteroids, which are known anti-inflammatory drugs, and insulin, no other drug demonstrates such a powerful and rapid anti-inflammatory effect," adds Dandona.

As a result, he and his colleagues at UB plan to study how exenatide might be used in acute inflammatory settings in the intensive care unit or following heart attacks and strokes, where a rapid anti-inflammatory effect is required and such drugs may be of potential use.

In addition to the anti-inflammatory effect, participants also exhibited a drop in the measurement of average blood sugar levels over three months, called hemoglobin A1C, from 8.6 percent to 7.4 percent.

The study involved 24 obese type 2 diabetics who were already on insulin to control their glucose levels.

The current study was undertaken based on previous observations published in 2007 by the UB researchers that exenatide indicated an anti-inflammatory effect, reducing plasma C-reactive protein levels, triglycerides and systolic blood pressure.


'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert

Related medicine news :

1. JAK inhibitor provides rapid, durable relief for myelofibrosis patients
2. Improved device provides more rapid, comprehensive analysis of circulating tumor cells
3. MRIs could become powerful tools for monitoring cholesteral therapy
4. Unconventional hunt for new cancer targets leads to a powerful drug candidate for leukemia
5. UBC researchers create more powerful lab-on-a-chip for genetic analysis
6. New Canadian blood pressure education program a powerful tool in fight to reduce stroke
7. Dietary inorganic nitrate may reduce heart dysfunction caused by powerful anti-cancer drug
8. Powerful Women as Likely to Cheat as Men, Study Finds
9. Research Warns of Overuse of Powerful Class of Antibiotics
10. New method powerfully boosts efficiency of RNA interference (RNAi) in shutting down genes
11. Scripps Research scientists develop powerful new methodology for stabilizing proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 2016 , ... EB Medicine presented its first-ever “Issue of ... in Ponte Vedra Beach, FL. The awards honor the outstanding work of leading ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the efforts ...
(Date:6/24/2016)... ... 2016 , ... National recruitment firm Slone Partners is pleased to ... genomics experience, as Vice President of North American Capital Sales at HTG Molecular ... the sales team in the commercialization of the HTG EdgeSeq system and associated reagents ...
(Date:6/24/2016)... ... ... Finally, a bruise cream that really works. Originally designed to reduce ... post-surgical treatment plans of a variety of other procedures including, but not limited to, ... bruising and causes a rapid resolution of bruising and inflammatory changes compared to no ...
(Date:6/24/2016)... ... 24, 2016 , ... SpiritQuest Sedona Retreats, located in Arizona has re-located to ... vortex sites: Cathedral Rock, Airport Mesa, and Boynton Canyon. The new retreat center ... as well as the Sedona Rouge, both popular accommodations for SpiritQuest clients. The ...
(Date:6/23/2016)... ... 23, 2016 , ... vcfo, a consulting firm that provides ... announce the promotion of Mike Mackey to Regional Vice President of Southeast Texas. ... responsible for managing client projects and overseeing vcfo financial consultants in the Houston ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 According to ... Type (Standard Pen Needles, Safety Pen Needles), Needle Length ... Growth Hormone), Mode of Purchase (Retail, Non-Retail) - Trends ... report studies the market for the forecast period of ... USD 2.81 Billion by 2021 from USD 1.65 Billion ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
Breaking Medicine Technology: