BUFFALO, N.Y. -- Exenatide, a drug commonly prescribed to help patients with type 2 diabetes improve blood sugar control, also has a powerful and rapid anti-inflammatory effect, a University at Buffalo study has shown.
The study of the drug, marketed under the trade name Byetta, was published recently in the Journal of Clinical Endocrinology and Metabolism.
"Our most important finding was this rapid, anti-inflammatory effect, which may lead to the inhibition of atherosclerosis, the major cause of heart attacks, strokes and gangrene in diabetics," says Paresh Dandona, MD, UB Distinguished Professor in the Department of Medicine, UB School of Medicine and Biomedical Sciences, and senior author.
It was especially noteworthy that this anti-inflammatory effect occurred independently of weight loss over the 12-week study period, he adds.
"The fact that the drug caused this dramatic and comprehensive anti-inflammatory effect independent of weight loss shows that it is a primary action of the drug and is not dependent upon weight loss," says Ajay Chaudhuri, MD, associate professor of medicine at UB and lead author.
He explains that, since obesity is an inflammatory state and adipose tissue contributes to inflammation, weight loss on its own can lead to an anti-inflammatory effect.
"Even more importantly, a short-lived anti-inflammatory effect was observed within two hours following a single injection of 5 micrograms of the drug," Chaudhuri continues. "This coincides with the peak concentration of the drug after the injection. Such a rapid and dramatic effect is rare."
"Apart from corticosteroids, which are known anti-inflammatory drugs, and insulin, no other drug demonstrates such a powerful and rapid anti-inflammatory effect," adds Dandona.
As a result, he and his colleagues at UB plan to study how exenatide might be used in acute inflammatory settings in the intensive care unit or following heart attack
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