Navigation Links
Exciting discovery could 'stop cancer from killing people'
Date:12/14/2008

Metastasis is the ability of cancer cells to spread from a primary site, to form tumours at distant sites. It is a complex process in which cell motility and invasion play a fundamental role. Essential to our understanding of how metastasis develops is identification of the molecules, and characterisation of the mechanisms that regulate cell motility. Hitherto, these mechanisms have been poorly understood. Now, a team of researchers lead by Professor Marco Falasca at Barts and The London School of Medicine and Dentistry has shown not only that the enzyme phospholipase Cγ1 (PLCγ1) plays a crucial role in metastasis formation, but that down regulation of PLCγ1 expression is able to revert metastasis progression.

The team investigated the role of PLCγ1 in cell invasion and metastasis using different approaches to modulate its expression in highly invasive cancer cell lines. Their results showed that PLCγ1 is required for breast cancer cell invasion and activation of the protein Rac1. They revealed a functional link between PLCγ1 and Rac1 that provides insight into processes regulating cell invasion.

Professor Falasca explained: "Consistent with these data we detected an increase in PLC1 expression in metastases compared to primary tumours in breast cancer patients. Therefore PLCγ1 is critical for metastasis formation, and development and inhibition of this enzyme has a therapeutic potential in the treatment of metastasis dissemination."

"This is an exciting discovery. He has shown that turning off this molecule prevents metastasis. The simple fact is that if you stop metastasis, you stop cancer from killing people. We now need to focus on developing drugs that can block PLCγ1."


'/>"/>

Contact: Alex Fernandes
a.fernandes@qmul.ac.uk
020-788-27910
Queen Mary, University of London
Source:Eurekalert

Page: 1

Related medicine news :

1. Nosespray vaccine using aloe vera has exciting potential, researcher says
2. Exciting New Plan from John Edwards on AIDS; Plan is Bold and Achievable, say New Hampshire Activists
3. 3 Tesla + 70 cm + Tim = The Most Exciting Equation in MRI
4. Leicester scientist announces unexpected and exciting advance in study of cancer type
5. WRAIR investigators pioneering work on an exciting new class of antimalarial compounds
6. Cholera study provides exciting new way of looking at infectious disease
7. Reflex Stock Launches Exciting New Editorial Image Collections to the Worldwide Publishing Industry
8. New NAMC Member Service! Complimentary Webinars for NAMC Members - On Topics You Need to Know! Sign Up Today for This New and Exciting Educational Program!
9. Discovery of sugar sensor in intestine could benefit diabetes
10. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
11. Stem cell research produces a key discovery for Fragile X Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... UC Irvine immunologists reveals new information about how our ... that determines how the body,s ability to fight infection ... Immunology , neurology professor Dr. Michael Demetriou, postdoctoral scholar ... a critical mechanism underlying how T cells are created, ... cell is a type of blood cell called a ...
(Date:9/30/2014)... September 30, 2014 EverStryke , the ... introduction to SurvivalLife.com along with a free book and class ... of Shane Michaels, prompting an investigative review. , “Joe ... in the survival and preparation niche, and this product is ... great classes and survival products that Joe offers on his ...
(Date:9/30/2014)... September 30, 2014 VisitandCare.com ... Turkey has gone up more than 79 percent in ... tourism company also reported total revenue tripled for its ... The company’s professional strategy has allowed them to partner ... designed for patient comfort and privacy — with state-of-the-art ...
(Date:9/30/2014)... Regenerative Medicine Solutions (RMS) is set ... Nashville, Tennessee. RMS welcomes the launch of an entirely ... of a new treatment center for the Lung Institute. ... Institute to Nashville, the hope is to bring awareness ... diagnosed and undiagnosed. With Nashville being a hub for ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Bifidobacteria, the ... with age, poor diet, and stress, so a high ... Each capsule of Ultimate Flora™ Men’s Complete ... cultures from 7 Bifidobacteria strains to support a healthy ... to build up, and 32 billion cultures from 7 ...
Breaking Medicine News(10 mins):Health News:UCI study uncovers important process for immune system development 2Health News:EverStryke: Review Exposes Joe Marshall’s Permanent Match Survival Product 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 3Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 4Health News:Regenerative Medicine Solutions Expanding 2Health News:ReNew Life Introduces Ultimate Flora™ Men’s Complete Probiotic 90 Billion—Comprehensive Probiotic Support Just for Men 2
... are reminded to protect their eyes and skin ... dangerous UV rays on and off the field, PINELLAS PARK, ... eagerly awaited time to enjoy outdoor sports and activities.,However, many forget ... practice outdoor sports -- particularly in the summer,-- are conscious of ...
... July 29 On October 30, millions of breast,cancer ... glasses in a "Toast to the Cure.", This ... by breast cancer to memorialize those friends and family ... the stories of,survivors, commending cause advocates, thanking supporters, and ...
... Despite Experiencing Leg Pain and ... Discomfort, ... legs -- force many embarrassed sufferers to cover up, even on,the hottest ... develop into serious health problems. According,to a new survey, many who suffer ...
... found that cerebral malaria is related to long-term cognitive impairment in ... current issue of the journal Pediatrics . , ... is a leading cause of death for children in sub-Saharan Africa. ... is one of the deadliest forms of malaria. It only takes ...
... ANNAPOLIS, Md., July 29 RiskWatch, Inc. announced ... RWSURVEY,available http://www.rwsurvey.com ., The web-based software allows ... surveys online and includes compliance surveys for:, ... PCI HIPAA Compliance BSA-AML ISO 27001 ...
... July 29 American Imaging Management (AIM), an,operating ... and leading imaging,benefit management and technology company with ... that it has reached an,agreement to provide diagnostic ... of Vermont (BCBSVT)., "As a company that ...
Cached Medicine News:Health News:Transitions Optical Offers Tips on How to Protect Eyes for Outdoor Sports Fans 2Health News:Video: A 'Toast to the Cure' Set for October 30 Breast Cancer Survivors 'Raise Your Glasses' 2Health News:Survey Shows People With Varicose Veins Unaware of Health Risks; Most Never Consider Treatment 2Health News:Survey Shows People With Varicose Veins Unaware of Health Risks; Most Never Consider Treatment 3Health News:Survey Shows People With Varicose Veins Unaware of Health Risks; Most Never Consider Treatment 4Health News:U of M researchers find cerebral malaria may be a major cause of brain injury in African children 2Health News:New Web-Based Compliance Program Released by RiskWatch 2Health News:American Imaging Management Partners with Blue Cross and Blue Shield of Vermont 2
(Date:9/30/2014)... , Sept. 30, 2014 A study ... (OCT), offered a new look at the composition of ... how physicians understand and treat the disease, a leading ... at Baptist Health Lexington between September 2010 and May ... the Journal of the American College of Cardiology ...
(Date:9/30/2014)... Calif. , Sept. 30, 2014  HealthLoop® released ... integrates with HealthKit in iOS 8 and allows people ... doctors. The app harnesses native iOS technologies to enhance ... maintain a robust connection with their doctors between visits. ... devices and the data they collect is exciting," says ...
(Date:9/30/2014)... 30, 2014  Georgia-Pacific Professional is a leading ... for a wide range of away from home ... lines in healthcare, including hospitals, long-term care facilities, ... introducing its healthcare products and solutions to the ... importance of infection control in the dental office," ...
Breaking Medicine Technology:New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient 2HealthLoop Integrates with Apple's HealthKit Enabling Patients to Share Health Data with Their Doctors Right from their iPhone 2Georgia-Pacific Professional Brings Its Success in Medical Solutions to the Dental Community 2Georgia-Pacific Professional Brings Its Success in Medical Solutions to the Dental Community 3
... May 19 ImaginAb, Inc. and the GSK Clinical Imaging Centre ... agreements around a clinical therapeutic antibody asset currently under development by GSK ... , , ... CIC," said Dr. Christian Behrenbruch , CEO of ImaginAb. "Not only ...
... 19 ... only conference dedicated to addressing the challenges facing the ... Medical Product Outsourcing magazine, invites OEM professionals and ... agenda and extraordinary lineup of speakers. Detailed registration and ...
Cached Medicine Technology:ImaginAb, Inc. and GlaxoSmithKline Establish Collaboration 2Medical Product Outsourcing Magazine Announces the First Annual CardioTec Conference 2Medical Product Outsourcing Magazine Announces the First Annual CardioTec Conference 3
... is the first hernia repair material ... operative contamination of the material. This ... preservative agents, silver carbonate and chlorhexidine ... colonization on the patch for up ...
... in 1958, Bard mesh has become the ... compared. Bard mesh was used by Dr. ... "tension-free" hernia repair many years ago. Lichtenstein ... ideal" substance for permanent reinforcement of hernia ...
... PerFix plug technique, recommended for the ... indirect and direct inguinal hernias, provides ... technique, requiring less overall dissection and ... repair technique. The result is increased ...
... is a compact, highly portable, single wavelength ... integrated StarPulse feature enables the treatment of ... leg and face, and pigmented surface lesions, ... used as a continuous wave laser for ...
Medicine Products: