Navigation Links
Excessive alcohol consumption may lead to increased cancer risk
Date:4/21/2010

WASHINGTON, D.C. Researchers have detected a link between alcohol consumption, cancer and aging that starts at the cellular level with telomere shortening.

Results of this cross-sectional study were presented at the American Association for Cancer Research 101st Annual Meeting 2010, held here, April 17-21, at the Walter E. Washington Convention Center.

Telomeres are found at the region of DNA sequences at the end of a chromosome, and are important for the genetic stability of cells. As people age, telomere length shortens progressively.

Excessive use of alcohol has been linked to oxidative stress and inflammation, two mechanisms that accelerate telomere shortening. Since telomere shortening is thought to increase cancer risk, the researchers speculated that those with shorter telomeres due to heavy alcohol consumption would have an increased risk of cancer.

"Heavy alcohol users tend to look haggard, and it is commonly thought heavy drinking leads to premature aging and earlier onset of diseases of aging. In particular, heavy alcohol drinking has been associated with cancer at multiple sites," said lead researcher Andrea Baccarelli, M.D., Ph.D.

"All the cells in our body have a biological clock in telomeres," noted Baccarelli, who is head of the Center of Molecular and Genetic Epidemiology, Ca' Granda Hospital Foundation, University of Milan, Italy.

Using real-time polymerase chain reaction, the researchers measured serum DNA among 59 participants who abused alcohol (22 percent consumed four or more alcoholic drinks per day) and 197 participants with variable alcohol consumption habits (4 percent consumed four or more alcoholic drinks per day).

The two groups were similar in age and other factors that might affect telomere length, such as diet, physical exercise, work-related stress and environmental exposures.

Results showed that telomere length was dramatically shortened in those who consumed heavy amounts of alcohol; telomere length was nearly half as long as telomere length in the non-abusers (0.41 vs. 0.79 relative units).

Carriers of the variant genotype ADH1B were more likely to be abusers and had shorter telomere length, according to Baccarelli.

"The decrease we found in telomere length is very sharp, and we were surprised to find such a strong effect at the cellular level," Baccarelli said.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Sweating the Interview: Excessive Sweaters Need not Apply?
2. Excessive Weight Gain During Pregnancy Raises Gestational Diabetes Risk
3. Les Consquences De La Pche Excessive Sur l'environnement -- Un Documentaire Sur La Disparition Du Thon Rouge
4. Gene variation makes alcoholism less likely in some survivors of sexual abuse
5. Alcohol consumption may increase breast cancer recurrence risk
6. Attendance at Alcoholics Anonymous meetings may reduce depression symptoms
7. Stress Hormone Could Be Key to Alcoholism
8. Alcohol Affects Babys Pain Regulation
9. Too Much Alcohol Impairs Seniors Thinking
10. Alcohol companies target youths with magazine ads, new study shows
11. Alcohol Countermeasure Systems Penetrates New Markets Through Acquisition of Seres Ethylometre of France
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... , ... May 26, 2016 , ... ... clinical outcomes, hosted members and suppliers for its inaugural Member Conference at the ... their mission of elevating the operational health of America’s healthcare providers. , The ...
(Date:5/26/2016)... ... May 26, 2016 , ... Connor Sports, through ... a partner for the Tamika Catchings Legacy Tour that will commemorate the ... in hardwood basketball surfaces in all forms and levels of the game, Connor Sports ...
(Date:5/26/2016)... ... ... The Woodlands at John Knox Village , Florida’s first Life Plan ... and healing, celebrated its grand opening, today. The Woodlands at John Knox Village is ... Staff. , “This is an incredibly fulfilling time for John Knox Village as we ...
(Date:5/26/2016)... ... ... There are nearly 14.5 million people living with and beyond cancer in the ... 2016, communities around the world will gather to recognize these cancer survivors as part ... is an annual worldwide Celebration of Life that is held on the first Sunday ...
(Date:5/26/2016)... ... 2016 , ... Catalent Pharma Solutions, the leading global provider ... global clinical supply services, today announced two key appointments and the opening of ... strategic growth plans in the Asia Pacific region. , Howard Kim has joined ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... -- FDA 510(k) clearance covers Confocal ... urological and surgical applications Mauna Kea ... the multidisciplinary confocal laser endomicroscopy (CLE) platform, today ... with the 12 th 510(k) clearance from ... new FDA clearance covers Confocal Miniprobes indicated for ...
(Date:5/25/2016)... , May 25, 2016  According to Kalorama Information, ... billion in 2015.  Though these are challenging times ... opportunity for success for companies that remain optimistic ... of new growth prospects medical device companies spend ... and development (R&D) than do companies in other ...
(Date:5/25/2016)... PARIS , May 25, 2016 ... system disorders, announces that an oral presentation entitled "High doses ... the MS-SPI trial" will be given by Professor Ayman ... the 2nd Congress of the European Academy of Neurology (EAN) ... "MS and related disorders 3" will take place on Sunday, ...
Breaking Medicine Technology: