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Excessive Heat Can Harm Medications, Expert Says
Date:8/20/2011

SATURDAY, Aug. 20 (HealthDay News) -- Medications can be harmed by high temperatures, say pharmacists.

Although just a handful of drugs have been tested at temperatures above 86F, all medications could be altered by extreme heat, they warn.

According to Dr. Amy Peak, clinical pharmacist and director of Drug Information Services at Butler University, several medications have been tested at high temperatures. She outlined some of the changes the researchers found:

  • Albuterol inhalers: The container could burst at temperatures above 120F. Moreover, when stored at high temperatures, there may be a decrease in the amount of medication inhaled.
  • Concentrated epinephrine: Cyclical heating could reduce 64 percent of the medication's potency.
  • Diazepam: Concentration of this drug dropped 25 percent when stored at 98.6F.
  • Formoterol (capsules that are placed in inhalers): Following four hours of exposure to 158F heat, the amount released from the capsules was less than half the normal amount.
  • Lorazepam: When stored at 98F, concentration decreased 75 percent.
  • Mometasone (formoterol inhalers): Temperatures above 120F may cause the container to burst.

Peak says several more medications may be susceptible to excessive heat, including:

  • Insulin: Excessive heat could make the insulin less effective. It could also cause the insulin vials to explode.
  • Thyroid hormones: Thyroid hormones could be altered by excessively high temperatures, resulting in inconsistent doses.
  • Any medications in aerosolized canisters could burst when exposed to temperatures above 120F.

Although the United States Pharmacopeia Convention Inc. recommends that medications be protected from excessive heat, only a few drugs are actually tested at temperatures above 86F, Peak pointed out.

Nevertheless, she noted there are
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